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NAD(P)+-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite.

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Title: NAD(P)+-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite.
Authors: Wu Q; Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA. Qiangen.Wu@fda.hhs.gov., Fang JL; Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA., Nagumalli SK; Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA., Guo X; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA., Beland FA; Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA.
Source: Archives of toxicology [Arch Toxicol] 2025 Nov; Vol. 99 (11), pp. 4411-4421. Date of Electronic Publication: 2025 Jul 30.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: NAD(P)<superscript>+</superscript>-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite.
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  Data: <searchLink fieldCode="AU" term="%22Wu+Q%22">Wu Q</searchLink>; Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA. Qiangen.Wu@fda.hhs.gov.<br /><searchLink fieldCode="AU" term="%22Fang+JL%22">Fang JL</searchLink>; Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA.<br /><searchLink fieldCode="AU" term="%22Nagumalli+SK%22">Nagumalli SK</searchLink>; Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA.<br /><searchLink fieldCode="AU" term="%22Guo+X%22">Guo X</searchLink>; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA.<br /><searchLink fieldCode="AU" term="%22Beland+FA%22">Beland FA</searchLink>; Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA.
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  Data: <searchLink fieldCode="JN" term="%220417615%22">Archives of toxicology</searchLink> [Arch Toxicol] 2025 Nov; Vol. 99 (11), pp. 4411-4421. <i>Date of Electronic Publication: </i>2025 Jul 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0417615 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0738 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203405761%22">03405761 </searchLink><i>NLM ISO Abbreviation: </i>Arch Toxicol <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00204-025-04140-x
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      – Code: eng
        Text: English
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        StartPage: 4411
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      – TitleFull: NAD(P)+-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite.
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            NameFull: Wu Q
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            NameFull: Fang JL
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              Text: 2025 Nov
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