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Design, synthesis, evaluation and X-ray structural studies of potent HIV-1 protease inhibitors containing substituted oxaspirocyclic carbamates as the P2 ligands.

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Title: Design, synthesis, evaluation and X-ray structural studies of potent HIV-1 protease inhibitors containing substituted oxaspirocyclic carbamates as the P2 ligands.
Authors: Ghosh AK; Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA. Electronic address: akghosh@purdue.edu., Shaktah R; Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA., Ghosh AK; Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA., Johnson ME; Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA., Bhandari D; Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA., Amano M; Department of Infectious Diseases, Kumamoto University School of Medicine, Kumamoto, 860-8556, Japan., Aoki M; Department of Medical Technology, Kumamoto University School of Medicine, Kumamoto, 861-5598, Japan., Kovalevsky A; Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA., Mitsuya H; Department of Infectious Diseases, Kumamoto University School of Medicine, Kumamoto, 860-8556, Japan; Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 05; Vol. 297, pp. 117880. Date of Electronic Publication: 2025 Jun 20.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Design, synthesis, evaluation and X-ray structural studies of potent HIV-1 protease inhibitors containing substituted oxaspirocyclic carbamates as the P2 ligands.
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  Data: <searchLink fieldCode="AU" term="%22Ghosh+AK%22">Ghosh AK</searchLink>; Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA. Electronic address: akghosh@purdue.edu.<br /><searchLink fieldCode="AU" term="%22Shaktah+R%22">Shaktah R</searchLink>; Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA.<br /><searchLink fieldCode="AU" term="%22Ghosh+AK%22">Ghosh AK</searchLink>; Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+ME%22">Johnson ME</searchLink>; Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA.<br /><searchLink fieldCode="AU" term="%22Bhandari+D%22">Bhandari D</searchLink>; Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA.<br /><searchLink fieldCode="AU" term="%22Amano+M%22">Amano M</searchLink>; Department of Infectious Diseases, Kumamoto University School of Medicine, Kumamoto, 860-8556, Japan.<br /><searchLink fieldCode="AU" term="%22Aoki+M%22">Aoki M</searchLink>; Department of Medical Technology, Kumamoto University School of Medicine, Kumamoto, 861-5598, Japan.<br /><searchLink fieldCode="AU" term="%22Kovalevsky+A%22">Kovalevsky A</searchLink>; Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA.<br /><searchLink fieldCode="AU" term="%22Mitsuya+H%22">Mitsuya H</searchLink>; Department of Infectious Diseases, Kumamoto University School of Medicine, Kumamoto, 860-8556, Japan; Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
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  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2025 Nov 05; Vol. 297, pp. 117880. <i>Date of Electronic Publication: </i>2025 Jun 20.
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              Text: 2025 Nov 05
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