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Cell-type-directed network-correcting combination therapy for Alzheimer's disease.

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Title: Cell-type-directed network-correcting combination therapy for Alzheimer's disease.
Authors: Li Y; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA; Pharmaceutical Science and Pharmacogenomics Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA. Electronic address: yaqiao.li@ucsf.edu., Pereda Serras C; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA; Pharmaceutical Science and Pharmacogenomics Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA., Blumenfeld J; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA., Xie M; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA., Hao Y; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Gladstone Center for Translational Advancement, Gladstone Institutes, San Francisco, CA 94158, USA., Deng E; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA., Chun YY; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA., Holtzman J; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA., An A; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Gladstone Center for Translational Advancement, Gladstone Institutes, San Francisco, CA 94158, USA., Yoon SY; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA., Tang X; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA., Rao A; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA., Woldemariam S; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA., Tang A; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA; Bioengineering Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Bioengineering Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA., Zhang A; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA., Simms J; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA., Lo I; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA., Oskotsky T; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA; Division of Clinical Informatics and Digital Transformation, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA., Keiser MJ; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA; Pharmaceutical Science and Pharmacogenomics Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA., Huang Y; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Gladstone Center for Translational Advancement, Gladstone Institutes, San Francisco, CA 94158, USA; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Departments of Neurology and Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: yadong.huang@gladstone.ucsf.edu., Sirota M; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA; Pharmaceutical Science and Pharmacogenomics Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: marina.sirota@ucsf.edu.
Source: Cell [Cell] 2025 Oct 02; Vol. 188 (20), pp. 5516-5534.e18. Date of Electronic Publication: 2025 Jul 21.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: Cell-type-directed network-correcting combination therapy for Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA; Pharmaceutical Science and Pharmacogenomics Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA. Electronic address: yaqiao.li@ucsf.edu.<br /><searchLink fieldCode="AU" term="%22Pereda+Serras+C%22">Pereda Serras C</searchLink>; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA; Pharmaceutical Science and Pharmacogenomics Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Blumenfeld+J%22">Blumenfeld J</searchLink>; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Xie+M%22">Xie M</searchLink>; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Hao+Y%22">Hao Y</searchLink>; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Gladstone Center for Translational Advancement, Gladstone Institutes, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Deng+E%22">Deng E</searchLink>; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Chun+YY%22">Chun YY</searchLink>; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Holtzman+J%22">Holtzman J</searchLink>; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22An+A%22">An A</searchLink>; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Gladstone Center for Translational Advancement, Gladstone Institutes, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Yoon+SY%22">Yoon SY</searchLink>; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Tang+X%22">Tang X</searchLink>; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Rao+A%22">Rao A</searchLink>; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Woldemariam+S%22">Woldemariam S</searchLink>; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Tang+A%22">Tang A</searchLink>; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA; Bioengineering Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Bioengineering Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+A%22">Zhang A</searchLink>; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Simms+J%22">Simms J</searchLink>; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Lo+I%22">Lo I</searchLink>; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Oskotsky+T%22">Oskotsky T</searchLink>; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA; Division of Clinical Informatics and Digital Transformation, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Keiser+MJ%22">Keiser MJ</searchLink>; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA; Pharmaceutical Science and Pharmacogenomics Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Gladstone Center for Translational Advancement, Gladstone Institutes, San Francisco, CA 94158, USA; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Departments of Neurology and Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: yadong.huang@gladstone.ucsf.edu.<br /><searchLink fieldCode="AU" term="%22Sirota+M%22">Sirota M</searchLink>; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA; Pharmaceutical Science and Pharmacogenomics Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: marina.sirota@ucsf.edu.
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  Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2025 Oct 02; Vol. 188 (20), pp. 5516-5534.e18. <i>Date of Electronic Publication: </i>2025 Jul 21.
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