View in EDS HTML Full Text PDF Full Text

De novo pyrimidine synthesis is a collateral metabolic vulnerability in NF2-deficient mesothelioma.

Saved in:
Bibliographic Details
Title: De novo pyrimidine synthesis is a collateral metabolic vulnerability in NF2-deficient mesothelioma.
Authors: Xu D; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. xuduo@jsph.org.cn., Gao Y; Department of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research (DBMR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Liu S; Department of Cardiothoracic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China., Yin S; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Hu T; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Deng H; Department of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research (DBMR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Zhang T; Department of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research (DBMR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Hegedüs B; Department of Thoracic Surgery, University Medicine Essen - Ruhrlandklinik, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Tüschener Weg 40, 45239, Essen, Germany., Marti TM; Department of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research (DBMR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Dorn P; Department of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research (DBMR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Liang SQ; Department of Medicine, University of Minnesota Twin Cities, 516 Delaware Street SE, Minneapolis, MN, USA., Schmid RA; Department of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research (DBMR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Peng RW; Department of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Renwang.Peng@insel.ch.; Department for BioMedical Research (DBMR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Renwang.Peng@insel.ch., Shu Y; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. shuyongqian@csco.org.cn.
Source: EMBO molecular medicine [EMBO Mol Med] 2025 Sep; Vol. 17 (9), pp. 2258-2298. Date of Electronic Publication: 2025 Jul 24.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40707702
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: De novo pyrimidine synthesis is a collateral metabolic vulnerability in NF2-deficient mesothelioma.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Xu+D%22">Xu D</searchLink>; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. xuduo@jsph.org.cn.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; Department of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research (DBMR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Department of Cardiothoracic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Yin+S%22">Yin S</searchLink>; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Hu+T%22">Hu T</searchLink>; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Deng+H%22">Deng H</searchLink>; Department of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research (DBMR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zhang+T%22">Zhang T</searchLink>; Department of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research (DBMR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hegedüs+B%22">Hegedüs B</searchLink>; Department of Thoracic Surgery, University Medicine Essen - Ruhrlandklinik, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Tüschener Weg 40, 45239, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Marti+TM%22">Marti TM</searchLink>; Department of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research (DBMR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dorn+P%22">Dorn P</searchLink>; Department of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research (DBMR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Liang+SQ%22">Liang SQ</searchLink>; Department of Medicine, University of Minnesota Twin Cities, 516 Delaware Street SE, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Schmid+RA%22">Schmid RA</searchLink>; Department of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research (DBMR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Peng+RW%22">Peng RW</searchLink>; Department of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Renwang.Peng@insel.ch.; Department for BioMedical Research (DBMR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Renwang.Peng@insel.ch.<br /><searchLink fieldCode="AU" term="%22Shu+Y%22">Shu Y</searchLink>; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. shuyongqian@csco.org.cn.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101487380%22">EMBO molecular medicine</searchLink> [EMBO Mol Med] 2025 Sep; Vol. 17 (9), pp. 2258-2298. <i>Date of Electronic Publication: </i>2025 Jul 24.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22EMBO+Press%22">EMBO Press </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101487380 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1757-4684 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217574676%22">17574676 </searchLink><i>NLM ISO Abbreviation: </i>EMBO Mol Med <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40707702
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s44321-025-00278-4
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 2258
    Titles:
      – TitleFull: De novo pyrimidine synthesis is a collateral metabolic vulnerability in NF2-deficient mesothelioma.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Xu D
      – PersonEntity:
          Name:
            NameFull: Gao Y
      – PersonEntity:
          Name:
            NameFull: Liu S
      – PersonEntity:
          Name:
            NameFull: Yin S
      – PersonEntity:
          Name:
            NameFull: Hu T
      – PersonEntity:
          Name:
            NameFull: Deng H
      – PersonEntity:
          Name:
            NameFull: Zhang T
      – PersonEntity:
          Name:
            NameFull: Hegedüs B
      – PersonEntity:
          Name:
            NameFull: Marti TM
      – PersonEntity:
          Name:
            NameFull: Dorn P
      – PersonEntity:
          Name:
            NameFull: Liang SQ
      – PersonEntity:
          Name:
            NameFull: Schmid RA
      – PersonEntity:
          Name:
            NameFull: Peng RW
      – PersonEntity:
          Name:
            NameFull: Shu Y
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 09
              Text: 2025 Sep
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1757-4684
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: EMBO molecular medicine
              Type: main
ResultId 1