Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy.
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| Title: | Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy. |
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| Authors: | Phelps CM; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Graduate Program of Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Willis NB; Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA., Duan T; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Lee AH; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Graduate Program of Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Zhang Y; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Tsinghua Medicine, School of Medicine, Tsinghua University, Beijing, China., Rodriguez J DM; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Pandey SP; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Laughlin CR; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Rosen ABI; Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Joint CMU-Pitt PhD Program in Computational Biology, Carnegie Mellon-University of Pittsburgh, Pittsburgh, PA, USA., McPherson AC; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA., Shapira JH; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Randhawa SK; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Hedden L; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Richie TG; Division of Biology, Kansas State University, Manhattan, KS, USA., Wiechman HM; Division of Biology, Kansas State University, Manhattan, KS, USA., Bender MJ; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Nemet I; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH, USA., Zöhrer PA; Department of Nutritional Sciences, University of Vienna, Vienna, Austria; Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences (PhaNuSpo), University of Vienna, Vienna, Austria., Gottschalk RA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Schmitz KH; Department of Medicine and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Mullett SJ; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, USA., Gelhaus SL; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, USA., Davar D; Department of Medicine and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Zarour HM; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Medicine and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Hinterleitner R; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA; Institute of Infection, Inflammation, and Immunity, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Mossington T; Genetics and Microbiome Core, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Badger JH; Genetics and Microbiome Core, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Rodrigues RR; Genetics and Microbiome Core, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., McCulloch JA; Genetics and Microbiome Core, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Lee STM; Division of Biology, Kansas State University, Manhattan, KS, USA., Wagner KH; Department of Nutritional Sciences, University of Vienna, Vienna, Austria; Research Platform Active Ageing, University of Vienna, Vienna, Austria., Winter MG; Department of Internal Medicine, Division of Infectious Diseases, University of California, Davis, Davis, CA, USA., Winter SE; Department of Internal Medicine, Division of Infectious Diseases, University of California, Davis, Davis, CA, USA., Das J; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Pierre JF; Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA; Department of Surgery, University of Wisconsin-Madison, Madison, WI, USA., Trinchieri G; Genetics and Microbiome Core, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA; Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Meisel M; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. Electronic address: marlies@pitt.edu. |
| Source: | Cell [Cell] 2025 Oct 02; Vol. 188 (20), pp. 5680-5700.e28. Date of Electronic Publication: 2025 Jul 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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