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The Somatic Mosaicism across Human Tissues Network.

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Title: The Somatic Mosaicism across Human Tissues Network.
Authors: Coorens THH; Broad Institute of MIT and Harvard, Cambridge, MA, USA. tcoorens@broadinstitute.org.; European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI), Cambridge, UK. tcoorens@broadinstitute.org., Oh JW; Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea. g1@yuhs.ac.; Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Korea. g1@yuhs.ac., Choi YA; Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea., Lim NS; Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea.; Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Korea., Zhao B; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.; Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Voshall A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.; Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Abyzov A; Department of Quantitative Health Sciences, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA., Antonacci-Fulton L; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA., Aparicio S; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; New York Genome Center, New York, NY, USA., Ardlie KG; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bell TJ; National Disease Research Interchange, Philadelphia, PA, USA., Bennett JT; Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA, USA.; Division of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle, WA, USA., Bernstein BE; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA., Blanchard TG; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA., Boyle AP; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Buenrostro JD; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Burns KH; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA., Chen F; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Chen R; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Choudhury S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Doddapaneni HV; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Eichler EE; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Evrony GD; Center for Human Genetics and Genomics, New York University Grossman School of Medicine, New York, NY, USA.; Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA.; Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY, USA., Faith MA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Behavioral Health, Johns Hopkins All Children's Hospital, Saint Petersburg, FL, USA., Fazzio TG; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Fulton RS; Department of Genetics, Washington University, St. Louis, MO, USA., Garber M; Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Gehlenborg N; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Germer S; New York Genome Center, New York, NY, USA., Getz G; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Gibbs RA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Hernandez RG; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Pediatric Health Equity Research, Johns Hopkins All Children's Hospital, Saint Petersburg, FL, USA., Jin F; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.; Department of Computer and Data Sciences, School of Engineering, Case Western Reserve University, Cleveland, OH, USA., Korbel JO; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.; Bridging Research Division on Mechanisms of Genomic Variation and Data Science, German Cancer Research Center, Heidelberg, Germany., Landau DA; New York Genome Center, New York, NY, USA.; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Lawson HA; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Lennon NJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Li H; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Li Y; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Loh PR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Marth G; Department of Human Genetics, University of Utah, Salt Lake City, UT, USA., McConnell MJ; Lieber Institute for Brain Development, Baltimore, MD, USA., Mills RE; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Montgomery SB; Department of Pathology, Stanford University, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA., Natarajan P; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Park PJ; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA., Satija R; New York Genome Center, New York, NY, USA.; Center for Genomics and Systems Biology, New York University, New York, NY, USA., Sedlazeck FJ; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Department of Computer Science, Rice University, Houston, TX, USA., Shao DD; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Boston Children's Hospital, Boston, MA, USA., Shen H; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA., Stergachis AB; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA., Underhill HR; Division of Medical Genetics, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Urban AE; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA., VonDran MW; National Disease Research Interchange, Philadelphia, PA, USA., Walsh CA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.; Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA., Wang T; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., Wu TP; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Roy M. and Phyllis Gough Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA., Zong C; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA., Lee EA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. ealice.lee@childrens.harvard.edu.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA. ealice.lee@childrens.harvard.edu.; Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA. ealice.lee@childrens.harvard.edu.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. ealice.lee@childrens.harvard.edu., Vaccarino FM; Child Study Center, Yale University, New Haven, CT, USA. flora.vaccarino@yale.edu.; Department of Neuroscience, Yale University, New Haven, CT, USA. flora.vaccarino@yale.edu.; Yale Stem Cell Center, Yale University, New Haven, CT, USA. flora.vaccarino@yale.edu.
Corporate Authors: Somatic Mosaicism across Human Tissues Network
Source: Nature [Nature] 2025 Jul; Vol. 643 (8070), pp. 47-59. Date of Electronic Publication: 2025 Jul 02.
Publication Type: Journal Article; Review; Research Support, N.I.H., Intramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Coorens+THH%22">Coorens THH</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA. tcoorens@broadinstitute.org.; European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI), Cambridge, UK. tcoorens@broadinstitute.org.<br /><searchLink fieldCode="AU" term="%22Oh+JW%22">Oh JW</searchLink>; Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea. g1@yuhs.ac.; Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Korea. g1@yuhs.ac.<br /><searchLink fieldCode="AU" term="%22Choi+YA%22">Choi YA</searchLink>; Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Lim+NS%22">Lim NS</searchLink>; Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea.; Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Zhao+B%22">Zhao B</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.; Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Voshall+A%22">Voshall A</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.; Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Abyzov+A%22">Abyzov A</searchLink>; Department of Quantitative Health Sciences, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Antonacci-Fulton+L%22">Antonacci-Fulton L</searchLink>; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Aparicio+S%22">Aparicio S</searchLink>; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; New York Genome Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ardlie+KG%22">Ardlie KG</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bell+TJ%22">Bell TJ</searchLink>; National Disease Research Interchange, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bennett+JT%22">Bennett JT</searchLink>; Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA, USA.; Division of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Bernstein+BE%22">Bernstein BE</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; 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Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+R%22">Chen R</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Choudhury+S%22">Choudhury S</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Doddapaneni+HV%22">Doddapaneni HV</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Eichler+EE%22">Eichler EE</searchLink>; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.; 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Department of Genetics, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Garber+M%22">Garber M</searchLink>; Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gehlenborg+N%22">Gehlenborg N</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Germer+S%22">Germer S</searchLink>; New York Genome Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Getz+G%22">Getz G</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gibbs+RA%22">Gibbs RA</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hernandez+RG%22">Hernandez RG</searchLink>; 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National Disease Research Interchange, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Walsh+CA%22">Walsh CA</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.; Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Wu+TP%22">Wu TP</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; 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            – D: 01
              M: 07
              Text: 2025 Jul
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4687
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              Value: 643
            – Type: issue
              Value: 8070
          Titles:
            – TitleFull: Nature
              Type: main
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