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Self-amplifying NRF2-EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer.

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Title: Self-amplifying NRF2-EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer.
Authors: Antonucci L; Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California, San Diego School of Medicine, La Jolla, CA, USA., Li N; Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Jinan, China., Duran A; Department of Pathology and Laboratory Medicine and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Cobo I; Department of Cellular & Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.; Division of Clinical Immunology & Rheumatology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center, University of Alabama at Birmingham, Birmingham, AL, USA., Nicoletti C; Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Watari K; Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California, San Diego School of Medicine, La Jolla, CA, USA., Nandi SP; Department of Cellular & Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.; Moores Cancer Center, University of California, San Diego School of Medicine, La Jolla, CA, USA., Zhu F; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Zhao Y; CCR Sequencing Facility Bioinformatics Group, Bioinformatics and Computational Science Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Riahi I; Departments of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA., Tsuda M; Department of Molecular and Medical Genetics, School of Medicine Oregon Health and Science University, Portland, OR, USA., Shah VM; Department of Molecular and Medical Genetics, School of Medicine Oregon Health and Science University, Portland, OR, USA.; Brenden-Colson Center for Pancreatic Care, School of Medicine Oregon Health and Science University, Portland, OR, USA., Morgan T; Department of Pathology, School of Medicine Oregon Health and Science University, Portland, OR, USA., Waugh T; Brenden-Colson Center for Pancreatic Care, School of Medicine Oregon Health and Science University, Portland, OR, USA., Caputo L; Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Liu Y; Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California, San Diego School of Medicine, La Jolla, CA, USA., Rundberg Nilsson A; Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California, San Diego School of Medicine, La Jolla, CA, USA., Xian H; Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California, San Diego School of Medicine, La Jolla, CA, USA., Todoric J; Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California, San Diego School of Medicine, La Jolla, CA, USA.; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria., Gu L; Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California, San Diego School of Medicine, La Jolla, CA, USA., Sanchez-Lopez E; Department of Orthopedic Surgery, University of California, San Diego School of Medicine, La Jolla, CA, USA., Eibl G; Department of Surgery, University of California, Los Angeles, Los Angeles, CA, USA., Vucic EA; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA., Krawczyk M; Department of Physiology and Biophysics, Center for Translational Vision Research, School of Medicine, University of California, Irvine, Irvine, CA, USA., Xu Q; Department of Physiology and Biophysics, Center for Translational Vision Research, School of Medicine, University of California, Irvine, Irvine, CA, USA., Lowy AM; Department of Surgery, Division of Surgical Oncology, Moores Cancer Center, University of California, San Diego School of Medicine, La Jolla, CA, USA., Hatzivassiliou G; Genentech, Inc., San Francisco, CA, USA., Roose-Girma M; Genentech, Inc., San Francisco, CA, USA., Skowronska-Krawczyk D; Department of Physiology and Biophysics, Center for Translational Vision Research, School of Medicine, University of California, Irvine, Irvine, CA, USA., Scott DA; Cancer Metabolism Core, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Bar-Sagi D; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA., Tamayo P; Center for Novel Therapeutics and Division of Medical Genetics, Department of Medicine, Moores Cancer Center, University of California, San Diego School of Medicine, La Jolla, CA, USA., Wu Y; CCR Sequencing Facility Bioinformatics Group, Bioinformatics and Computational Science Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Sears RC; Department of Molecular and Medical Genetics, School of Medicine Oregon Health and Science University, Portland, OR, USA.; Brenden-Colson Center for Pancreatic Care, School of Medicine Oregon Health and Science University, Portland, OR, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA., Glass CK; Department of Cellular & Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA., Alexandrov LB; Department of Cellular & Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.; Moores Cancer Center, University of California, San Diego School of Medicine, La Jolla, CA, USA.; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Puri PL; Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Dawson DW; Departments of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA., Hu Y; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Diaz-Meco MT; Department of Pathology and Laboratory Medicine and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Moscat J; Department of Pathology and Laboratory Medicine and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Karin M; Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California, San Diego School of Medicine, La Jolla, CA, USA. karinoffice@health.ucsd.edu.
Source: Nature cancer [Nat Cancer] 2025 Jul; Vol. 6 (7), pp. 1263-1282. Date of Electronic Publication: 2025 Jun 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
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