HDL-bound S1P affects the subventricular niche and early neuropathological features of Alzheimer's disease.

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Title: HDL-bound S1P affects the subventricular niche and early neuropathological features of Alzheimer's disease.
Authors: Choi BJ; KNU AD Research Institute, Kyungpook National University, Daegu, South Korea.; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea., Hong JY; KNU AD Research Institute, Kyungpook National University, Daegu, South Korea.; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea., Park MH; KNU AD Research Institute, Kyungpook National University, Daegu, South Korea.; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea., Park KH; KNU AD Research Institute, Kyungpook National University, Daegu, South Korea.; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea., Han WH; KNU AD Research Institute, Kyungpook National University, Daegu, South Korea.; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea., Yoon HJ; KNU AD Research Institute, Kyungpook National University, Daegu, South Korea.; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea., Jung HY; KNU AD Research Institute, Kyungpook National University, Daegu, South Korea.; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea., Kim KY; KNU AD Research Institute, Kyungpook National University, Daegu, South Korea.; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea., Lee SA; KNU AD Research Institute, Kyungpook National University, Daegu, South Korea.; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea., Lim EY; KNU AD Research Institute, Kyungpook National University, Daegu, South Korea.; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea., Hur JW; KNU AD Research Institute, Kyungpook National University, Daegu, South Korea.; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea., Song IS; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, Vessel-Organ Interaction Research Center (VOICE), College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, South Korea., Jeon SY; College of Pharmacy, Dankook University, Cheon-an, South Korea., Choi MK; College of Pharmacy, Dankook University, Cheon-an, South Korea., Christoffersen C; Department of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark.; Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3A, Copenhagen, Denmark., Kim HJ; Department of Neurology, College of Medicine, Hanyang University, Seoul, South Korea., Kim SH; Department of Neurology, College of Medicine, Hanyang University, Seoul, South Korea., Schuchman EH; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Bae JS; KNU AD Research Institute, Kyungpook National University, Daegu, South Korea. jsbae@knu.ac.kr.; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea. jsbae@knu.ac.kr., Jin HK; KNU AD Research Institute, Kyungpook National University, Daegu, South Korea. hkjin@knu.ac.kr.; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, South Korea. hkjin@knu.ac.kr.
Source: Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5728. Date of Electronic Publication: 2025 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-60750-0