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Reaching the therapeutic ceiling in IBD: Can Advanced Combination Treatment (ACT) offer a solution?

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Title: Reaching the therapeutic ceiling in IBD: Can Advanced Combination Treatment (ACT) offer a solution?
Authors: Solitano V; Division of Gastroenterology and Gastrointestinal Endoscopy, IRCCS Ospedale San Raffaele, Università Vita-Salute San Raffaele, Milan, Italy; Division of Gastroenterology, Department of Medicine, Western University Schulich School of Medicine, London, Ontario, Canada; Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada., Hanžel J; Medical Faculty, University of Ljubljana, Department of Gastroenterology, UMC Ljubljana, Ljubljana, Slovenia., Estevinho MM; Department of Gastroenterology, Unidade Local de Saúde Gaia Espinho (ULSGE), Vila Nova de Gaia, Portugal; Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal., Sedano R; Division of Gastroenterology, Department of Medicine, Western University Schulich School of Medicine, London, Ontario, Canada., Massimino L; Division of Gastroenterology and Gastrointestinal Endoscopy, IRCCS Ospedale San Raffaele, Università Vita-Salute San Raffaele, Milan, Italy., Ungaro F; Division of Gastroenterology and Gastrointestinal Endoscopy, IRCCS Ospedale San Raffaele, Università Vita-Salute San Raffaele, Milan, Italy., Jairath V; Division of Gastroenterology, Department of Medicine, Western University Schulich School of Medicine, London, Ontario, Canada; Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada. Electronic address: vjairath@uwo.ca.
Source: Best practice & research. Clinical gastroenterology [Best Pract Res Clin Gastroenterol] 2025 Aug; Vol. 77, pp. 101981. Date of Electronic Publication: 2025 Jan 08.
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101120605 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1916 (Electronic) Linking ISSN: 15216918 NLM ISO Abbreviation: Best Pract Res Clin Gastroenterol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Reaching the therapeutic ceiling in IBD: Can Advanced Combination Treatment (ACT) offer a solution?
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  Data: <searchLink fieldCode="AU" term="%22Solitano+V%22">Solitano V</searchLink>; Division of Gastroenterology and Gastrointestinal Endoscopy, IRCCS Ospedale San Raffaele, Università Vita-Salute San Raffaele, Milan, Italy; Division of Gastroenterology, Department of Medicine, Western University Schulich School of Medicine, London, Ontario, Canada; Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Hanžel+J%22">Hanžel J</searchLink>; Medical Faculty, University of Ljubljana, Department of Gastroenterology, UMC Ljubljana, Ljubljana, Slovenia.<br /><searchLink fieldCode="AU" term="%22Estevinho+MM%22">Estevinho MM</searchLink>; Department of Gastroenterology, Unidade Local de Saúde Gaia Espinho (ULSGE), Vila Nova de Gaia, Portugal; Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Sedano+R%22">Sedano R</searchLink>; Division of Gastroenterology, Department of Medicine, Western University Schulich School of Medicine, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Massimino+L%22">Massimino L</searchLink>; Division of Gastroenterology and Gastrointestinal Endoscopy, IRCCS Ospedale San Raffaele, Università Vita-Salute San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ungaro+F%22">Ungaro F</searchLink>; Division of Gastroenterology and Gastrointestinal Endoscopy, IRCCS Ospedale San Raffaele, Università Vita-Salute San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Jairath+V%22">Jairath V</searchLink>; Division of Gastroenterology, Department of Medicine, Western University Schulich School of Medicine, London, Ontario, Canada; Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada. Electronic address: vjairath@uwo.ca.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101120605 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-1916 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215216918%22">15216918 </searchLink><i>NLM ISO Abbreviation: </i>Best Pract Res Clin Gastroenterol <i>Subsets: </i>MEDLINE
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              Text: 2025 Aug
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