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Proneural-mesenchymal hybrid glioblastoma cells are resistant to therapy and dependent on nuclear import.

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Title: Proneural-mesenchymal hybrid glioblastoma cells are resistant to therapy and dependent on nuclear import.
Authors: Bourmeau G; Institut Curie, INSERM U1339-CNRS UMR3666, Tumor Microenvironment Lab, Université Paris-Saclay, Orsay, France., Anezo O; Institut Curie, INSERM U1339-CNRS UMR3666, Tumor Microenvironment Lab, Université Paris-Saclay, Orsay, France., Raymond J; Nuffield Department of Medicine, Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK., Ballestín A; Institut Curie, INSERM U1339-CNRS UMR3666, Tumor Microenvironment Lab, Université Paris-Saclay, Orsay, France., Pichol-Thievend C; Institut Curie, INSERM U1339-CNRS UMR3666, Tumor Microenvironment Lab, Université Paris-Saclay, Orsay, France., Reveilles J; Institut Curie, INSERM U1339-CNRS UMR3666, Tumor Microenvironment Lab, Université Paris-Saclay, Orsay, France., Thomas A; Institut Curie, INSERM U1339-CNRS UMR3666, Tumor Microenvironment Lab, Université Paris-Saclay, Orsay, France., Wang L; Department of Computational and Quantitative Medicine, Hematologic Malignancies Research Institute and Beckman Research Institute, Duarte, California, USA., Miranda M; Single Cell Initiative, Institut Curie, PSL University, Paris, France.; Translational Research Department, Institut Curie, PSL University, Paris, France.; CNRS UMR3244, Institut Curie, PSL University, Paris, France., Moutaux E; Single Cell Initiative, Institut Curie, PSL University, Paris, France.; Translational Research Department, Institut Curie, PSL University, Paris, France.; CNRS UMR3244, Institut Curie, PSL University, Paris, France., Liva S; MINES ParisTeach, CBIO-Centre for Computational Biology, PSL Research University, Paris, France.; Institut Curie, PSL University, INSERM U900, Paris, France., Ribecco V; Institut Curie, INSERM U1339-CNRS UMR3666, Tumor Microenvironment Lab, Université Paris-Saclay, Orsay, France., Besse L; Institut Curie, Université PSL, CNRS UAR2016, Inserm US43, Université Paris-Saclay, Multimodal Imaging Center, Orsay, France., Dingli F; Institut Curie, PSL Research University, CurieCoreTech Spectrométrie de Masse Protéomique, Paris, France., Loew D; Institut Curie, PSL Research University, CurieCoreTech Spectrométrie de Masse Protéomique, Paris, France., Vallot C; Single Cell Initiative, Institut Curie, PSL University, Paris, France.; Translational Research Department, Institut Curie, PSL University, Paris, France.; CNRS UMR3244, Institut Curie, PSL University, Paris, France., Gargiulo G; Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany., Ravi VM; 3D-Brain Models Lab for Neurodegenerative Diseases, Medical Centre, University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center, University of Freiburg, Freiburg, Germany., Joseph K; 3D-Brain Models Lab for Neurodegenerative Diseases, Medical Centre, University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center, University of Freiburg, Freiburg, Germany., Seano G; Institut Curie, INSERM U1339-CNRS UMR3666, Tumor Microenvironment Lab, Université Paris-Saclay, Orsay, France.
Source: Neuro-oncology [Neuro Oncol] 2025 Nov 01; Vol. 27 (11), pp. 2876-2893.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE
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  Data: Proneural-mesenchymal hybrid glioblastoma cells are resistant to therapy and dependent on nuclear import.
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  Data: <searchLink fieldCode="AU" term="%22Bourmeau+G%22">Bourmeau G</searchLink>; Institut Curie, INSERM U1339-CNRS UMR3666, Tumor Microenvironment Lab, Université Paris-Saclay, Orsay, France.<br /><searchLink fieldCode="AU" term="%22Anezo+O%22">Anezo O</searchLink>; Institut Curie, INSERM U1339-CNRS UMR3666, Tumor Microenvironment Lab, Université Paris-Saclay, Orsay, France.<br /><searchLink fieldCode="AU" term="%22Raymond+J%22">Raymond J</searchLink>; Nuffield Department of Medicine, Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ballestín+A%22">Ballestín A</searchLink>; Institut Curie, INSERM U1339-CNRS UMR3666, Tumor Microenvironment Lab, Université Paris-Saclay, Orsay, France.<br /><searchLink fieldCode="AU" term="%22Pichol-Thievend+C%22">Pichol-Thievend C</searchLink>; Institut Curie, INSERM U1339-CNRS UMR3666, Tumor Microenvironment Lab, Université Paris-Saclay, Orsay, France.<br /><searchLink fieldCode="AU" term="%22Reveilles+J%22">Reveilles J</searchLink>; Institut Curie, INSERM U1339-CNRS UMR3666, Tumor Microenvironment Lab, Université Paris-Saclay, Orsay, France.<br /><searchLink fieldCode="AU" term="%22Thomas+A%22">Thomas A</searchLink>; Institut Curie, INSERM U1339-CNRS UMR3666, Tumor Microenvironment Lab, Université Paris-Saclay, Orsay, France.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Computational and Quantitative Medicine, Hematologic Malignancies Research Institute and Beckman Research Institute, Duarte, California, USA.<br /><searchLink fieldCode="AU" term="%22Miranda+M%22">Miranda M</searchLink>; Single Cell Initiative, Institut Curie, PSL University, Paris, France.; Translational Research Department, Institut Curie, PSL University, Paris, France.; CNRS UMR3244, Institut Curie, PSL University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Moutaux+E%22">Moutaux E</searchLink>; Single Cell Initiative, Institut Curie, PSL University, Paris, France.; Translational Research Department, Institut Curie, PSL University, Paris, France.; CNRS UMR3244, Institut Curie, PSL University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Liva+S%22">Liva S</searchLink>; MINES ParisTeach, CBIO-Centre for Computational Biology, PSL Research University, Paris, France.; Institut Curie, PSL University, INSERM U900, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ribecco+V%22">Ribecco V</searchLink>; Institut Curie, INSERM U1339-CNRS UMR3666, Tumor Microenvironment Lab, Université Paris-Saclay, Orsay, France.<br /><searchLink fieldCode="AU" term="%22Besse+L%22">Besse L</searchLink>; Institut Curie, Université PSL, CNRS UAR2016, Inserm US43, Université Paris-Saclay, Multimodal Imaging Center, Orsay, France.<br /><searchLink fieldCode="AU" term="%22Dingli+F%22">Dingli F</searchLink>; Institut Curie, PSL Research University, CurieCoreTech Spectrométrie de Masse Protéomique, Paris, France.<br /><searchLink fieldCode="AU" term="%22Loew+D%22">Loew D</searchLink>; Institut Curie, PSL Research University, CurieCoreTech Spectrométrie de Masse Protéomique, Paris, France.<br /><searchLink fieldCode="AU" term="%22Vallot+C%22">Vallot C</searchLink>; Single Cell Initiative, Institut Curie, PSL University, Paris, France.; Translational Research Department, Institut Curie, PSL University, Paris, France.; CNRS UMR3244, Institut Curie, PSL University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Gargiulo+G%22">Gargiulo G</searchLink>; Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Ravi+VM%22">Ravi VM</searchLink>; 3D-Brain Models Lab for Neurodegenerative Diseases, Medical Centre, University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Joseph+K%22">Joseph K</searchLink>; 3D-Brain Models Lab for Neurodegenerative Diseases, Medical Centre, University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Seano+G%22">Seano G</searchLink>; Institut Curie, INSERM U1339-CNRS UMR3666, Tumor Microenvironment Lab, Université Paris-Saclay, Orsay, France.
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