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Discovery of Gut-Targeted GPR40 Agonist K-757 and GPR119 Agonist K-833, a Combination Treatment for Metabolic Disorders.

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Title: Discovery of Gut-Targeted GPR40 Agonist K-757 and GPR119 Agonist K-833, a Combination Treatment for Metabolic Disorders.
Authors: Moyes CR; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., He S; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Mathieu S; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Lehman SL; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Francisco MT; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Vardy E; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Terracina G; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Galstian A; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Murphy MJM; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Poterewicz G; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Kosinski D; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Yang X; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Zheng S; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Chan B; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Consolati MJ; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Tschirret-Guth R; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Luzung MR; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Saklatvala R; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Rak G; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Barretto R; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Talaty J; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Vance A; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Zhang H; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Liu J; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Weber AE; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Lauring B; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Pinto S; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States., Sebhat IK; Kallyope, Inc., 430 East 29th Street, 10th Floor, New York, New York 10016, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Aug 14; Vol. 68 (15), pp. 15339-15357. Date of Electronic Publication: 2025 Jul 24.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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