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Longitudinal Analysis of Somatic Mosaicism and Clonal Hematopoiesis in Cryopyrin-Associated Periodic Syndrome.

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Title: Longitudinal Analysis of Somatic Mosaicism and Clonal Hematopoiesis in Cryopyrin-Associated Periodic Syndrome.
Authors: Kato K; Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan., Honda Y; Department of Pediatrics, Graduate School of Medicine, Institute for the Advanced Study of Human Biology, and Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Kamatani T; Department of AI Technology Development, M&D Data Science Center, Institute of Integrated Research, Institute of Science Tokyo and Department of Precision Cancer Medicine, Center for Innovative Cancer Treatment, Institute of Science Tokyo Hospital, Tokyo, Japan., Murakami K; Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Shimizu M; Department of Pediatrics, Neonatal and Maternal Medicine, Institute of Science Tokyo, Tokyo, Japan., Komai T; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Kanda H; Department of Allergy and Rheumatology and Immune-Mediated Diseases Therapy Center, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Yasumura J; Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences and Department of Pediatrics, Hiroshima Prefectural Hospital Organization Futabanosato Prefectural Hospital, Hiroshima, Japan., Ando T; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan., Yamasaki Y; Department of Pediatrics, Kagoshima University Hospital, Kagoshima, Japan., Takei S; Department of Pediatrics, Kagoshima University Hospital, Kagoshima, Japan., Ohnishi H; Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu, Japan., Matsubara T; Department of Pediatrics, Dokkyo Medical University Saitama Medical Center, Saitama, Japan., Takizawa T; Department of Pediatrics, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan., Kawai T; Division of Immunology, National Center for Child Health and Development, Tokyo, Japan., Umebayashi H; Department of Rheumatism, Infection Disease, Miyagi Children's Hospital, Sendai, Japan., Nishimata S; Department of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo, Japan., Kawashima H; Department of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo, Japan., Tamura N; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan., Hosokawa J; Department of Applied Genomics, Kazusa DNA Research Institute, Kisarazu, Japan., Kambe N; Department of Dermatology, Graduate School of Medicine, Kyoto University and Center for Allergy, Kyoto University Hospital, Kyoto, Japan., Kitamoto H; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Okabe M; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Yamamoto S; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Kurosawa Y; Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Kaneko U; Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Nakamura Y; Department of Rheumatology, Mie University Graduate School of Medicine and Center for Rheumatic Diseases, Mie University Hospital, Mie, Japan., Miyamoto T; Department of Pediatrics, Tokushima Red Cross Hospital, Tokushima, Japan., Nihira H; Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan, and Department of Pediatrics, Kyoto Okamoto Memorial Hospital, Kuse, Japan., Shibata H; Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan., Tanaka T; Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan, and Department of Pediatrics, Otsu Red Cross Hospital, Otsu, Japan., Hiejima E; Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan., Fujio K; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Nakajima A; Department of Rheumatology, Mie University Graduate School of Medicine and Center for Rheumatic Diseases, Mie University Hospital, Mie, Japan., Yamagishi M; Live Cell Diagnosis, Ltd, Saitama, Japan., Shirasaki Y; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Saito MK; Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan., Okada S; Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan., Ogawa S; Institute for the Advanced Study of Human Biology and Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Takita J; Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan., Ohara O; Department of Applied Genomics, Kazusa DNA Research Institute, Kisarazu, Japan., Nishikomori R; Department of Pediatrics, Kurume University Graduate School of Medicine, Kurume, Japan., Yasumi T; Department of Pediatrics and Japan Environment and Children's Study Kyoto Regional Centre, Kyoto University Graduate School of Medicine, Kyoto, Japan., Izawa K; Department of Pediatrics, Kyoto University Graduate School of Medicine and Center for Allergy, Kyoto University Hospital, Kyoto, Japan.
Source: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2026 Jan; Vol. 78 (1), pp. 231-242. Date of Electronic Publication: 2025 Nov 21.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101623795 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2326-5205 (Electronic) Linking ISSN: 23265191 NLM ISO Abbreviation: Arthritis Rheumatol Subsets: MEDLINE; In Process
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  Data: Longitudinal Analysis of Somatic Mosaicism and Clonal Hematopoiesis in Cryopyrin-Associated Periodic Syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Kato+K%22">Kato K</searchLink>; Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Honda+Y%22">Honda Y</searchLink>; Department of Pediatrics, Graduate School of Medicine, Institute for the Advanced Study of Human Biology, and Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kamatani+T%22">Kamatani T</searchLink>; Department of AI Technology Development, M&D Data Science Center, Institute of Integrated Research, Institute of Science Tokyo and Department of Precision Cancer Medicine, Center for Innovative Cancer Treatment, Institute of Science Tokyo Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Murakami+K%22">Murakami K</searchLink>; Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Shimizu+M%22">Shimizu M</searchLink>; Department of Pediatrics, Neonatal and Maternal Medicine, Institute of Science Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Komai+T%22">Komai T</searchLink>; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kanda+H%22">Kanda H</searchLink>; Department of Allergy and Rheumatology and Immune-Mediated Diseases Therapy Center, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yasumura+J%22">Yasumura J</searchLink>; Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences and Department of Pediatrics, Hiroshima Prefectural Hospital Organization Futabanosato Prefectural Hospital, Hiroshima, Japan.<br /><searchLink fieldCode="AU" term="%22Ando+T%22">Ando T</searchLink>; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yamasaki+Y%22">Yamasaki Y</searchLink>; Department of Pediatrics, Kagoshima University Hospital, Kagoshima, Japan.<br /><searchLink fieldCode="AU" term="%22Takei+S%22">Takei S</searchLink>; Department of Pediatrics, Kagoshima University Hospital, Kagoshima, Japan.<br /><searchLink fieldCode="AU" term="%22Ohnishi+H%22">Ohnishi H</searchLink>; Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu, Japan.<br /><searchLink fieldCode="AU" term="%22Matsubara+T%22">Matsubara T</searchLink>; Department of Pediatrics, Dokkyo Medical University Saitama Medical Center, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Takizawa+T%22">Takizawa T</searchLink>; Department of Pediatrics, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.<br /><searchLink fieldCode="AU" term="%22Kawai+T%22">Kawai T</searchLink>; Division of Immunology, National Center for Child Health and Development, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Umebayashi+H%22">Umebayashi H</searchLink>; Department of Rheumatism, Infection Disease, Miyagi Children's Hospital, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Nishimata+S%22">Nishimata S</searchLink>; Department of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kawashima+H%22">Kawashima H</searchLink>; Department of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tamura+N%22">Tamura N</searchLink>; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hosokawa+J%22">Hosokawa J</searchLink>; Department of Applied Genomics, Kazusa DNA Research Institute, Kisarazu, Japan.<br /><searchLink fieldCode="AU" term="%22Kambe+N%22">Kambe N</searchLink>; Department of Dermatology, Graduate School of Medicine, Kyoto University and Center for Allergy, Kyoto University Hospital, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kitamoto+H%22">Kitamoto H</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Okabe+M%22">Okabe M</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+S%22">Yamamoto S</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kurosawa+Y%22">Kurosawa Y</searchLink>; Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.<br /><searchLink fieldCode="AU" term="%22Kaneko+U%22">Kaneko U</searchLink>; Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.<br /><searchLink fieldCode="AU" term="%22Nakamura+Y%22">Nakamura Y</searchLink>; Department of Rheumatology, Mie University Graduate School of Medicine and Center for Rheumatic Diseases, Mie University Hospital, Mie, Japan.<br /><searchLink fieldCode="AU" term="%22Miyamoto+T%22">Miyamoto T</searchLink>; Department of Pediatrics, Tokushima Red Cross Hospital, Tokushima, Japan.<br /><searchLink fieldCode="AU" term="%22Nihira+H%22">Nihira H</searchLink>; Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan, and Department of Pediatrics, Kyoto Okamoto Memorial Hospital, Kuse, Japan.<br /><searchLink fieldCode="AU" term="%22Shibata+H%22">Shibata H</searchLink>; Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Tanaka+T%22">Tanaka T</searchLink>; Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan, and Department of Pediatrics, Otsu Red Cross Hospital, Otsu, Japan.<br /><searchLink fieldCode="AU" term="%22Hiejima+E%22">Hiejima E</searchLink>; Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Fujio+K%22">Fujio K</searchLink>; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nakajima+A%22">Nakajima A</searchLink>; Department of Rheumatology, Mie University Graduate School of Medicine and Center for Rheumatic Diseases, Mie University Hospital, Mie, Japan.<br /><searchLink fieldCode="AU" term="%22Yamagishi+M%22">Yamagishi M</searchLink>; Live Cell Diagnosis, Ltd, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Shirasaki+Y%22">Shirasaki Y</searchLink>; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Saito+MK%22">Saito MK</searchLink>; Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Okada+S%22">Okada S</searchLink>; Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.<br /><searchLink fieldCode="AU" term="%22Ogawa+S%22">Ogawa S</searchLink>; Institute for the Advanced Study of Human Biology and Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Takita+J%22">Takita J</searchLink>; 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