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Potential role of avibactam in restoring susceptibility in Escherichia coli with two copies of blaKPC-3 and PBP3 mutations.

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Title: Potential role of avibactam in restoring susceptibility in Escherichia coli with two copies of blaKPC-3 and PBP3 mutations.
Authors: Giuliano S; Infectious Diseases Clinic, Azienda Sanitaria Universitaria Friuli Centrale, 33100, Udine, Italy. simone.giuliano@asufc.sanita.fvg.it., Fox V; Multimodal Laboratory Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Ferin S; Department of Medicine (DMED), University of Udine, Udine, Italy., Martini L; Department of Medicine (DMED), University of Udine, Udine, Italy., Angelini J; Department of Medicine (DMED), University of Udine, Udine, Italy.; Clinical Pharmacology Institute, University Hospital Friuli Centrale ASUFC, 33100, Udine, Italy., Bulfoni M; Department of Medicine (DMED), University of Udine, Udine, Italy.; Department of Laboratory Medicine, Azienda Sanitaria Universitaria Friuli Centrale, 33100, Udine, Italy., Krpan B; Department of Medicine (DMED), University of Udine, Udine, Italy.; Department of Laboratory Medicine, Azienda Sanitaria Universitaria Friuli Centrale, 33100, Udine, Italy., Gualandi N; Department of Medicine (DMED), University of Udine, Udine, Italy., Moreal C; Department of Medicine (DMED), University of Udine, Udine, Italy., Perno CF; Multimodal Laboratory Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.; Microbiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Bernaschi P; Microbiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Di Gennaro C; UOC Medicina/PS Ospedale A. Rizzoli, ASL Napoli 2 Nord, Lacco Ameno d'Ischia, Italy., Arcamone C; UOC Medicina/PS Ospedale A. Rizzoli, ASL Napoli 2 Nord, Lacco Ameno d'Ischia, Italy., Turco S; Università degli Studi della Campania Luigi Vanvitelli, Caserta, Italy., Stanziola MC; Dipartimento di Diagnostica di Laboratorio, Patologia Clinica Ospedale A. Rizzoli, ASL NA2 Nord, Lacco Ameno d'Ischia, Italy., Manzi R; Dipartimento di Diagnostica di Laboratorio, Patologia Clinica Ospedale A. Rizzoli, ASL NA2 Nord, Lacco Ameno d'Ischia, Italy., Curcio F; Department of Medicine (DMED), University of Udine, Udine, Italy.; Department of Laboratory Medicine, Azienda Sanitaria Universitaria Friuli Centrale, 33100, Udine, Italy., Pipan C; Department of Medicine (DMED), University of Udine, Udine, Italy.; Public Health Laboratory, Azienda Sanitaria Universitaria Friuli Centrale, 33100, Udine, Italy., Tascini C; Infectious Diseases Clinic, Azienda Sanitaria Universitaria Friuli Centrale, 33100, Udine, Italy.; Department of Medicine (DMED), University of Udine, Udine, Italy.
Source: Scientific reports [Sci Rep] 2025 Jul 01; Vol. 15 (1), pp. 21161. Date of Electronic Publication: 2025 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Potential role of avibactam in restoring susceptibility in Escherichia coli with two copies of bla<subscript>KPC-3</subscript> and PBP3 mutations.
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  Data: <searchLink fieldCode="AU" term="%22Giuliano+S%22">Giuliano S</searchLink>; Infectious Diseases Clinic, Azienda Sanitaria Universitaria Friuli Centrale, 33100, Udine, Italy. simone.giuliano@asufc.sanita.fvg.it.<br /><searchLink fieldCode="AU" term="%22Fox+V%22">Fox V</searchLink>; Multimodal Laboratory Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ferin+S%22">Ferin S</searchLink>; Department of Medicine (DMED), University of Udine, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Martini+L%22">Martini L</searchLink>; Department of Medicine (DMED), University of Udine, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Angelini+J%22">Angelini J</searchLink>; Department of Medicine (DMED), University of Udine, Udine, Italy.; Clinical Pharmacology Institute, University Hospital Friuli Centrale ASUFC, 33100, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Bulfoni+M%22">Bulfoni M</searchLink>; Department of Medicine (DMED), University of Udine, Udine, Italy.; Department of Laboratory Medicine, Azienda Sanitaria Universitaria Friuli Centrale, 33100, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Krpan+B%22">Krpan B</searchLink>; Department of Medicine (DMED), University of Udine, Udine, Italy.; Department of Laboratory Medicine, Azienda Sanitaria Universitaria Friuli Centrale, 33100, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Gualandi+N%22">Gualandi N</searchLink>; Department of Medicine (DMED), University of Udine, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Moreal+C%22">Moreal C</searchLink>; Department of Medicine (DMED), University of Udine, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Perno+CF%22">Perno CF</searchLink>; Multimodal Laboratory Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.; Microbiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bernaschi+P%22">Bernaschi P</searchLink>; Microbiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Gennaro+C%22">Di Gennaro C</searchLink>; UOC Medicina/PS Ospedale A. Rizzoli, ASL Napoli 2 Nord, Lacco Ameno d'Ischia, Italy.<br /><searchLink fieldCode="AU" term="%22Arcamone+C%22">Arcamone C</searchLink>; UOC Medicina/PS Ospedale A. Rizzoli, ASL Napoli 2 Nord, Lacco Ameno d'Ischia, Italy.<br /><searchLink fieldCode="AU" term="%22Turco+S%22">Turco S</searchLink>; Università degli Studi della Campania Luigi Vanvitelli, Caserta, Italy.<br /><searchLink fieldCode="AU" term="%22Stanziola+MC%22">Stanziola MC</searchLink>; Dipartimento di Diagnostica di Laboratorio, Patologia Clinica Ospedale A. Rizzoli, ASL NA2 Nord, Lacco Ameno d'Ischia, Italy.<br /><searchLink fieldCode="AU" term="%22Manzi+R%22">Manzi R</searchLink>; Dipartimento di Diagnostica di Laboratorio, Patologia Clinica Ospedale A. Rizzoli, ASL NA2 Nord, Lacco Ameno d'Ischia, Italy.<br /><searchLink fieldCode="AU" term="%22Curcio+F%22">Curcio F</searchLink>; Department of Medicine (DMED), University of Udine, Udine, Italy.; Department of Laboratory Medicine, Azienda Sanitaria Universitaria Friuli Centrale, 33100, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Pipan+C%22">Pipan C</searchLink>; Department of Medicine (DMED), University of Udine, Udine, Italy.; Public Health Laboratory, Azienda Sanitaria Universitaria Friuli Centrale, 33100, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Tascini+C%22">Tascini C</searchLink>; Infectious Diseases Clinic, Azienda Sanitaria Universitaria Friuli Centrale, 33100, Udine, Italy.; Department of Medicine (DMED), University of Udine, Udine, Italy.
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