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Boosting CAR T-cell efficacy by blocking proteasomal degradation of membrane antigens.

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Title: Boosting CAR T-cell efficacy by blocking proteasomal degradation of membrane antigens.
Authors: Rieger L; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany., Irlinger K; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany., Füchsl F; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany., Tietje M; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany., Purcarea A; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany., Barbian N; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany., Faber M; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany., Vogelsang C; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany., Pfeuffer L; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.; Institute of Laboratory Medicine, TUM University Hospital, Technical University of Munich, Munich, Germany., Stotz S; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany., Karpiuk O; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany., Schulze T; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany., Augsburger A; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany., Glaisner N; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany., Konetzki V; Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany.; Department of Medicine II, University Hospital Würzburg, Würzburg, Germany., Friedel S; Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany.; Department of Medicine II, University Hospital Würzburg, Würzburg, Germany.; Bavarian Cancer Research Center, Munich, Germany., Besse A; Department of Medical Oncology and Hematology, Kantonsspital St. Gallen, St. Gallen, Switzerland.; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic., Besse L; Department of Medical Oncology and Hematology, Kantonsspital St. Gallen, St. Gallen, Switzerland.; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic., Driessen C; Department of Medical Oncology and Hematology, Kantonsspital St. Gallen, St. Gallen, Switzerland., Buchner M; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.; Institute of Laboratory Medicine, TUM University Hospital, Technical University of Munich, Munich, Germany., Schwamborn K; Institute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany., Steiger K; Institute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Deutsches Konsortium für Translationale Krebsforschung, Heidelberg, Germany.; Bavarian Cancer Research Center, Munich, Germany., Giansanti P; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.; Bavarian Center for Biomolecular Mass Spectrometry, School of Medicine and Health, Technical University of Munich, Munich, Germany., Theurich S; Bavarian Cancer Research Center, Munich, Germany.; Department of Medicine III, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Waldschmidt J; Department of Medicine II, University Hospital Würzburg, Würzburg, Germany., Kortüm KM; Department of Medicine II, University Hospital Würzburg, Würzburg, Germany., Hudecek M; Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany.; Department of Medicine II, University Hospital Würzburg, Würzburg, Germany., Einsele H; Department of Medicine II, University Hospital Würzburg, Würzburg, Germany.; Bavarian Cancer Research Center, Munich, Germany., Högner M; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany., Kuster B; Deutsches Konsortium für Translationale Krebsforschung, Heidelberg, Germany.; Bavarian Center for Biomolecular Mass Spectrometry, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany., Krackhardt AM; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.; Deutsches Konsortium für Translationale Krebsforschung, Heidelberg, Germany.; Malteser Krankenhaus St. Franziskus-Hospital, Flensburg, Germany., Hecker JS; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.; Bavarian Cancer Research Center, Munich, Germany., Bassermann F; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.; Deutsches Konsortium für Translationale Krebsforschung, Heidelberg, Germany.; Bavarian Cancer Research Center, Munich, Germany.
Source: Blood [Blood] 2026 Jan 29; Vol. 147 (5), pp. 534-546.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Rieger+L%22">Rieger L</searchLink>; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Irlinger+K%22">Irlinger K</searchLink>; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Füchsl+F%22">Füchsl F</searchLink>; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Tietje+M%22">Tietje M</searchLink>; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Purcarea+A%22">Purcarea A</searchLink>; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Barbian+N%22">Barbian N</searchLink>; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Faber+M%22">Faber M</searchLink>; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Vogelsang+C%22">Vogelsang C</searchLink>; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Pfeuffer+L%22">Pfeuffer L</searchLink>; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.; Institute of Laboratory Medicine, TUM University Hospital, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Stotz+S%22">Stotz S</searchLink>; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Karpiuk+O%22">Karpiuk O</searchLink>; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schulze+T%22">Schulze T</searchLink>; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Augsburger+A%22">Augsburger A</searchLink>; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Glaisner+N%22">Glaisner N</searchLink>; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Konetzki+V%22">Konetzki V</searchLink>; Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany.; Department of Medicine II, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Friedel+S%22">Friedel S</searchLink>; Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany.; Department of Medicine II, University Hospital Würzburg, Würzburg, Germany.; Bavarian Cancer Research Center, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Besse+A%22">Besse A</searchLink>; Department of Medical Oncology and Hematology, Kantonsspital St. Gallen, St. Gallen, Switzerland.; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Besse+L%22">Besse L</searchLink>; Department of Medical Oncology and Hematology, Kantonsspital St. Gallen, St. Gallen, Switzerland.; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Driessen+C%22">Driessen C</searchLink>; Department of Medical Oncology and Hematology, Kantonsspital St. Gallen, St. Gallen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Buchner+M%22">Buchner M</searchLink>; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.; Institute of Laboratory Medicine, TUM University Hospital, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schwamborn+K%22">Schwamborn K</searchLink>; Institute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Steiger+K%22">Steiger K</searchLink>; Institute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Deutsches Konsortium für Translationale Krebsforschung, Heidelberg, Germany.; Bavarian Cancer Research Center, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Giansanti+P%22">Giansanti P</searchLink>; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.; Bavarian Center for Biomolecular Mass Spectrometry, School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Theurich+S%22">Theurich S</searchLink>; Bavarian Cancer Research Center, Munich, Germany.; Department of Medicine III, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Waldschmidt+J%22">Waldschmidt J</searchLink>; Department of Medicine II, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kortüm+KM%22">Kortüm KM</searchLink>; Department of Medicine II, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hudecek+M%22">Hudecek M</searchLink>; Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany.; Department of Medicine II, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Einsele+H%22">Einsele H</searchLink>; Department of Medicine II, University Hospital Würzburg, Würzburg, Germany.; Bavarian Cancer Research Center, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Högner+M%22">Högner M</searchLink>; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kuster+B%22">Kuster B</searchLink>; Deutsches Konsortium für Translationale Krebsforschung, Heidelberg, Germany.; Bavarian Center for Biomolecular Mass Spectrometry, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Krackhardt+AM%22">Krackhardt AM</searchLink>; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.; Deutsches Konsortium für Translationale Krebsforschung, Heidelberg, Germany.; Malteser Krankenhaus St. Franziskus-Hospital, Flensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hecker+JS%22">Hecker JS</searchLink>; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.; Bavarian Cancer Research Center, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bassermann+F%22">Bassermann F</searchLink>; Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.; Deutsches Konsortium für Translationale Krebsforschung, Heidelberg, Germany.; Bavarian Cancer Research Center, Munich, Germany.
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