Reversal of MPPa-PDT Resistance in Osteosarcoma by Targeting ROCK2-Mediated Autophagy.

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Title: Reversal of MPPa-PDT Resistance in Osteosarcoma by Targeting ROCK2-Mediated Autophagy.
Authors: Yi X; Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, China.; Institute of Orthopedics of Jiangxi Province, Nanchang, China.; Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, Nanchang, China.; Institute of Minimally Invasive Orthopedics, Nanchang University, Nanchang, China., Deng X; Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, China.; Department of Rehabilitation, The Second Affiliated Hospital of Nanchang University, Nanchang, China., Deng J; Department of Vascular & Interventional & Lymphatic Surgery, The First Hospital of Nanchang, Nanchang, China., Li C; Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, China.; Institute of Orthopedics of Jiangxi Province, Nanchang, China.; Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, Nanchang, China.; Institute of Minimally Invasive Orthopedics, Nanchang University, Nanchang, China., Peng H; Department of Anorectal Surgery, Changcheng Hospital Affiliated to Nanchang University, Nanchang, China.; Department of Anorectal Surgery, No 908th Hospital of Chinese, Nanchang, China., Du Y; Department of Pharmacology, School of Pharmaceutical Science, Nanchang University, Nanchang, China., Li Q; Department of Pathology, The Second Affiliated Hospital of Nanchang University, Nanchang, China., Yan X; The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, China., Hu X; Department of Orthopedics, Pingxiang People's Hospital, PingXiang, China., Zheng Y; Department of Medical Genetics, The Second Affiliated Hospital of Nanchang University, Nanchang, China., Chen S; Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, China.; Institute of Orthopedics of Jiangxi Province, Nanchang, China.; Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, Nanchang, China.; Institute of Minimally Invasive Orthopedics, Nanchang University, Nanchang, China., Xiong T; Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, China.; Institute of Orthopedics of Jiangxi Province, Nanchang, China.; Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, Nanchang, China.; Institute of Minimally Invasive Orthopedics, Nanchang University, Nanchang, China., Xu D; Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China., Chen L; Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.; Medical Center for Cardiovascular Diseases, Neurological Diseases and Tumors of Jiangxi Province, The Second Affiliated Hospital of Nanchang University, Nanchang, China., Hao L; Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, China.; Institute of Orthopedics of Jiangxi Province, Nanchang, China.; Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, Nanchang, China.; Institute of Minimally Invasive Orthopedics, Nanchang University, Nanchang, China.
Source: Cell proliferation [Cell Prolif] 2026 Apr; Vol. 59 (4), pp. e70097. Date of Electronic Publication: 2025 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: Published for the Cell Kinetics Society, the European Study Group for Cell Proliferation, and the International Cell Cycle Society by Blackwell Scientific Publications Country of Publication: England NLM ID: 9105195 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2184 (Electronic) Linking ISSN: 09607722 NLM ISO Abbreviation: Cell Prolif Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Reversal of MPPa-PDT Resistance in Osteosarcoma by Targeting ROCK2-Mediated Autophagy.
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  Data: <searchLink fieldCode="AU" term="%22Yi+X%22">Yi X</searchLink>; Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, China.; Institute of Orthopedics of Jiangxi Province, Nanchang, China.; Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, Nanchang, China.; Institute of Minimally Invasive Orthopedics, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Deng+X%22">Deng X</searchLink>; Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, China.; Department of Rehabilitation, The Second Affiliated Hospital of Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Deng+J%22">Deng J</searchLink>; Department of Vascular & Interventional & Lymphatic Surgery, The First Hospital of Nanchang, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, China.; Institute of Orthopedics of Jiangxi Province, Nanchang, China.; Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, Nanchang, China.; Institute of Minimally Invasive Orthopedics, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Peng+H%22">Peng H</searchLink>; Department of Anorectal Surgery, Changcheng Hospital Affiliated to Nanchang University, Nanchang, China.; Department of Anorectal Surgery, No 908th Hospital of Chinese, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Du+Y%22">Du Y</searchLink>; Department of Pharmacology, School of Pharmaceutical Science, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Department of Pathology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Yan+X%22">Yan X</searchLink>; The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Department of Orthopedics, Pingxiang People's Hospital, PingXiang, China.<br /><searchLink fieldCode="AU" term="%22Zheng+Y%22">Zheng Y</searchLink>; Department of Medical Genetics, The Second Affiliated Hospital of Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, China.; Institute of Orthopedics of Jiangxi Province, Nanchang, China.; Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, Nanchang, China.; Institute of Minimally Invasive Orthopedics, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Xiong+T%22">Xiong T</searchLink>; Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, China.; Institute of Orthopedics of Jiangxi Province, Nanchang, China.; Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, Nanchang, China.; Institute of Minimally Invasive Orthopedics, Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Xu+D%22">Xu D</searchLink>; Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.; Medical Center for Cardiovascular Diseases, Neurological Diseases and Tumors of Jiangxi Province, The Second Affiliated Hospital of Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Hao+L%22">Hao L</searchLink>; Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, China.; Institute of Orthopedics of Jiangxi Province, Nanchang, China.; Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, Nanchang, China.; Institute of Minimally Invasive Orthopedics, Nanchang University, Nanchang, China.
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  Data: <searchLink fieldCode="JN" term="%229105195%22">Cell proliferation</searchLink> [Cell Prolif] 2026 Apr; Vol. 59 (4), pp. e70097. <i>Date of Electronic Publication: </i>2025 Jul 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Published+for+the+Cell+Kinetics+Society%2C+the+European+Study+Group+for+Cell+Proliferation%2C+and+the+International+Cell+Cycle+Society+by+Blackwell+Scientific+Publications%22">Published for the Cell Kinetics Society, the European Study Group for Cell Proliferation, and the International Cell Cycle Society by Blackwell Scientific Publications </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9105195 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1365-2184 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209607722%22">09607722 </searchLink><i>NLM ISO Abbreviation: </i>Cell Prolif <i>Subsets: </i>MEDLINE
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        Value: 10.1111/cpr.70097
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      – Code: eng
        Text: English
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      – TitleFull: Reversal of MPPa-PDT Resistance in Osteosarcoma by Targeting ROCK2-Mediated Autophagy.
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              M: 04
              Text: 2026 Apr
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