Imbalanced TGFβ signalling and autophagy drive erythroid priming of hematopoietic stem cells in β-thalassemia.
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| Title: | Imbalanced TGFβ signalling and autophagy drive erythroid priming of hematopoietic stem cells in β-thalassemia. |
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| Authors: | Lidonnici MR; San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy. lidonnici.mariarosa@hsr.it., Chianella G; San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.; University Vita-Salute San Raffaele, Milan, Italy., Mende N; Wellcome-MRC Cambridge Stem Cell Institute, Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Bastos HP; Wellcome-MRC Cambridge Stem Cell Institute, Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Barcella M; San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy., Merelli I; Institute for Biomedical Technologies, National Research Council, Segrate, Italy., Storto M; San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy., Romeo V; San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy., Tiboni F; San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy., Scaramuzza S; San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy., Rossi C; San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy., Raggi L; San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy., Aprile A; San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy., Crippa S; San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy., Iskander D; Department of Immunology & Inflammation, Imperial College London, London, UK., Roberts I; Department of Paediatrics, University of Oxford, Oxford, UK., Karamiditris A; Department of Immunology & Inflammation, Imperial College London, London, UK., Keith J; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Lechauve C; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Weiss MJ; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wilson NK; Wellcome-MRC Cambridge Stem Cell Institute, Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Göttgens B; Wellcome-MRC Cambridge Stem Cell Institute, Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Bernardo ME; San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.; University Vita-Salute San Raffaele, Milan, Italy.; Pediatric Immunohematology, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Haematology and BMT Unit IRCCS San Raffaele Scientific Institute, Milan, Italy., Ciceri F; San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.; University Vita-Salute San Raffaele, Milan, Italy.; Haematology and BMT Unit IRCCS San Raffaele Scientific Institute, Milan, Italy., Aiuti A; San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.; University Vita-Salute San Raffaele, Milan, Italy.; Pediatric Immunohematology, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Haematology and BMT Unit IRCCS San Raffaele Scientific Institute, Milan, Italy., Marktel S; San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.; Haematology and BMT Unit IRCCS San Raffaele Scientific Institute, Milan, Italy., Laurenti E; Wellcome-MRC Cambridge Stem Cell Institute, Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Ferrari G; San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy. ferrari.giuliana@hsr.it.; University Vita-Salute San Raffaele, Milan, Italy. ferrari.giuliana@hsr.it. |
| Source: | Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5639. Date of Electronic Publication: 2025 Jul 01. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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