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Discovery of a novel RSK2 inhibitor for the treatment of metastatic pancreatic cancer.

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Title: Discovery of a novel RSK2 inhibitor for the treatment of metastatic pancreatic cancer.
Authors: Chung CH; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.; Department of Dermatology, School of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan., Hsu KC; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan., Huang MM; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan., Tu HJ; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan., Pan SL; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan., Chao MW; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.; Institute of Biopharmaceutical Sciences, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.; Institute of Precision Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.
Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2538673. Date of Electronic Publication: 2025 Aug 05.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of a novel RSK2 inhibitor for the treatment of metastatic pancreatic cancer.
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  Data: <searchLink fieldCode="AU" term="%22Chung+CH%22">Chung CH</searchLink>; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.; Department of Dermatology, School of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+KC%22">Hsu KC</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+MM%22">Huang MM</searchLink>; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tu+HJ%22">Tu HJ</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Pan+SL%22">Pan SL</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chao+MW%22">Chao MW</searchLink>; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.; Institute of Biopharmaceutical Sciences, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.; Institute of Precision Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101150203%22">Journal of enzyme inhibition and medicinal chemistry</searchLink> [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2538673. <i>Date of Electronic Publication: </i>2025 Aug 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101150203 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1475-6374 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214756366%22">14756366 </searchLink><i>NLM ISO Abbreviation: </i>J Enzyme Inhib Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1080/14756366.2025.2538673
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      – Code: eng
        Text: English
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      – TitleFull: Discovery of a novel RSK2 inhibitor for the treatment of metastatic pancreatic cancer.
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            – D: 01
              M: 12
              Text: 2025 Dec
              Type: published
              Y: 2025
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