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Whole genome and transcriptome profiling in advanced pancreatic cancer patients on the COMPASS trial.

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Title: Whole genome and transcriptome profiling in advanced pancreatic cancer patients on the COMPASS trial.
Authors: Knox JJ; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. Jennifer.knox@uhn.ca., Jang GH; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada., Grant RC; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada., Zhang A; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada., Ma L; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Elimova E; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Jang R; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Moore M; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Biagi J; Kingston Health Sciences Centre, Toronto, ON, Canada., Tehfe M; Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada., Ramjeesingh R; Division of Medical oncology, QEII Health Sciences Centre, Halifax, NS, Canada., Tsang ES; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Holter S; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Ramotar S; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Hutchinson S; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Liang SB; Princess Margaret Cancer Biobank (PMCB), University Health Network, Toronto, ON, Canada., Lungu IM; Ontario Institute for Cancer Research Toronto, Toronto, ON, Canada., Moura S; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Wang Y; The Research Institute of the McGill University Health Centre, Montreal, QC, Canada.; The Rosalind & Morris Goodman Cancer Institute, Montreal, QC, Canada., Perera S; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Chan-Seng-Yue M; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada., Monajemzadeh M; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Aung K; Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Prince R; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Romero JM; The Research Institute of the McGill University Health Centre, Montreal, QC, Canada.; The Rosalind & Morris Goodman Cancer Institute, Montreal, QC, Canada., Fuentes-Antras J; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Gonzalez Conchas GA; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Picardo S; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Gonzalez R; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Ghai S; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Joint Department of Medical Imaging, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, ON, Canada., Khalili K; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Joint Department of Medical Imaging, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, ON, Canada., Kyoung Kim T; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Joint Department of Medical Imaging, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, ON, Canada., Ng K; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada., Bartlett J; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Edinburgh Cancer Research Centre, Western General Hospital, Edinburgh, UK., Pugh TJ; Ontario Institute for Cancer Research Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre University Health Network, Toronto, ON, Canada., Kalimuthu SN; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Pathology, University Health Network, Toronto, ON, Canada., Fischer SE; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Pathology, University Health Network, Toronto, ON, Canada., Wilson JM; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada., Dodd A; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Zogopoulos G; The Research Institute of the McGill University Health Centre, Montreal, QC, Canada.; The Rosalind & Morris Goodman Cancer Institute, Montreal, QC, Canada., Grünwald BT; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Urology, University Hospital Essen, Essen, Germany.; West German Cancer Center, Essen, Germany., Notta F; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada., Gallinger S; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada., O'Kane GM; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. grainne.okane@ucd.ie.; St. Vincent's University Hospital and School of Medicine, University College Dublin, Dublin, Ireland. grainne.okane@ucd.ie.
Source: Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5919. Date of Electronic Publication: 2025 Jul 01.
Publication Type: Journal Article; Multicenter Study; Observational Study
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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