Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-XL degradation to overcome cancer chemoresistance.
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| Title: | Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-X |
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| Authors: | Qin X; John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA.; Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA., Presser A; John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA.; Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA., Johnson L; John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA.; Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA., Matoba Y; Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA.; Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA., Shay BS; Department of Cell Biology, Harvard Medical School, Boston, MA.; Ludwig Center at Harvard, Harvard Medical School Boston, Boston, Ma., Xu W; Department of Cell Biology, Harvard Medical School, Boston, MA.; Ludwig Center at Harvard, Harvard Medical School Boston, Boston, Ma., Choiniere J; John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA.; Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA., Fraser C; John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA.; Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA., Garbicz F; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA.; Department of Immunology, Medical University of Warsaw, Poland., Spetz J; John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA.; Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA., Yu S; John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA.; Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA., Florido MHC; John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA.; Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA., Picucci F; John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA.; Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA., Yang Y; University of Texas San Antonio, San Antonio, TX., Drapkin R; Penn Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Carrasco R; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Hill SJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA.; Department of Medicine, Harvard Medical School, Boston MA., Liu J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA.; Department of Medicine, Harvard Medical School, Boston MA., Matulonis U; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA.; Department of Medicine, Harvard Medical School, Boston MA., Brugge J; Department of Cell Biology, Harvard Medical School, Boston, MA.; Ludwig Center at Harvard, Harvard Medical School Boston, Boston, Ma., Rueda BR; Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA.; Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA., Zhou D; University of Texas San Antonio, San Antonio, TX., Stover EH; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA.; Department of Medicine, Harvard Medical School, Boston MA., Sarosiek KA; John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA.; Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2025 Jun 26. Date of Electronic Publication: 2025 Jun 26. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40666988 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-X<subscript>L</subscript> degradation to overcome cancer chemoresistance. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Qin+X%22">Qin X</searchLink>; John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA.; Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA.<br /><searchLink fieldCode="AU" term="%22Presser+A%22">Presser A</searchLink>; John B. Little Center for Radiation Sciences, Harvard T.H. 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Chan School of Public Health; Boston MA.<br /><searchLink fieldCode="AU" term="%22Matoba+Y%22">Matoba Y</searchLink>; Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA.; Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Shay+BS%22">Shay BS</searchLink>; Department of Cell Biology, Harvard Medical School, Boston, MA.; Ludwig Center at Harvard, Harvard Medical School Boston, Boston, Ma.<br /><searchLink fieldCode="AU" term="%22Xu+W%22">Xu W</searchLink>; Department of Cell Biology, Harvard Medical School, Boston, MA.; Ludwig Center at Harvard, Harvard Medical School Boston, Boston, Ma.<br /><searchLink fieldCode="AU" term="%22Choiniere+J%22">Choiniere J</searchLink>; John B. Little Center for Radiation Sciences, Harvard T.H. 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Chan School of Public Health; Boston MA.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; University of Texas San Antonio, San Antonio, TX.<br /><searchLink fieldCode="AU" term="%22Drapkin+R%22">Drapkin R</searchLink>; Penn Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Carrasco+R%22">Carrasco R</searchLink>; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Hill+SJ%22">Hill SJ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA.; Department of Medicine, Harvard Medical School, Boston MA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA.; Department of Medicine, Harvard Medical School, Boston MA.<br /><searchLink fieldCode="AU" term="%22Matulonis+U%22">Matulonis U</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA.; Department of Medicine, Harvard Medical School, Boston MA.<br /><searchLink fieldCode="AU" term="%22Brugge+J%22">Brugge J</searchLink>; Department of Cell Biology, Harvard Medical School, Boston, MA.; Ludwig Center at Harvard, Harvard Medical School Boston, Boston, Ma.<br /><searchLink fieldCode="AU" term="%22Rueda+BR%22">Rueda BR</searchLink>; Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA.; Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Zhou+D%22">Zhou D</searchLink>; University of Texas San Antonio, San Antonio, TX.<br /><searchLink fieldCode="AU" term="%22Stover+EH%22">Stover EH</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA.; Department of Medicine, Harvard Medical School, Boston MA.<br /><searchLink fieldCode="AU" term="%22Sarosiek+KA%22">Sarosiek KA</searchLink>; John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA.; Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2025 Jun 26. <i>Date of Electronic Publication: </i>2025 Jun 26. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Preprint – Name: TitleSource Label: Journal Info Group: Src Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40666988 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1101/2025.06.24.661170 Languages: – Code: eng Text: English Titles: – TitleFull: Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-XL degradation to overcome cancer chemoresistance. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Qin X – PersonEntity: Name: NameFull: Presser A – PersonEntity: Name: NameFull: Johnson L – PersonEntity: Name: NameFull: Matoba Y – PersonEntity: Name: NameFull: Shay BS – PersonEntity: Name: NameFull: Xu W – PersonEntity: Name: NameFull: Choiniere J – PersonEntity: Name: NameFull: Fraser C – PersonEntity: Name: NameFull: Garbicz F – PersonEntity: Name: NameFull: Spetz J – PersonEntity: Name: NameFull: Yu S – PersonEntity: Name: NameFull: Florido MHC – PersonEntity: Name: NameFull: Picucci F – PersonEntity: Name: NameFull: Yang Y – PersonEntity: Name: NameFull: Drapkin R – PersonEntity: Name: NameFull: Carrasco R – PersonEntity: Name: NameFull: Hill SJ – PersonEntity: Name: NameFull: Liu J – PersonEntity: Name: NameFull: Matulonis U – PersonEntity: Name: NameFull: Brugge J – PersonEntity: Name: NameFull: Rueda BR – PersonEntity: Name: NameFull: Zhou D – PersonEntity: Name: NameFull: Stover EH – PersonEntity: Name: NameFull: Sarosiek KA IsPartOfRelationships: – BibEntity: Dates: – D: 26 M: 06 Text: 2025 Jun 26 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2692-8205 Titles: – TitleFull: BioRxiv : the preprint server for biology Type: main |
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