Bedaquiline, delamanid, linezolid, and clofazimine for rifampicin-resistant and fluoroquinolone-resistant tuberculosis (endTB-Q): an open-label, multicentre, stratified, non-inferiority, randomised, controlled, phase 3 trial.
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| Title: | Bedaquiline, delamanid, linezolid, and clofazimine for rifampicin-resistant and fluoroquinolone-resistant tuberculosis (endTB-Q): an open-label, multicentre, stratified, non-inferiority, randomised, controlled, phase 3 trial. |
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| Authors: | Guglielmetti L; Médecins Sans Frontières, Paris, France; Department of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy. Electronic address: lorenzo.guglielmetti@paris.msf.org., Khan U; Interactive Research and Development Global, Singapore; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University Montreal, Montreal, QC, Canada., Velásquez GE; Center for Tuberculosis, Institute for Global Health Sciences, University of California, San Francisco, CA, USA; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, CA, USA., Gouillou M; Epicentre, Paris, France., Ali MH; Interactive Research and Development, Karachi, Pakistan., Amjad S; Interactive Research and Development, Karachi, Pakistan., Kamal F; Interactive Research and Development, Karachi, Pakistan., Abubakirov A; National Scientific Center of Phthisiopulmonology, Almaty, Kazakhstan., Ardizzoni E; Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Baudin E; Epicentre, Paris, France., Bektassov S; National Scientific Center of Phthisiopulmonology, Almaty, Kazakhstan., Berry C; Médecins Sans Frontières, London, UK., Bonnet M; Translational Research on HIV and Endemic and Emerging Infectious Diseases, Montpellier Université de Montpellier, Institut de Recherche pour le Développement, INSERM, Montpellier, France., Chavan V; Médecins Sans Frontières, Mumbai, India., Coutisson S; Médecins Sans Frontières, Geneva, Switzerland., Dakenova Z; City Center of Phthisiopulmonology, Astana, Kazakhstan., de Jong BC; Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Dinh LV; National Lung Hospital, Hanoi, Viet Nam., Ferlazzo G; Médecins Sans Frontières, Geneva, Switzerland., Kirakosyan O; Department of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany., Lachenal N; Médecins Sans Frontières, Geneva, Switzerland., Lecca L; Socios en Salud-Sucursal, San Isidro, Peru; Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA., McIlleron H; Department of Medicine, University of Cape Town, Cape Town, South Africa., Mikanda KK; Partners In Health Lesotho, Maseru, Lesotho., Mucching-Toscano S; Socios en Salud-Sucursal, San Isidro, Peru., Mulders W; Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Mushtaque H; The Indus Hospital and Health Network, Karachi, Pakistan., Nahid P; Center for Tuberculosis, Institute for Global Health Sciences, University of California, San Francisco, CA, USA., Nguyen DV; Hanoi Lung Hospital, Hanoi, Viet Nam., Nguyen NV; National Lung Hospital, Hanoi, Viet Nam., Oyewusi L; Partners In Health Lesotho, Maseru, Lesotho., Motta I; MRC Clinical Trials Unit, UCL, London, UK; Médecins Sans Frontières, Geneva, Switzerland., Panda S; Indian Council of Medical Research, New Delhi, India., Patil S; National AIDS Research Institute, Pune, India., Pham TH; Hanoi Lung Hospital, Hanoi, Viet Nam., Phan DT; Pham Ngoc Thach Hospital, Ho Chi Minh City, Viet Nam., Phan HTT; Center for Tuberculosis, Institute for Global Health Sciences, University of California, San Francisco, CA, USA; Hanoi Lung Hospital, Hanoi, Viet Nam; Vietnam National TB Program University of California San Francisco Research Collaboration Unit, Center for Promotion of Advancement of Society Hanoi, Hanoi, Viet Nam., Phillips PPJ; Center for Tuberculosis, Institute for Global Health Sciences, University of California, San Francisco, CA, USA., Ruiz J; Socios en Salud-Sucursal, San Isidro, Peru., Rupasinghe P; Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Salahuddin N; The Indus Hospital and Health Network, Karachi, Pakistan., Sanchez-Garavito E; Socios en Salud-Sucursal, San Isidro, Peru; Hospital Nacional Sergio E Bernales, Comas, Peru., Seung KJ; Division of Global Health Equity, Brigham and Women's Hospital, MA, USA., Asfaw MT; Partners In Health Lesotho, Maseru, Lesotho., Vargas Vasquez D; Hospital Nacional Hipólito Unanue, El Agustino, Peru; Socios en Salud-Sucursal, San Isidro, Peru., Rich ML; Partners In Health, Boston, MA, USA; Division of Global Health Equity, Brigham and Women's Hospital, MA, USA., Varaine F; Médecins Sans Frontières, Paris, France., Mitnick CD; Partners In Health, Boston, MA, USA; Division of Global Health Equity, Brigham and Women's Hospital, MA, USA; Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA. |
| Corporate Authors: | endTB-Q Clinical Trial Team |
| Source: | The Lancet. Respiratory medicine [Lancet Respir Med] 2025 Sep; Vol. 13 (9), pp. 809-820. Date of Electronic Publication: 2025 Jul 16. |
| Publication Type: | Clinical Trial, Phase III; Equivalence Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 101605555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2619 (Electronic) Linking ISSN: 22132600 NLM ISO Abbreviation: Lancet Respir Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40683298 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Bedaquiline, delamanid, linezolid, and clofazimine for rifampicin-resistant and fluoroquinolone-resistant tuberculosis (endTB-Q): an open-label, multicentre, stratified, non-inferiority, randomised, controlled, phase 3 trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Guglielmetti+L%22">Guglielmetti L</searchLink>; Médecins Sans Frontières, Paris, France; Department of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy. Electronic address: lorenzo.guglielmetti@paris.msf.org.<br /><searchLink fieldCode="AU" term="%22Khan+U%22">Khan U</searchLink>; Interactive Research and Development Global, Singapore; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University Montreal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Velásquez+GE%22">Velásquez GE</searchLink>; Center for Tuberculosis, Institute for Global Health Sciences, University of California, San Francisco, CA, USA; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gouillou+M%22">Gouillou M</searchLink>; Epicentre, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ali+MH%22">Ali MH</searchLink>; Interactive Research and Development, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Amjad+S%22">Amjad S</searchLink>; Interactive Research and Development, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Kamal+F%22">Kamal F</searchLink>; Interactive Research and Development, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Abubakirov+A%22">Abubakirov A</searchLink>; National Scientific Center of Phthisiopulmonology, Almaty, Kazakhstan.<br /><searchLink fieldCode="AU" term="%22Ardizzoni+E%22">Ardizzoni E</searchLink>; Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Baudin+E%22">Baudin E</searchLink>; Epicentre, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bektassov+S%22">Bektassov S</searchLink>; National Scientific Center of Phthisiopulmonology, Almaty, Kazakhstan.<br /><searchLink fieldCode="AU" term="%22Berry+C%22">Berry C</searchLink>; Médecins Sans Frontières, London, UK.<br /><searchLink fieldCode="AU" term="%22Bonnet+M%22">Bonnet M</searchLink>; Translational Research on HIV and Endemic and Emerging Infectious Diseases, Montpellier Université de Montpellier, Institut de Recherche pour le Développement, INSERM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Chavan+V%22">Chavan V</searchLink>; Médecins Sans Frontières, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Coutisson+S%22">Coutisson S</searchLink>; Médecins Sans Frontières, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dakenova+Z%22">Dakenova Z</searchLink>; City Center of Phthisiopulmonology, Astana, Kazakhstan.<br /><searchLink fieldCode="AU" term="%22de+Jong+BC%22">de Jong BC</searchLink>; Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Dinh+LV%22">Dinh LV</searchLink>; National Lung Hospital, Hanoi, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Ferlazzo+G%22">Ferlazzo G</searchLink>; Médecins Sans Frontières, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kirakosyan+O%22">Kirakosyan O</searchLink>; Department of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.<br /><searchLink fieldCode="AU" term="%22Lachenal+N%22">Lachenal N</searchLink>; Médecins Sans Frontières, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lecca+L%22">Lecca L</searchLink>; Socios en Salud-Sucursal, San Isidro, Peru; Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22McIlleron+H%22">McIlleron H</searchLink>; Department of Medicine, University of Cape Town, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Mikanda+KK%22">Mikanda KK</searchLink>; Partners In Health Lesotho, Maseru, Lesotho.<br /><searchLink fieldCode="AU" term="%22Mucching-Toscano+S%22">Mucching-Toscano S</searchLink>; Socios en Salud-Sucursal, San Isidro, Peru.<br /><searchLink fieldCode="AU" term="%22Mulders+W%22">Mulders W</searchLink>; Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Mushtaque+H%22">Mushtaque H</searchLink>; The Indus Hospital and Health Network, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Nahid+P%22">Nahid P</searchLink>; Center for Tuberculosis, Institute for Global Health Sciences, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+DV%22">Nguyen DV</searchLink>; Hanoi Lung Hospital, Hanoi, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Nguyen+NV%22">Nguyen NV</searchLink>; National Lung Hospital, Hanoi, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Oyewusi+L%22">Oyewusi L</searchLink>; Partners In Health Lesotho, Maseru, Lesotho.<br /><searchLink fieldCode="AU" term="%22Motta+I%22">Motta I</searchLink>; MRC Clinical Trials Unit, UCL, London, UK; Médecins Sans Frontières, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Panda+S%22">Panda S</searchLink>; Indian Council of Medical Research, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Patil+S%22">Patil S</searchLink>; National AIDS Research Institute, Pune, India.<br /><searchLink fieldCode="AU" term="%22Pham+TH%22">Pham TH</searchLink>; Hanoi Lung Hospital, Hanoi, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Phan+DT%22">Phan DT</searchLink>; Pham Ngoc Thach Hospital, Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Phan+HTT%22">Phan HTT</searchLink>; Center for Tuberculosis, Institute for Global Health Sciences, University of California, San Francisco, CA, USA; Hanoi Lung Hospital, Hanoi, Viet Nam; Vietnam National TB Program University of California San Francisco Research Collaboration Unit, Center for Promotion of Advancement of Society Hanoi, Hanoi, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Phillips+PPJ%22">Phillips PPJ</searchLink>; Center for Tuberculosis, Institute for Global Health Sciences, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ruiz+J%22">Ruiz J</searchLink>; Socios en Salud-Sucursal, San Isidro, Peru.<br /><searchLink fieldCode="AU" term="%22Rupasinghe+P%22">Rupasinghe P</searchLink>; Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Salahuddin+N%22">Salahuddin N</searchLink>; The Indus Hospital and Health Network, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Sanchez-Garavito+E%22">Sanchez-Garavito E</searchLink>; Socios en Salud-Sucursal, San Isidro, Peru; Hospital Nacional Sergio E Bernales, Comas, Peru.<br /><searchLink fieldCode="AU" term="%22Seung+KJ%22">Seung KJ</searchLink>; Division of Global Health Equity, Brigham and Women's Hospital, MA, USA.<br /><searchLink fieldCode="AU" term="%22Asfaw+MT%22">Asfaw MT</searchLink>; Partners In Health Lesotho, Maseru, Lesotho.<br /><searchLink fieldCode="AU" term="%22Vargas+Vasquez+D%22">Vargas Vasquez D</searchLink>; Hospital Nacional Hipólito Unanue, El Agustino, Peru; Socios en Salud-Sucursal, San Isidro, Peru.<br /><searchLink fieldCode="AU" term="%22Rich+ML%22">Rich ML</searchLink>; Partners In Health, Boston, MA, USA; Division of Global Health Equity, Brigham and Women's Hospital, MA, USA.<br /><searchLink fieldCode="AU" term="%22Varaine+F%22">Varaine F</searchLink>; Médecins Sans Frontières, Paris, France.<br /><searchLink fieldCode="AU" term="%22Mitnick+CD%22">Mitnick CD</searchLink>; Partners In Health, Boston, MA, USA; Division of Global Health Equity, Brigham and Women's Hospital, MA, USA; Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22endTB-Q+Clinical+Trial+Team%22">endTB-Q Clinical Trial Team</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101605555%22">The Lancet. Respiratory medicine</searchLink> [Lancet Respir Med] 2025 Sep; Vol. 13 (9), pp. 809-820. <i>Date of Electronic Publication: </i>2025 Jul 16. – Name: TypePub Label: Publication Type Group: TypPub Data: Clinical Trial, Phase III; Equivalence Trial; Journal Article; Multicenter Study; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101605555 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2213-2619 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222132600%22">22132600 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Respir Med <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40683298 |
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