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Genome-wide associations spanning 194 in-hospital drug dosage change phenotypes highlight diverse genetic backgrounds in concurrent drug therapy.

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Title: Genome-wide associations spanning 194 in-hospital drug dosage change phenotypes highlight diverse genetic backgrounds in concurrent drug therapy.
Authors: Henriksen AP; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Rodríguez CL; Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Gentofte, Denmark., Currant H; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Nuffield Department for Population Health, University of Oxford, Oxford, UK., Louloudis I; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Biel JH; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Herrero-Zazo M; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK., Birney E; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK., Hansen TF; Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet-Glostrup, Copenhagen, Denmark., Mazzoni G; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Haue AD; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Heart Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Bundgaard H; The Heart Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark., Dinh KM; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Immunology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Quinn L; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Bruun MT; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark., Hjalgrim H; Danish Cancer Society Research Center, Copenhagen, Denmark.; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Mikkelsen C; Department of Clinical Immunology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Schwinn M; Department of Clinical Immunology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Pedersen OBV; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Ullum H; Statens Serum Institut, Copenhagen, Denmark., Ostrowski SR; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Banasik K; Department of Gynecology and Obstetrics, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark., Brunak S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Corporate Authors: DBDS Genomic Consortium
Source: Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2025 Jun 25; Vol. 28, pp. 239-248. Date of Electronic Publication: 2025 Jun 25 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology Country of Publication: Netherlands NLM ID: 101585369 Publication Model: eCollection Cited Medium: Print ISSN: 2001-0370 (Print) Linking ISSN: 20010370 NLM ISO Abbreviation: Comput Struct Biotechnol J Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Henriksen+AP%22">Henriksen AP</searchLink>; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Rodríguez+CL%22">Rodríguez CL</searchLink>; Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Gentofte, Denmark.<br /><searchLink fieldCode="AU" term="%22Currant+H%22">Currant H</searchLink>; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Nuffield Department for Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Louloudis+I%22">Louloudis I</searchLink>; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Biel+JH%22">Biel JH</searchLink>; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Herrero-Zazo+M%22">Herrero-Zazo M</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Birney+E%22">Birney E</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Hansen+TF%22">Hansen TF</searchLink>; Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet-Glostrup, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Mazzoni+G%22">Mazzoni G</searchLink>; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Haue+AD%22">Haue AD</searchLink>; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; 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