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Oral apigenin prevents obesity-related muscular atrophy, but not obesity itself, in middle-aged rats fed a high-calorie diet.

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Title: Oral apigenin prevents obesity-related muscular atrophy, but not obesity itself, in middle-aged rats fed a high-calorie diet.
Authors: de Castro JM; Laboratory of Pain Pharmacology and Neuromodulation, Preclinical Investigations - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Medicine: Medical Sciences, Faculty of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil., da Silva Melo A; Laboratory of Pain Pharmacology and Neuromodulation, Preclinical Investigations - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Medicine: Medical Sciences, Faculty of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil., Silveira BL; Laboratory of Pain Pharmacology and Neuromodulation, Preclinical Investigations - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Medicine: Medical Sciences, Faculty of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil., Martins IAS; Laboratory of Pain Pharmacology and Neuromodulation, Preclinical Investigations - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Medicine: Medical Sciences, Faculty of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil., Marçal MM; Laboratory of Pain Pharmacology and Neuromodulation, Preclinical Investigations - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Medicine: Medical Sciences, Faculty of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil., Bosco TD; Laboratory of Pain Pharmacology and Neuromodulation, Preclinical Investigations - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Medicine: Medical Sciences, Faculty of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil., Keingeski MB; Postgraduate Program in Gastroenterology and Hepatology, UFRGS, Porto Alegre, Brazil; Experimental Laboratory of Hepatology and Gastroenterology, HCPA, Porto Alegre, Rio Grande do Sul, Brazil., Oliveira ECL; Postgraduate Program in Gastroenterology and Hepatology, UFRGS, Porto Alegre, Brazil; Experimental Laboratory of Hepatology and Gastroenterology, HCPA, Porto Alegre, Rio Grande do Sul, Brazil., Alvares-da-Silva MR; Postgraduate Program in Gastroenterology and Hepatology, UFRGS, Porto Alegre, Brazil; Experimental Laboratory of Hepatology and Gastroenterology, HCPA, Porto Alegre, Rio Grande do Sul, Brazil., Türck P; Laboratory of Cardiovascular Physiology, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil., Araujo ASDR; Laboratory of Cardiovascular Physiology, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil., Ayres LR; Laboratory of Inflammation, Metabolism and Exercise, and Laboratory of Cellular Physiology, Department of Physiology, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Human Movement Sciences, School of Physical Education, Physiotherapy and Dance, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil., Kowalewski LS; Laboratory of Inflammation, Metabolism and Exercise, and Laboratory of Cellular Physiology, Department of Physiology, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Human Movement Sciences, School of Physical Education, Physiotherapy and Dance, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil., Russo MKB; Laboratory of Inflammation, Metabolism and Exercise, and Laboratory of Cellular Physiology, Department of Physiology, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Human Movement Sciences, School of Physical Education, Physiotherapy and Dance, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil., Krause M; Laboratory of Inflammation, Metabolism and Exercise, and Laboratory of Cellular Physiology, Department of Physiology, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Human Movement Sciences, School of Physical Education, Physiotherapy and Dance, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil., Stein DJ; Laboratory of Pain Pharmacology and Neuromodulation, Preclinical Investigations - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Medicine: Medical Sciences, Faculty of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil., Torres ILS; Postgraduate Program in Gastroenterology and Hepatology, UFRGS, Porto Alegre, Brazil; Experimental Laboratory of Hepatology and Gastroenterology, HCPA, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: iltorres@hcpa.edu.br.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Aug; Vol. 189, pp. 118342. Date of Electronic Publication: 2025 Jul 12.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
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  Data: Oral apigenin prevents obesity-related muscular atrophy, but not obesity itself, in middle-aged rats fed a high-calorie diet.
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  Data: <searchLink fieldCode="AU" term="%22de+Castro+JM%22">de Castro JM</searchLink>; Laboratory of Pain Pharmacology and Neuromodulation, Preclinical Investigations - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Medicine: Medical Sciences, Faculty of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+Melo+A%22">da Silva Melo A</searchLink>; Laboratory of Pain Pharmacology and Neuromodulation, Preclinical Investigations - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Medicine: Medical Sciences, Faculty of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Silveira+BL%22">Silveira BL</searchLink>; Laboratory of Pain Pharmacology and Neuromodulation, Preclinical Investigations - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Medicine: Medical Sciences, Faculty of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Martins+IAS%22">Martins IAS</searchLink>; Laboratory of Pain Pharmacology and Neuromodulation, Preclinical Investigations - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Medicine: Medical Sciences, Faculty of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Marçal+MM%22">Marçal MM</searchLink>; Laboratory of Pain Pharmacology and Neuromodulation, Preclinical Investigations - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Medicine: Medical Sciences, Faculty of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Bosco+TD%22">Bosco TD</searchLink>; Laboratory of Pain Pharmacology and Neuromodulation, Preclinical Investigations - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Medicine: Medical Sciences, Faculty of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Keingeski+MB%22">Keingeski MB</searchLink>; Postgraduate Program in Gastroenterology and Hepatology, UFRGS, Porto Alegre, Brazil; Experimental Laboratory of Hepatology and Gastroenterology, HCPA, Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Oliveira+ECL%22">Oliveira ECL</searchLink>; Postgraduate Program in Gastroenterology and Hepatology, UFRGS, Porto Alegre, Brazil; Experimental Laboratory of Hepatology and Gastroenterology, HCPA, Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Alvares-da-Silva+MR%22">Alvares-da-Silva MR</searchLink>; Postgraduate Program in Gastroenterology and Hepatology, UFRGS, Porto Alegre, Brazil; Experimental Laboratory of Hepatology and Gastroenterology, HCPA, Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Türck+P%22">Türck P</searchLink>; Laboratory of Cardiovascular Physiology, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Araujo+ASDR%22">Araujo ASDR</searchLink>; Laboratory of Cardiovascular Physiology, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Ayres+LR%22">Ayres LR</searchLink>; Laboratory of Inflammation, Metabolism and Exercise, and Laboratory of Cellular Physiology, Department of Physiology, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Human Movement Sciences, School of Physical Education, Physiotherapy and Dance, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Kowalewski+LS%22">Kowalewski LS</searchLink>; Laboratory of Inflammation, Metabolism and Exercise, and Laboratory of Cellular Physiology, Department of Physiology, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Human Movement Sciences, School of Physical Education, Physiotherapy and Dance, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Russo+MKB%22">Russo MKB</searchLink>; Laboratory of Inflammation, Metabolism and Exercise, and Laboratory of Cellular Physiology, Department of Physiology, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Human Movement Sciences, School of Physical Education, Physiotherapy and Dance, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Krause+M%22">Krause M</searchLink>; Laboratory of Inflammation, Metabolism and Exercise, and Laboratory of Cellular Physiology, Department of Physiology, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Human Movement Sciences, School of Physical Education, Physiotherapy and Dance, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Stein+DJ%22">Stein DJ</searchLink>; Laboratory of Pain Pharmacology and Neuromodulation, Preclinical Investigations - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Medicine: Medical Sciences, Faculty of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Torres+ILS%22">Torres ILS</searchLink>; Postgraduate Program in Gastroenterology and Hepatology, UFRGS, Porto Alegre, Brazil; Experimental Laboratory of Hepatology and Gastroenterology, HCPA, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: iltorres@hcpa.edu.br.
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  Data: <searchLink fieldCode="JN" term="%228213295%22">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</searchLink> [Biomed Pharmacother] 2025 Aug; Vol. 189, pp. 118342. <i>Date of Electronic Publication: </i>2025 Jul 12.
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