Thermodynamic Destabilization and Structural Adaptability of 2'-Alkoxy/Fluoro-N3-Methyl Pyrimidine Nucleotides in siRNA Enhance RNA Interference Activity.
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| Title: | Thermodynamic Destabilization and Structural Adaptability of 2'-Alkoxy/Fluoro-N3-Methyl Pyrimidine Nucleotides in siRNA Enhance RNA Interference Activity. |
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| Authors: | Sahoo A; Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India., Gupta S; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India., Das G; Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India., Sharma SN; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India., Ghosh A; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India., Bagale SS; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India., Sinha S; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India., Gore KR; Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2025 Aug 14; Vol. 68 (15), pp. 16371-16394. Date of Electronic Publication: 2025 Jul 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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