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Tumor-Intrinsic and Microenvironmental Determinants of Impaired Antitumor Immunity in Chromophobe Renal Cell Carcinoma.

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Title: Tumor-Intrinsic and Microenvironmental Determinants of Impaired Antitumor Immunity in Chromophobe Renal Cell Carcinoma.
Authors: Labaki C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.; Center of Molecular and Cellular Oncology (CMCO), Yale School of Medicine, New Haven, CT., Saad E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Center of Molecular and Cellular Oncology (CMCO), Yale School of Medicine, New Haven, CT., Madsen KN; Center of Molecular and Cellular Oncology (CMCO), Yale School of Medicine, New Haven, CT., Hobeika C; Department of Medicine, Cleveland Clinic Fairview Hospital, Cleveland, OH.; Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Bi K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Alchoueiry M; Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Camp S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Hou Y; Akoya Biosciences Inc, Marlborough, MA., Bakouny Z; Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY., Matar S; Department of Pathology, Brigham and Women's Hospital, Boston, MA., El Ahmar N; Department of Pathology, Brigham and Women's Hospital, Boston, MA., Nyman J; PathAI, Inc, Boston, MA., Zhang L; University of Shanghai for Science and Technology, Shanghai, China., Priolo C; Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Rout R; Center of Molecular and Cellular Oncology (CMCO), Yale School of Medicine, New Haven, CT., Daou M; Department of Medicine, Yale University, New Haven, CT., Khabibullin D; Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Salem S; Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Schindler N; Center of Molecular and Cellular Oncology (CMCO), Yale School of Medicine, New Haven, CT., Saliby RM; Center of Molecular and Cellular Oncology (CMCO), Yale School of Medicine, New Haven, CT.; Department of Medicine, Yale University, New Haven, CT., Meli K; RBC Capital Markets, New York, NY., Wells JC; BC Cancer Agency, Vancouver, Canada., Pimenta E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Takemura K; Tom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada., Park J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Eid M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Semaan K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Fu J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Denize T; Department of Pathology, Massachusetts General Hospital, Boston, MA., El Hajj Chehade R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Machaalani M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Nawfal R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Khatoun WD; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Saleh M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., El Masri J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Haddad NR; Johns Hopkins University School of Medicine, Baltimore, MD., Xu W; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., McGregor BA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Hirsch MS; Department of Pathology, Brigham and Women's Hospital, Boston, MA., Xie W; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Heng DYC; Tom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada., McDermott DF; Department of Medical Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA., Signoretti S; Department of Pathology, Brigham and Women's Hospital, Boston, MA., Van Allen EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Shukla SA; Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Texas, Houston, TX., Choueiri TK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Henske EP; Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Braun DA; Center of Molecular and Cellular Oncology (CMCO), Yale School of Medicine, New Haven, CT.
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2025 Aug 10; Vol. 43 (23), pp. 2639-2654. Date of Electronic Publication: 2025 Jul 02.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tumor-Intrinsic and Microenvironmental Determinants of Impaired Antitumor Immunity in Chromophobe Renal Cell Carcinoma.
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Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Alchoueiry+M%22">Alchoueiry M</searchLink>; Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Camp+S%22">Camp S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Hou+Y%22">Hou Y</searchLink>; Akoya Biosciences Inc, Marlborough, MA.<br /><searchLink fieldCode="AU" term="%22Bakouny+Z%22">Bakouny Z</searchLink>; Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Matar+S%22">Matar S</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22El+Ahmar+N%22">El Ahmar N</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Nyman+J%22">Nyman J</searchLink>; 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Center of Molecular and Cellular Oncology (CMCO), Yale School of Medicine, New Haven, CT.<br /><searchLink fieldCode="AU" term="%22Saliby+RM%22">Saliby RM</searchLink>; Center of Molecular and Cellular Oncology (CMCO), Yale School of Medicine, New Haven, CT.; Department of Medicine, Yale University, New Haven, CT.<br /><searchLink fieldCode="AU" term="%22Meli+K%22">Meli K</searchLink>; RBC Capital Markets, New York, NY.<br /><searchLink fieldCode="AU" term="%22Wells+JC%22">Wells JC</searchLink>; BC Cancer Agency, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Pimenta+E%22">Pimenta E</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Takemura+K%22">Takemura K</searchLink>; Tom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Eid+M%22">Eid M</searchLink>; 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