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Intracrine FFA4 signaling controls lipolysis at lipid droplets.

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Title: Intracrine FFA4 signaling controls lipolysis at lipid droplets.
Authors: O'Brien SL; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK. s.l.obrien@bham.ac.uk.; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Nottingham and Birmingham, Birmingham, UK. s.l.obrien@bham.ac.uk., Tripp E; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Nottingham and Birmingham, Birmingham, UK., Barki N; Centre for Translational Pharmacology, School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Blondel-Tepaz E; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, Quebec, Canada.; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, Quebec, Canada., Smith G; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Boufersaoui A; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Roberts J; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Pike JA; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Nottingham and Birmingham, Birmingham, UK., Correia J; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Nottingham and Birmingham, Birmingham, UK., Miljus T; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Nottingham and Birmingham, Birmingham, UK., Bouvier M; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, Quebec, Canada.; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, Quebec, Canada., Tennant DA; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Hudson BD; Centre for Translational Pharmacology, School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Gerhart-Hines Z; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Milligan G; Centre for Translational Pharmacology, School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Schwartz TW; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Calebiro D; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK. d.calebiro@bham.ac.uk.; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Nottingham and Birmingham, Birmingham, UK. d.calebiro@bham.ac.uk.; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, UK. d.calebiro@bham.ac.uk.
Source: Nature chemical biology [Nat Chem Biol] 2026 Jan; Vol. 22 (1), pp. 109-119. Date of Electronic Publication: 2025 Aug 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22O'Brien+SL%22">O'Brien SL</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK. s.l.obrien@bham.ac.uk.; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Nottingham and Birmingham, Birmingham, UK. s.l.obrien@bham.ac.uk.<br /><searchLink fieldCode="AU" term="%22Tripp+E%22">Tripp E</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Nottingham and Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Barki+N%22">Barki N</searchLink>; Centre for Translational Pharmacology, School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Blondel-Tepaz+E%22">Blondel-Tepaz E</searchLink>; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, Quebec, Canada.; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Smith+G%22">Smith G</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Boufersaoui+A%22">Boufersaoui A</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+J%22">Roberts J</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Pike+JA%22">Pike JA</searchLink>; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Nottingham and Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Correia+J%22">Correia J</searchLink>; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Nottingham and Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Miljus+T%22">Miljus T</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Nottingham and Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Bouvier+M%22">Bouvier M</searchLink>; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, Quebec, Canada.; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Tennant+DA%22">Tennant DA</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Hudson+BD%22">Hudson BD</searchLink>; Centre for Translational Pharmacology, School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Gerhart-Hines+Z%22">Gerhart-Hines Z</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Milligan+G%22">Milligan G</searchLink>; Centre for Translational Pharmacology, School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Schwartz+TW%22">Schwartz TW</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Calebiro+D%22">Calebiro D</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK. d.calebiro@bham.ac.uk.; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Nottingham and Birmingham, Birmingham, UK. d.calebiro@bham.ac.uk.; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, UK. d.calebiro@bham.ac.uk.
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