Senescence-associated lysosomal dysfunction impairs cystine deprivation-induced lipid peroxidation and ferroptosis.
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| Title: | Senescence-associated lysosomal dysfunction impairs cystine deprivation-induced lipid peroxidation and ferroptosis. |
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| Authors: | Loo TM; Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan., Zhou X; Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan., Tanaka Y; Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan., Sugawara S; Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan., Yamauchi S; Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan., Kawasaki H; Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan., Matsuoka Y; Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Sugiura Y; Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Sakuma S; Department of Mechanical Engineering, Faculty of Engineering, Kyushu University, Fukuoka, Japan., Yamanishi Y; Department of Mechanical Engineering, Faculty of Engineering, Kyushu University, Fukuoka, Japan., Yotsumoto S; Laboratory of Immune Regulation, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan., Dodo K; Catalysis and Integrated Research Group, RIKEN Center for Sustainable Resource Science, Saitama, Japan., Shirasaki Y; Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo, Japan., Kamatani T; Department of AI Technology Development, Institute of Integrated Research M&D Data Science Center, Institute of Science Tokyo, Tokyo, Japan.; Department of Precision Cancer Medicine, Institute of Science Tokyo Hospital, Tokyo, Japan., Takahashi A; Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan. akiko.takahashi@jfcr.or.jp.; Cancer Cell Communication Project, NEXT-Ganken Program, Japanese Foundation for Cancer Research, Tokyo, Japan. akiko.takahashi@jfcr.or.jp. |
| Source: | Nature communications [Nat Commun] 2025 Jul 29; Vol. 16 (1), pp. 6617. Date of Electronic Publication: 2025 Jul 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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