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Variants in DENND2B are associated with vulnerability for neurodevelopmental impairment, psychosis and catatonia.

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Title: Variants in DENND2B are associated with vulnerability for neurodevelopmental impairment, psychosis and catatonia.
Authors: Murthy H; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Hoang N; Department of Genetic Counselling, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada., Stark JC; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada., Cui S; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Pannia E; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Tsoi CT; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Harris S; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada., Ceolin C; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Verhaeghe L; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada., Scholten S; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Baribeau D; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON M4G 1R8, Canada.; Department of Psychiatry, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada., Summers J; Department of Psychiatry, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada., Costain G; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada., Selvanayagam T; Department of Genetic Counselling, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada., Howe JL; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Lewis MES; Department of Medical Genetics, BC Children's Hospital Research Institute, The University of British Columbia, Vancouver, BC V6H 3N1, Canada., Brunet T; Technical University of Munich, School of Medicine, Institute of Human Genetics, Munich 81675, Germany.; Department of Pediatric Neurology and Developmental Medicine and LMU Center for Children with Medical Complexity, Dr von Hauner Children's Hospital, LMU Hospital, Ludwig-Maximilians-University, Munich 80336, Germany., Rieger S; Department of Pediatrics I, University Children's Hospital, Heidelberg, Heidelberg 69120, Germany., Rosenfeld JA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Baylor Genetics Laboratories, Houston, TX 77021, USA., Craigen WJ; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Burrage LC; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Christie MR; Division of Neurology and Rehabilitation, Scottish Rite for Children, Dallas, TX 75219, USA., Baldwin D; Division of Neurology and Rehabilitation, Scottish Rite for Children, Dallas, TX 75219, USA., Wentzensen IM; Clinical Genetics and Genomics, GeneDx, Gaithersburg, MD 20877, USA., Keren B; Département de Génétique médicale, GH Pitié Salpêtrière, APHP, Sorbonne Université, Paris 75013, France., Cogne B; Service de Génétique médicale, Nantes Université, CHU de Nantes, Nantes F-44000/44035, France.; Nantes Université, CHU de Nantes, CNRS, INSERM, l'institut du thorax, Nantes F-44000/44035, France.; Laboratoire de Biologie Médicale Multi-Sites SeqOIA (laboratoire-seqoia.fr), Paris 75014, France., Isidor B; Service de Génétique médicale, Nantes Université, CHU de Nantes, Nantes F-44000/44035, France.; Nantes Université, CHU de Nantes, CNRS, INSERM, l'institut du thorax, Nantes F-44000/44035, France., Afenjar A; Département de génétique et embryologie médicale, Hôpital Armand-Trousseau, Paris 75012, France., Elshafie RM; Ministry of Health, Kuwait Medical Genetics Center, Sulaibikhat 80901, Kuwait., Bastaki L; Ministry of Health, Kuwait Medical Genetics Center, Sulaibikhat 80901, Kuwait., Alkanderi S; Ministry of Health, Kuwait Medical Genetics Center, Sulaibikhat 80901, Kuwait., Myers KA; Department of Child Health and Human Development, Research Institute of the McGill University Health Centre, Montreal, QC H3H 2R9, Canada., Demarest S; Department of Pediatrics and Neurology, School of Medicine, University of Colorado Precision Medicine Institute, Children's Hospital Colorado, Aurora, CO 80045, USA., Angione K; Department of Pediatrics and Neurology, School of Medicine, University of Colorado Precision Medicine Institute, Children's Hospital Colorado, Aurora, CO 80045, USA., Abbott M; Department of Pediatrics and Neurology, School of Medicine, University of Colorado Precision Medicine Institute, Children's Hospital Colorado, Aurora, CO 80045, USA., Campeau PM; Department of Pediatrics, CHU Sainte Justine Research Center, University of Montreal, Montreal, QC H3T 1C5, Canada., Dowling JJ; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Mendoza-Londono R; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Scherer SW; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; McLaughlin Centre and Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada., Deshwar AR; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada.; Department of Paediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada., Vorstman J; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Psychiatry, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.
Source: Brain : a journal of neurology [Brain] 2026 Jan 08; Vol. 149 (1), pp. 252-261.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Variants in DENND2B are associated with vulnerability for neurodevelopmental impairment, psychosis and catatonia.
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  Data: <searchLink fieldCode="AU" term="%22Murthy+H%22">Murthy H</searchLink>; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Hoang+N%22">Hoang N</searchLink>; Department of Genetic Counselling, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada.<br /><searchLink fieldCode="AU" term="%22Stark+JC%22">Stark JC</searchLink>; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada.<br /><searchLink fieldCode="AU" term="%22Cui+S%22">Cui S</searchLink>; 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Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada.<br /><searchLink fieldCode="AU" term="%22Scholten+S%22">Scholten S</searchLink>; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Baribeau+D%22">Baribeau D</searchLink>; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON M4G 1R8, Canada.; Department of Psychiatry, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.<br /><searchLink fieldCode="AU" term="%22Summers+J%22">Summers J</searchLink>; Department of Psychiatry, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; 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            – D: 08
              M: 01
              Text: 2026 Jan 08
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1460-2156
          Numbering:
            – Type: volume
              Value: 149
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Brain : a journal of neurology
              Type: main
ResultId 1