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Optimization of a sarbecovirus llama nanobody-antigen binding interface via a combined computational and phage display protein engineering approach.

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Title: Optimization of a sarbecovirus llama nanobody-antigen binding interface via a combined computational and phage display protein engineering approach.
Authors: Ramos KE; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Nandigrami P; Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461., Najafian A; Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461., Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Fiser A; Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jul 15; Vol. 122 (28), pp. e2426438122. Date of Electronic Publication: 2025 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Ramos+KE%22">Ramos KE</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.<br /><searchLink fieldCode="AU" term="%22Nandigrami+P%22">Nandigrami P</searchLink>; Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461.<br /><searchLink fieldCode="AU" term="%22Najafian+A%22">Najafian A</searchLink>; Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461.<br /><searchLink fieldCode="AU" term="%22Lai+JR%22">Lai JR</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.<br /><searchLink fieldCode="AU" term="%22Fiser+A%22">Fiser A</searchLink>; Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2025 Jul 15; Vol. 122 (28), pp. e2426438122. <i>Date of Electronic Publication: </i>2025 Jul 08.
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        Value: 10.1073/pnas.2426438122
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        Text: English
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              Text: 2025 Jul 15
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