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LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome.

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Title: LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome.
Authors: Maloney MT; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Wang X; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.; Tenvie Therapeutics, South San Francisco, CA, 94080, USA., Ghosh R; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Andrews SV; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Maciuca R; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Masoud ST; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Agam M; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.; Tenvie Therapeutics, South San Francisco, CA, 94080, USA., Caprioli RM; Mass Spectrometry Research Center, Vanderbilt University, 9160 MRB III, 465 21 Avenue South, Nashville, TN, 37240, USA., Astarita G; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Bondar VV; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Chen J; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Chiu CL; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Davis SS; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Ho AC; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Nguyen HN; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Propson NE; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Reyzer ML; Mass Spectrometry Research Center, Vanderbilt University, 9160 MRB III, 465 21 Avenue South, Nashville, TN, 37240, USA., Davis OB; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Deen MC; Department of Chemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada., Zhu S; Department of Chemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada., Di Paolo G; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Vocadlo DJ; Department of Chemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada., Estrada AA; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.; Tenvie Therapeutics, South San Francisco, CA, 94080, USA., de Vicente J; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.; Tenvie Therapeutics, South San Francisco, CA, 94080, USA., Lewcock JW; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Arguello A; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Suh JH; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Huntwork-Rodriguez S; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA., Henry AG; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA. henry@dnli.com.
Source: Molecular neurodegeneration [Mol Neurodegener] 2025 Aug 06; Vol. 20 (1), pp. 89. Date of Electronic Publication: 2025 Aug 06.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome.
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  Data: <searchLink fieldCode="AU" term="%22Maloney+MT%22">Maloney MT</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.; Tenvie Therapeutics, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Ghosh+R%22">Ghosh R</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Andrews+SV%22">Andrews SV</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Maciuca+R%22">Maciuca R</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Masoud+ST%22">Masoud ST</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Agam+M%22">Agam M</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.; Tenvie Therapeutics, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Caprioli+RM%22">Caprioli RM</searchLink>; Mass Spectrometry Research Center, Vanderbilt University, 9160 MRB III, 465 21 Avenue South, Nashville, TN, 37240, USA.<br /><searchLink fieldCode="AU" term="%22Astarita+G%22">Astarita G</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Bondar+VV%22">Bondar VV</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Chiu+CL%22">Chiu CL</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Davis+SS%22">Davis SS</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Ho+AC%22">Ho AC</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+HN%22">Nguyen HN</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Propson+NE%22">Propson NE</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Reyzer+ML%22">Reyzer ML</searchLink>; Mass Spectrometry Research Center, Vanderbilt University, 9160 MRB III, 465 21 Avenue South, Nashville, TN, 37240, USA.<br /><searchLink fieldCode="AU" term="%22Davis+OB%22">Davis OB</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Deen+MC%22">Deen MC</searchLink>; Department of Chemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.<br /><searchLink fieldCode="AU" term="%22Zhu+S%22">Zhu S</searchLink>; Department of Chemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.<br /><searchLink fieldCode="AU" term="%22Di+Paolo+G%22">Di Paolo G</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Vocadlo+DJ%22">Vocadlo DJ</searchLink>; Department of Chemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.<br /><searchLink fieldCode="AU" term="%22Estrada+AA%22">Estrada AA</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.; Tenvie Therapeutics, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22de+Vicente+J%22">de Vicente J</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.; Tenvie Therapeutics, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Lewcock+JW%22">Lewcock JW</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Arguello+A%22">Arguello A</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Suh+JH%22">Suh JH</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Huntwork-Rodriguez+S%22">Huntwork-Rodriguez S</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Henry+AG%22">Henry AG</searchLink>; Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA, 94080, USA. henry@dnli.com.
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  Data: <searchLink fieldCode="JN" term="%22101266600%22">Molecular neurodegeneration</searchLink> [Mol Neurodegener] 2025 Aug 06; Vol. 20 (1), pp. 89. <i>Date of Electronic Publication: </i>2025 Aug 06.
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