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Extracellular Vesicles Administered via Intrathecal Injection Mediate Safe Delivery of Nucleic Acids to the Central Nervous System for Gene Therapy.

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Title: Extracellular Vesicles Administered via Intrathecal Injection Mediate Safe Delivery of Nucleic Acids to the Central Nervous System for Gene Therapy.
Authors: Lam BWS; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Tan M; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Carmine Therapeutics, Singapore., Gao C; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Pham TT; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Tran LTN; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Nguyen LN; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Sidik H; Carmine Therapeutics, Singapore., Lim MBH; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Le AH; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Nguyen TTT; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Lim N; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Nguyen L; Department of Biochemistry, Hanoi University of Pharmacy, Hanoi, Vietnam., Nguyen TH; Center for Research and Production of Vaccines and Biologicals, Hanoi, Vietnam., Loh YH; Agency for Science, Technology and Research, Institute of Molecular and Cell Biology, Singapore., Usman MW; Carmine Therapeutics, Singapore., Le MTN; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Agency for Science, Technology and Research, Institute of Molecular and Cell Biology, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Source: Journal of extracellular vesicles [J Extracell Vesicles] 2025 Jul; Vol. 14 (7), pp. e70116.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101610479 Publication Model: Print Cited Medium: Internet ISSN: 2001-3078 (Electronic) Linking ISSN: 20013078 NLM ISO Abbreviation: J Extracell Vesicles Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Extracellular Vesicles Administered via Intrathecal Injection Mediate Safe Delivery of Nucleic Acids to the Central Nervous System for Gene Therapy.
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        Value: 10.1002/jev2.70116
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      – Code: eng
        Text: English
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        StartPage: e70116
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      – TitleFull: Extracellular Vesicles Administered via Intrathecal Injection Mediate Safe Delivery of Nucleic Acids to the Central Nervous System for Gene Therapy.
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            – D: 01
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              Text: 2025 Jul
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              Y: 2025
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