Polystyrene Nanoplastics Exacerbate HFD-induced MASLD by Reducing Cathepsin Activity and Triggering Large Vacuole Formation via Impaired Lysosomal Acidification.

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Title: Polystyrene Nanoplastics Exacerbate HFD-induced MASLD by Reducing Cathepsin Activity and Triggering Large Vacuole Formation via Impaired Lysosomal Acidification.
Authors: Ahn J; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea., Ryu K; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea., Kim H; Korea Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea., Seo HW; Infectious Diseases Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea., Jang M; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea., Kim SH; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea., Park Y; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.; Advanced Bioconvergence Department, Korea University of Science and Technology (UST), Daejeon 34141, Republic of Korea., Son MJ; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.; Advanced Bioconvergence Department, Korea University of Science and Technology (UST), Daejeon 34141, Republic of Korea., Lee HJ; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea., Kwon OS; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.; Advanced Bioconvergence Department, Korea University of Science and Technology (UST), Daejeon 34141, Republic of Korea., Chung KS; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.; Advanced Bioconvergence Department, Korea University of Science and Technology (UST), Daejeon 34141, Republic of Korea.; Biomedical Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
Source: International journal of biological sciences [Int J Biol Sci] 2025 Jun 09; Vol. 21 (9), pp. 3867-3885. Date of Electronic Publication: 2025 Jun 09 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE
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  Data: Polystyrene Nanoplastics Exacerbate HFD-induced MASLD by Reducing Cathepsin Activity and Triggering Large Vacuole Formation via Impaired Lysosomal Acidification.
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  Data: <searchLink fieldCode="AU" term="%22Ahn+J%22">Ahn J</searchLink>; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Ryu+K%22">Ryu K</searchLink>; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Korea Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Seo+HW%22">Seo HW</searchLink>; Infectious Diseases Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jang+M%22">Jang M</searchLink>; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+SH%22">Kim SH</searchLink>; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+Y%22">Park Y</searchLink>; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.; Advanced Bioconvergence Department, Korea University of Science and Technology (UST), Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Son+MJ%22">Son MJ</searchLink>; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.; Advanced Bioconvergence Department, Korea University of Science and Technology (UST), Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+HJ%22">Lee HJ</searchLink>; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+OS%22">Kwon OS</searchLink>; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.; Advanced Bioconvergence Department, Korea University of Science and Technology (UST), Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Chung+KS%22">Chung KS</searchLink>; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.; Advanced Bioconvergence Department, Korea University of Science and Technology (UST), Daejeon 34141, Republic of Korea.; Biomedical Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
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  Data: <searchLink fieldCode="JN" term="%22101235568%22">International journal of biological sciences</searchLink> [Int J Biol Sci] 2025 Jun 09; Vol. 21 (9), pp. 3867-3885. <i>Date of Electronic Publication: </i>2025 Jun 09 (<i>Print Publication: </i>2025).
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        Value: 10.7150/ijbs.108268
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        StartPage: 3867
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      – TitleFull: Polystyrene Nanoplastics Exacerbate HFD-induced MASLD by Reducing Cathepsin Activity and Triggering Large Vacuole Formation via Impaired Lysosomal Acidification.
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              Text: 2025 Jun 09
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