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Characterisation of between-cluster heterogeneity in malaria cluster randomised trials to inform future sample size calculations.

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Title: Characterisation of between-cluster heterogeneity in malaria cluster randomised trials to inform future sample size calculations.
Authors: Biggs J; International Statistics and Epidemiology Group, Department of Infectious Disease Epidemiology and International Health, London School of Hygiene and Tropical Medicine (LSHTM), London, UK. joseph.biggs1@lshtm.ac.uk., Challenger JD; Medical research Council (MRC) Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, UK., Dee D; Medical research Council (MRC) Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, UK., Elobolobo E; Centro de Investigaçao em Saúde de Manhiça, Manhiça, Mozambique., Chaccour C; Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; CIBER de Enfermedades Infecciosas, Madrid, Spain.; Universidad de Navarra, Pamplona, Spain., Saute F; Centro de Investigaçao em Saúde de Manhiça, Manhiça, Mozambique., Staedke SG; Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK.; Kenya Medical Research Institute (KEMRI) Centre for Global Health Research, Kisumu, Kenya., Vilakati S; National Malaria Control Programme, Ministry of Health, Manzini, Eswatini., Chung JB; Department of Epidemiology and Population Health, Stanford University, Stanford, USA.; Chan Zuckerberg Biohub, San Francisco, USA., Hsiang MS; Chan Zuckerberg Biohub, San Francisco, USA.; Malaria Elimination Initiative, Institute for Global Health Sciences, University of California, San Francisco (UCSF), San Francisco, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco (UCSF), San Francisco, USA., Dabira ED; Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine (LSHTM), Disease Control & Elimination Theme, Fajara, The Gambia., Erhart A; Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine (LSHTM), Disease Control & Elimination Theme, Fajara, The Gambia., D'Alessandro U; Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine (LSHTM), Disease Control & Elimination Theme, Fajara, The Gambia., Tripura R; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Peto TJ; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Von Seidlein L; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Mukaka M; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Mosha J; Department of Parasitology, National Institute for Medical Research, Mwanza, Tanzania., Protopopoff N; Department of Epidemiology and Public Health, Swiss Tropical & Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland., Accrombessi M; Population Services International (PSI), Malaria department, Cotonou, Benin.; Institut de Recherche Clinique du Benin (IRCB), Clinical Research department, Abomey-Calavi, Benin., Hayes R; International Statistics and Epidemiology Group, Department of Infectious Disease Epidemiology and International Health, London School of Hygiene and Tropical Medicine (LSHTM), London, UK., Churcher TS; Medical research Council (MRC) Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, UK., Cook J; International Statistics and Epidemiology Group, Department of Infectious Disease Epidemiology and International Health, London School of Hygiene and Tropical Medicine (LSHTM), London, UK.
Source: Nature communications [Nat Commun] 2025 Jul 18; Vol. 16 (1), pp. 6615. Date of Electronic Publication: 2025 Jul 18.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Characterisation of between-cluster heterogeneity in malaria cluster randomised trials to inform future sample size calculations.
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  Data: <searchLink fieldCode="AU" term="%22Biggs+J%22">Biggs J</searchLink>; International Statistics and Epidemiology Group, Department of Infectious Disease Epidemiology and International Health, London School of Hygiene and Tropical Medicine (LSHTM), London, UK. joseph.biggs1@lshtm.ac.uk.<br /><searchLink fieldCode="AU" term="%22Challenger+JD%22">Challenger JD</searchLink>; Medical research Council (MRC) Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Dee+D%22">Dee D</searchLink>; Medical research Council (MRC) Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Elobolobo+E%22">Elobolobo E</searchLink>; Centro de Investigaçao em Saúde de Manhiça, Manhiça, Mozambique.<br /><searchLink fieldCode="AU" term="%22Chaccour+C%22">Chaccour C</searchLink>; Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; CIBER de Enfermedades Infecciosas, Madrid, Spain.; Universidad de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Saute+F%22">Saute F</searchLink>; Centro de Investigaçao em Saúde de Manhiça, Manhiça, Mozambique.<br /><searchLink fieldCode="AU" term="%22Staedke+SG%22">Staedke SG</searchLink>; Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK.; Kenya Medical Research Institute (KEMRI) Centre for Global Health Research, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Vilakati+S%22">Vilakati S</searchLink>; National Malaria Control Programme, Ministry of Health, Manzini, Eswatini.<br /><searchLink fieldCode="AU" term="%22Chung+JB%22">Chung JB</searchLink>; Department of Epidemiology and Population Health, Stanford University, Stanford, USA.; Chan Zuckerberg Biohub, San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Hsiang+MS%22">Hsiang MS</searchLink>; Chan Zuckerberg Biohub, San Francisco, USA.; Malaria Elimination Initiative, Institute for Global Health Sciences, University of California, San Francisco (UCSF), San Francisco, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco (UCSF), San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Dabira+ED%22">Dabira ED</searchLink>; Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine (LSHTM), Disease Control & Elimination Theme, Fajara, The Gambia.<br /><searchLink fieldCode="AU" term="%22Erhart+A%22">Erhart A</searchLink>; Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine (LSHTM), Disease Control & Elimination Theme, Fajara, The Gambia.<br /><searchLink fieldCode="AU" term="%22D'Alessandro+U%22">D'Alessandro U</searchLink>; Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine (LSHTM), Disease Control & Elimination Theme, Fajara, The Gambia.<br /><searchLink fieldCode="AU" term="%22Tripura+R%22">Tripura R</searchLink>; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Peto+TJ%22">Peto TJ</searchLink>; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Von+Seidlein+L%22">Von Seidlein L</searchLink>; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Mukaka+M%22">Mukaka M</searchLink>; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Mosha+J%22">Mosha J</searchLink>; Department of Parasitology, National Institute for Medical Research, Mwanza, Tanzania.<br /><searchLink fieldCode="AU" term="%22Protopopoff+N%22">Protopopoff N</searchLink>; Department of Epidemiology and Public Health, Swiss Tropical & Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Accrombessi+M%22">Accrombessi M</searchLink>; Population Services International (PSI), Malaria department, Cotonou, Benin.; Institut de Recherche Clinique du Benin (IRCB), Clinical Research department, Abomey-Calavi, Benin.<br /><searchLink fieldCode="AU" term="%22Hayes+R%22">Hayes R</searchLink>; International Statistics and Epidemiology Group, Department of Infectious Disease Epidemiology and International Health, London School of Hygiene and Tropical Medicine (LSHTM), London, UK.<br /><searchLink fieldCode="AU" term="%22Churcher+TS%22">Churcher TS</searchLink>; Medical research Council (MRC) Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Cook+J%22">Cook J</searchLink>; International Statistics and Epidemiology Group, Department of Infectious Disease Epidemiology and International Health, London School of Hygiene and Tropical Medicine (LSHTM), London, UK.
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