Design, synthesis, evaluation and X-ray structural studies of potent HIV-1 protease inhibitors containing substituted oxaspirocyclic carbamates as the P2 ligands.
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| Title: | Design, synthesis, evaluation and X-ray structural studies of potent HIV-1 protease inhibitors containing substituted oxaspirocyclic carbamates as the P2 ligands. |
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| Authors: | Ghosh AK; Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA. Electronic address: akghosh@purdue.edu., Shaktah R; Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA., Ghosh AK; Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA., Johnson ME; Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA., Bhandari D; Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA., Amano M; Department of Infectious Diseases, Kumamoto University School of Medicine, Kumamoto, 860-8556, Japan., Aoki M; Department of Medical Technology, Kumamoto University School of Medicine, Kumamoto, 861-5598, Japan., Kovalevsky A; Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA., Mitsuya H; Department of Infectious Diseases, Kumamoto University School of Medicine, Kumamoto, 860-8556, Japan; Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA. |
| Source: | European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 05; Vol. 297, pp. 117880. Date of Electronic Publication: 2025 Jun 20. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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