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CRISPR-Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-Deleted Cancer.

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Title: CRISPR-Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-Deleted Cancer.
Authors: Knoll N; Fralin Biomedical Research Institute, Virginia Tech FBRI Cancer Research Center, Washington, District of Columbia.; Department of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, Virginia.; University of Heidelberg, Heidelberg, Germany., Masser S; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz and BioTechMed-Graz, Graz, Austria., Bordas B; Fralin Biomedical Research Institute, Virginia Tech FBRI Cancer Research Center, Washington, District of Columbia., Ebright RY; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Dana-Farber Cancer Institute, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Li G; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Kesar D; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Destefanis E; Fralin Biomedical Research Institute, Virginia Tech FBRI Cancer Research Center, Washington, District of Columbia., Kania N; Dana-Farber Cancer Institute, Boston, Massachusetts., Rodriguez DJ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Jen J; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Zagar SE; Fralin Biomedical Research Institute, Virginia Tech FBRI Cancer Research Center, Washington, District of Columbia., Mensah C; Fralin Biomedical Research Institute, Virginia Tech FBRI Cancer Research Center, Washington, District of Columbia., Chen Z; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Dana-Farber Cancer Institute, Boston, Massachusetts., Moffitt SJ; Fralin Biomedical Research Institute, Virginia Tech FBRI Cancer Research Center, Washington, District of Columbia., Enakireru EM; Fralin Biomedical Research Institute, Virginia Tech FBRI Cancer Research Center, Washington, District of Columbia.; Erasmus Mundus Joint Masters. University of Calabria, Calabria, Italy., He Y; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Feng B; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Chokshi MK; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Jin CY; Dana-Farber Cancer Institute, Boston, Massachusetts., Raghavan S; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Dana-Farber Cancer Institute, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Sellers WR; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Dana-Farber Cancer Institute, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Mulvaney KM; Fralin Biomedical Research Institute, Virginia Tech FBRI Cancer Research Center, Washington, District of Columbia.; Department of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, Virginia.
Source: Cancer research [Cancer Res] 2025 Sep 15; Vol. 85 (18), pp. 3518-3539.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CRISPR-Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-Deleted Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Knoll+N%22">Knoll N</searchLink>; Fralin Biomedical Research Institute, Virginia Tech FBRI Cancer Research Center, Washington, District of Columbia.; Department of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, Virginia.; University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Masser+S%22">Masser S</searchLink>; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz and BioTechMed-Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Bordas+B%22">Bordas B</searchLink>; Fralin Biomedical Research Institute, Virginia Tech FBRI Cancer Research Center, Washington, District of Columbia.<br /><searchLink fieldCode="AU" term="%22Ebright+RY%22">Ebright RY</searchLink>; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Dana-Farber Cancer Institute, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Kesar+D%22">Kesar D</searchLink>; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Destefanis+E%22">Destefanis E</searchLink>; Fralin Biomedical Research Institute, Virginia Tech FBRI Cancer Research Center, Washington, District of Columbia.<br /><searchLink fieldCode="AU" term="%22Kania+N%22">Kania N</searchLink>; Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Rodriguez+DJ%22">Rodriguez DJ</searchLink>; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Jen+J%22">Jen J</searchLink>; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Zagar+SE%22">Zagar SE</searchLink>; Fralin Biomedical Research Institute, Virginia Tech FBRI Cancer Research Center, Washington, District of Columbia.<br /><searchLink fieldCode="AU" term="%22Mensah+C%22">Mensah C</searchLink>; Fralin Biomedical Research Institute, Virginia Tech FBRI Cancer Research Center, Washington, District of Columbia.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Moffitt+SJ%22">Moffitt SJ</searchLink>; Fralin Biomedical Research Institute, Virginia Tech FBRI Cancer Research Center, Washington, District of Columbia.<br /><searchLink fieldCode="AU" term="%22Enakireru+EM%22">Enakireru EM</searchLink>; Fralin Biomedical Research Institute, Virginia Tech FBRI Cancer Research Center, Washington, District of Columbia.; Erasmus Mundus Joint Masters. University of Calabria, Calabria, Italy.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Feng+B%22">Feng B</searchLink>; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Chokshi+MK%22">Chokshi MK</searchLink>; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Jin+CY%22">Jin CY</searchLink>; Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Raghavan+S%22">Raghavan S</searchLink>; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Dana-Farber Cancer Institute, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Sellers+WR%22">Sellers WR</searchLink>; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Dana-Farber Cancer Institute, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Mulvaney+KM%22">Mulvaney KM</searchLink>; Fralin Biomedical Research Institute, Virginia Tech FBRI Cancer Research Center, Washington, District of Columbia.; Department of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, Virginia.
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