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A Randomized Trial to Compare Dolutegravir Plus Boosted Darunavir Versus Recommended Standard of Care Antiretroviral Regimens in People With HIV-1, Whose First-line Non-nucleoside Reverse Transcriptase Inhibitor Therapy Has Failed: Final 96-week Results of the D2EFT Study.

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Title: A Randomized Trial to Compare Dolutegravir Plus Boosted Darunavir Versus Recommended Standard of Care Antiretroviral Regimens in People With HIV-1, Whose First-line Non-nucleoside Reverse Transcriptase Inhibitor Therapy Has Failed: Final 96-week Results of the D2EFT Study.
Authors: Nyein PP; The Kirby Institute, University of New South Wales, Sydney, Australia., Borok M; Department of Internal Medicine, Faculty of Medicine and Health Sciences, University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Eriobu N; International Research Center of Excellence (IRCE), Institute of Human Virology Nigeria, Abuja, Nigeria., Kaplan R; Desmond Tutu Health Foundation, Cape Town, South Africa., Kumarasamy N; Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS) Voluntary Health Services (VHS), Chennai, India., Avihingsanon A; HIV-NAT, Thai Red Cross AIDS and Infectious Disease Research Centre, and Center of Excellence in Tuberculosis, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Losso MH; CICAL, Fundación IBIS, Buenos Aires, Argentina., Azwa I; Infectious Disease Unit, Department of Medicine and Centre of Excellence for Research in Infectious Diseases & AIDS (CERIA), Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia., Karyana M; INA-RESPOND, Jakarta, Indonesia., Dao S; Department of Infectious and Tropical Diseases, Faculty of Medicine and Dentistry, University of Science, Technics and Technologies of Bamako, Mali., Cisse M; Centre de traitement ambulatoire de Donka (Hospital de jour), Université Gamal Abdel Nasser de Conakry, Conakry, Guinea., Andrade Villanueva JF; Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Guadalajara, Mexico., Lupo S; Instituto CAICI (Instituto Centralizado de Asistencia e Investigación Clinica Integral), Rosario, Argentina., Cardoso SW; Fiocruz-Instituto Nacional de Infectologia (INI), Rio de Janeiro, Brazil., Yunihastuti E; Cipto Mangunkusumo Hospital/Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia., Subronto YW; Department of Internal Medicine/Centre of Tropical Medicine Study Program, Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia., Fitriah M; Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, Indonesia., Katu S; Department of Internal Medicine, Faculty of Medicine, Universitas Hasanuddin/Division of Tropical and Infection Disease, Dr. Wahidin Sudirohusodo Hospital, Makassar, South Sulawesi, Indonesia., Brown D; Global Medical Sciences, ViiV Healthcare, Abbotsford, New South Wales, Australia., Papot E; The Kirby Institute, University of New South Wales, Sydney, Australia., Hutchinson J; The Kirby Institute, University of New South Wales, Sydney, Australia., Kelleher A; The Kirby Institute, University of New South Wales, Sydney, Australia., Hanson J; The Kirby Institute, University of New South Wales, Sydney, Australia., Dharan NJ; The Kirby Institute, University of New South Wales, Sydney, Australia., Petoumenos K; The Kirby Institute, University of New South Wales, Sydney, Australia., Matthews GV; The Kirby Institute, University of New South Wales, Sydney, Australia.
Corporate Authors: D2EFT Study Team
Source: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2026 Feb 04; Vol. 81 (6), pp. e568-e580.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III; Clinical Trial, Phase IV; Comparative Study
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Randomized Trial to Compare Dolutegravir Plus Boosted Darunavir Versus Recommended Standard of Care Antiretroviral Regimens in People With HIV-1, Whose First-line Non-nucleoside Reverse Transcriptase Inhibitor Therapy Has Failed: Final 96-week Results of the D2EFT Study.
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