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Extracellular LCN2 Binding to 24p3R in Astrocytes Impedes α-Synuclein Endocytosis in Parkinson's Disease.

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Title: Extracellular LCN2 Binding to 24p3R in Astrocytes Impedes α-Synuclein Endocytosis in Parkinson's Disease.
Authors: Jiao YY; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China., Tian T; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China., Zhu Z; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China., Cao L; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China.; Changzhou Second People's Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213000, P. R. China.; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, P. R. China., Liu Y; Department of Pharmacology, Nanjing University of Chinese Medicine, Nanjing, 210023, P. R. China., Wang RA; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China., Zhou ZY; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China., Wang C; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China.; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, P. R. China., Zhang KZ; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, P. R. China., Lu X; Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P. R. China., Yun WW; Changzhou Second People's Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213000, P. R. China., Lu YM; Department of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, P. R. China., Hu G; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China., Du RH; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China.; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, P. R. China., Lu M; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China.; Changzhou Second People's Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213000, P. R. China.; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, P. R. China.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Oct; Vol. 12 (39), pp. e01694. Date of Electronic Publication: 2025 Jul 21.
Publication Type: Journal Article
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Extracellular LCN2 Binding to 24p3R in Astrocytes Impedes α-Synuclein Endocytosis in Parkinson's Disease.
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  Data: <searchLink fieldCode="AU" term="%22Jiao+YY%22">Jiao YY</searchLink>; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China.<br /><searchLink fieldCode="AU" term="%22Tian+T%22">Tian T</searchLink>; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China.<br /><searchLink fieldCode="AU" term="%22Zhu+Z%22">Zhu Z</searchLink>; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China.<br /><searchLink fieldCode="AU" term="%22Cao+L%22">Cao L</searchLink>; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China.; Changzhou Second People's Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213000, P. R. China.; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, P. R. China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Pharmacology, Nanjing University of Chinese Medicine, Nanjing, 210023, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wang+RA%22">Wang RA</searchLink>; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China.<br /><searchLink fieldCode="AU" term="%22Zhou+ZY%22">Zhou ZY</searchLink>; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China.; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, P. R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+KZ%22">Zhang KZ</searchLink>; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, P. R. China.<br /><searchLink fieldCode="AU" term="%22Lu+X%22">Lu X</searchLink>; Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P. R. China.<br /><searchLink fieldCode="AU" term="%22Yun+WW%22">Yun WW</searchLink>; Changzhou Second People's Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213000, P. R. China.<br /><searchLink fieldCode="AU" term="%22Lu+YM%22">Lu YM</searchLink>; Department of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, P. R. China.<br /><searchLink fieldCode="AU" term="%22Hu+G%22">Hu G</searchLink>; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China.<br /><searchLink fieldCode="AU" term="%22Du+RH%22">Du RH</searchLink>; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China.; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, P. R. China.<br /><searchLink fieldCode="AU" term="%22Lu+M%22">Lu M</searchLink>; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, P. R. China.; Changzhou Second People's Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213000, P. R. China.; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, P. R. China.
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  Data: <searchLink fieldCode="JN" term="%22101664569%22">Advanced science (Weinheim, Baden-Wurttemberg, Germany)</searchLink> [Adv Sci (Weinh)] 2025 Oct; Vol. 12 (39), pp. e01694. <i>Date of Electronic Publication: </i>2025 Jul 21.
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        Value: 10.1002/advs.202501694
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      – TitleFull: Extracellular LCN2 Binding to 24p3R in Astrocytes Impedes α-Synuclein Endocytosis in Parkinson's Disease.
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