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Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer's disease.

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Title: Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer's disease.
Authors: D'Oliveira Albanus R; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63130, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63130, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA., Finan GM; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA., Brase L; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63130, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA., Sweeney N; Department of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH 43210, USA., Kim TY; Department of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH 43210, USA., Chen S; Department of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH 43210, USA., Ryoo Y; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA.; McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Chemistry, Hanyang University, Seoul 04763, Republic of Korea., Park J; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA.; McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA 02114, USA., Guo Q; Department of Biomedical Informatics, Ohio State Comprehensive Cancer Center, Columbus, OH 43210, USA., Iyer AK; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63130, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA., Acquarone M; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63130, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA., You SF; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63130, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA., Novotny BC; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63130, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA., Mace EM; Department of Pediatrics, Columbia University, New York, NY 10032, USA., Ribeiro Pereira PM; Department of Radiology, Division of Radiological Sciences, Washington University School of Medicine, St. Louis, MO 63130, USA., Morris JC; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63130, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63130, USA.; Dominantly Inherited Alzheimer Network (DIAN), Washington University School of Medicine, St. Louis, MO 63130, USA., Holtzman DM; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63130, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63130, USA.; Dominantly Inherited Alzheimer Network (DIAN), Washington University School of Medicine, St. Louis, MO 63130, USA., McDade E; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63130, USA.; Dominantly Inherited Alzheimer Network (DIAN), Washington University School of Medicine, St. Louis, MO 63130, USA., Farlow M; Dominantly Inherited Alzheimer Network (DIAN), Washington University School of Medicine, St. Louis, MO 63130, USA.; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Chhatwal JP; Dominantly Inherited Alzheimer Network (DIAN), Washington University School of Medicine, St. Louis, MO 63130, USA.; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Benitez BA; Department of Neurology, Beth Israel Deaconess, Harvard Medical School, Boston, MA 02215, USA., Piccio L; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63130, USA.; Brain and Mind Centre, School of Medical Sciences, University of Sydney, Camperdown, NSW 2006, Australia., Perrin RJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63130, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63130, USA., Sutherland GT; School of Medical Sciences and Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia., Ma Q; Department of Biomedical Informatics, Ohio State Comprehensive Cancer Center, Columbus, OH 43210, USA., Karch CM; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63130, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA.; Dominantly Inherited Alzheimer Network (DIAN), Washington University School of Medicine, St. Louis, MO 63130, USA., Kim DY; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA.; McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA 02114, USA., Tanzi RE; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA.; McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA 02114, USA., Fu H; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA.; Department of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.; Dominantly Inherited Alzheimer Network (DIAN), Washington University School of Medicine, St. Louis, MO 63130, USA., Harari O; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63130, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA., Kim TW; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Jul 30; Vol. 17 (809), pp. eadx0027. Date of Electronic Publication: 2025 Jul 30.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer's disease.
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Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63130, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA.<br /><searchLink fieldCode="AU" term="%22Mace+EM%22">Mace EM</searchLink>; Department of Pediatrics, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Ribeiro+Pereira+PM%22">Ribeiro Pereira PM</searchLink>; Department of Radiology, Division of Radiological Sciences, Washington University School of Medicine, St. Louis, MO 63130, USA.<br /><searchLink fieldCode="AU" term="%22Morris+JC%22">Morris JC</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63130, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63130, USA.; Dominantly Inherited Alzheimer Network (DIAN), Washington University School of Medicine, St. Louis, MO 63130, USA.<br /><searchLink fieldCode="AU" term="%22Holtzman+DM%22">Holtzman DM</searchLink>; 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Dominantly Inherited Alzheimer Network (DIAN), Washington University School of Medicine, St. Louis, MO 63130, USA.; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Benitez+BA%22">Benitez BA</searchLink>; Department of Neurology, Beth Israel Deaconess, Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Piccio+L%22">Piccio L</searchLink>; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63130, USA.; Brain and Mind Centre, School of Medical Sciences, University of Sydney, Camperdown, NSW 2006, Australia.<br /><searchLink fieldCode="AU" term="%22Perrin+RJ%22">Perrin RJ</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63130, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA.; 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