Targeting complement C3/C3aR pathway restores rejuvenation factor PF4 and mitigates neurocognitive impairments in age-related perioperative neurocognitive disorders.
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| Title: | Targeting complement C3/C3aR pathway restores rejuvenation factor PF4 and mitigates neurocognitive impairments in age-related perioperative neurocognitive disorders. |
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| Authors: | Wang JL; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China., Ye CH; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China., Teng ZF; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China., Zhou K; Department of Urology, Fujian Medical University Union hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China., Pan LL; Fujian Institute of Hematology, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.; Fujian Provincial Key Laboratory on Hematology, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.; Department of Hematology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China., Ouyan MD; Department of Emergency Surgery, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China., Zheng Z; Department of Oral Surgery, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China., Lu M; Department of Oral Surgery, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China., Li SL; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China., Zhang J; Center for Advanced Vision Science, University of Virginia, Charlottesville, VA, USA.; Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA., Zheng PC; Fujian Center for Safety Evaluation of New Drug, Fujian Medical University, Fuzhou, Fujian, China.; Fujian Key Laboratory of Natural Medicine Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, China., Zhang J; Center for Advanced Vision Science, University of Virginia, Charlottesville, VA, USA.; Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA., Zhang H; Fujian Key Laboratory of Natural Medicine Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, China., Lin MH; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China., Zhang LC; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China., Huang SS; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China., Ren XN; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China., Zheng N; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China., Wei WL; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China., Zhao Z; Center for Cellular Regulation and Molecular Pharmaceutics, School of Life and Health Sciences, Hubei University of Technology, Wuhan, 430068, China. zhaozhenhuan@hbut.edu.cn., Wang SB; Center for Advanced Vision Science, University of Virginia, Charlottesville, VA, USA. sw3ta@virginia.edu.; Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA. sw3ta@virginia.edu., Lai ZM; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China. zl7mg@fjmu.edu.cn. |
| Source: | Molecular psychiatry [Mol Psychiatry] 2025 Nov; Vol. 30 (11), pp. 5192-5202. Date of Electronic Publication: 2025 Jul 14. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40659841 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Targeting complement C3/C3aR pathway restores rejuvenation factor PF4 and mitigates neurocognitive impairments in age-related perioperative neurocognitive disorders. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Wang+JL%22">Wang JL</searchLink>; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.<br /><searchLink fieldCode="AU" term="%22Ye+CH%22">Ye CH</searchLink>; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.<br /><searchLink fieldCode="AU" term="%22Teng+ZF%22">Teng ZF</searchLink>; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.<br /><searchLink fieldCode="AU" term="%22Zhou+K%22">Zhou K</searchLink>; Department of Urology, Fujian Medical University Union hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.<br /><searchLink fieldCode="AU" term="%22Pan+LL%22">Pan LL</searchLink>; Fujian Institute of Hematology, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.; Fujian Provincial Key Laboratory on Hematology, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.; Department of Hematology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.<br /><searchLink fieldCode="AU" term="%22Ouyan+MD%22">Ouyan MD</searchLink>; Department of Emergency Surgery, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.<br /><searchLink fieldCode="AU" term="%22Zheng+Z%22">Zheng Z</searchLink>; Department of Oral Surgery, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.<br /><searchLink fieldCode="AU" term="%22Lu+M%22">Lu M</searchLink>; Department of Oral Surgery, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.<br /><searchLink fieldCode="AU" term="%22Li+SL%22">Li SL</searchLink>; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Center for Advanced Vision Science, University of Virginia, Charlottesville, VA, USA.; Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+PC%22">Zheng PC</searchLink>; Fujian Center for Safety Evaluation of New Drug, Fujian Medical University, Fuzhou, Fujian, China.; Fujian Key Laboratory of Natural Medicine Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Center for Advanced Vision Science, University of Virginia, Charlottesville, VA, USA.; Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Fujian Key Laboratory of Natural Medicine Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Lin+MH%22">Lin MH</searchLink>; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.<br /><searchLink fieldCode="AU" term="%22Zhang+LC%22">Zhang LC</searchLink>; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.<br /><searchLink fieldCode="AU" term="%22Huang+SS%22">Huang SS</searchLink>; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.<br /><searchLink fieldCode="AU" term="%22Ren+XN%22">Ren XN</searchLink>; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.<br /><searchLink fieldCode="AU" term="%22Zheng+N%22">Zheng N</searchLink>; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.<br /><searchLink fieldCode="AU" term="%22Wei+WL%22">Wei WL</searchLink>; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Z%22">Zhao Z</searchLink>; Center for Cellular Regulation and Molecular Pharmaceutics, School of Life and Health Sciences, Hubei University of Technology, Wuhan, 430068, China. zhaozhenhuan@hbut.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+SB%22">Wang SB</searchLink>; Center for Advanced Vision Science, University of Virginia, Charlottesville, VA, USA. sw3ta@virginia.edu.; Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA. sw3ta@virginia.edu.<br /><searchLink fieldCode="AU" term="%22Lai+ZM%22">Lai ZM</searchLink>; Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, 350001, China. zl7mg@fjmu.edu.cn. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229607835%22">Molecular psychiatry</searchLink> [Mol Psychiatry] 2025 Nov; Vol. 30 (11), pp. 5192-5202. <i>Date of Electronic Publication: </i>2025 Jul 14. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group+Specialist+Journals%22">Nature Publishing Group Specialist Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9607835 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5578 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213594184%22">13594184 </searchLink><i>NLM ISO Abbreviation: </i>Mol Psychiatry <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40659841 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41380-025-03103-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 5192 Titles: – TitleFull: Targeting complement C3/C3aR pathway restores rejuvenation factor PF4 and mitigates neurocognitive impairments in age-related perioperative neurocognitive disorders. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wang JL – PersonEntity: Name: NameFull: Ye CH – PersonEntity: Name: NameFull: Teng ZF – PersonEntity: Name: NameFull: Zhou K – PersonEntity: Name: NameFull: Pan LL – PersonEntity: Name: NameFull: Ouyan MD – PersonEntity: Name: NameFull: Zheng Z – PersonEntity: Name: NameFull: Lu M – PersonEntity: Name: NameFull: Li SL – PersonEntity: Name: NameFull: Zhang J – PersonEntity: Name: NameFull: Zheng PC – PersonEntity: Name: NameFull: Zhang J – PersonEntity: Name: NameFull: Zhang H – PersonEntity: Name: NameFull: Lin MH – PersonEntity: Name: NameFull: Zhang LC – PersonEntity: Name: NameFull: Huang SS – PersonEntity: Name: NameFull: Ren XN – PersonEntity: Name: NameFull: Zheng N – PersonEntity: Name: NameFull: Wei WL – PersonEntity: Name: NameFull: Zhao Z – PersonEntity: Name: NameFull: Wang SB – PersonEntity: Name: NameFull: Lai ZM IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: 2025 Nov Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1476-5578 Numbering: – Type: volume Value: 30 – Type: issue Value: 11 Titles: – TitleFull: Molecular psychiatry Type: main |
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