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Mesenteric Versus Conventional Approach During Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma (MAPLE-PD trial): A Multicenter Randomized Controlled Trial.

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Title: Mesenteric Versus Conventional Approach During Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma (MAPLE-PD trial): A Multicenter Randomized Controlled Trial.
Authors: Hirono S; Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.; Department of Gastroenterological Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Hyogo Medical University, Nishinomiya, Hyogo, Japan., Kitahata Y; Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan., Motobayashi H; Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan., Satoi S; Department of Pancreatobiliary Surgery, Kansai Medical University, Hirakata, Osaka, Japan., Sho M; Department of Surgery, Nara Medical University, Kashihara, Nara, Japan., Takami H; Department of Gastroenterological Surgery, Nagoya University, Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan., Kamei K; Department of Surgery, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan., Shibuya K; Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan., Hidaka M; Department of Digestive and General Surgery, Shimane University Faculty of Medicine, Izumo, Shimane, Japan., Uemura K; Department of Surgery, Institute of Biomedical and Health Science, Hiroshima University, Minami-ku, Hiroshima, Japan., Kimura K; Department of Hepato-Biliary-Pancreatic Surgery Graduate School of Medicine, Osaka Metropolitan University, Abeno-ku, Osaka, Japan., Mataki Y; Department of Digestive surgery, Kagoshima University, Kagoshima city, Kagoshima, Japan., Nagakawa Y; Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan., Hayashi H; Department of Gastroenterology, Kumamoto University, Honjo, Kumamoto, Japan., Morimura R; Department of Digestive Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Nakamura M; Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan., Wan K; School of Medicine, Wakayama Medical University, Clinical Study Support Center, Wakayama, Japan., Shimokawa T; School of Medicine, Wakayama Medical University, Clinical Study Support Center, Wakayama, Japan., Nakao A; Department of Gastroenterological Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Japan., Yamaue H; Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.; Department of Surgery, Division of Gastroenterological and General Surgery, School of Medicine, Showa Medical University, Shinagawa-Ku, Tokyo, Japan.
Corporate Authors: MAPLE-PD trial investigators
Source: Annals of surgery [Ann Surg] 2026 Apr 01; Vol. 283 (4), pp. 581-592. Date of Electronic Publication: 2025 Aug 07.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Comparative Study
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0372354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1140 (Electronic) Linking ISSN: 00034932 NLM ISO Abbreviation: Ann Surg Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Mesenteric Versus Conventional Approach During Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma (MAPLE-PD trial): A Multicenter Randomized Controlled Trial.
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  Data: <searchLink fieldCode="AU" term="%22Hirono+S%22">Hirono S</searchLink>; Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.; Department of Gastroenterological Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Hyogo Medical University, Nishinomiya, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Kitahata+Y%22">Kitahata Y</searchLink>; Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.<br /><searchLink fieldCode="AU" term="%22Motobayashi+H%22">Motobayashi H</searchLink>; Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.<br /><searchLink fieldCode="AU" term="%22Satoi+S%22">Satoi S</searchLink>; Department of Pancreatobiliary Surgery, Kansai Medical University, Hirakata, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Sho+M%22">Sho M</searchLink>; Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.<br /><searchLink fieldCode="AU" term="%22Takami+H%22">Takami H</searchLink>; Department of Gastroenterological Surgery, Nagoya University, Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Kamei+K%22">Kamei K</searchLink>; Department of Surgery, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Shibuya+K%22">Shibuya K</searchLink>; Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.<br /><searchLink fieldCode="AU" term="%22Hidaka+M%22">Hidaka M</searchLink>; Department of Digestive and General Surgery, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.<br /><searchLink fieldCode="AU" term="%22Uemura+K%22">Uemura K</searchLink>; Department of Surgery, Institute of Biomedical and Health Science, Hiroshima University, Minami-ku, Hiroshima, Japan.<br /><searchLink fieldCode="AU" term="%22Kimura+K%22">Kimura K</searchLink>; Department of Hepato-Biliary-Pancreatic Surgery Graduate School of Medicine, Osaka Metropolitan University, Abeno-ku, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Mataki+Y%22">Mataki Y</searchLink>; Department of Digestive surgery, Kagoshima University, Kagoshima city, Kagoshima, Japan.<br /><searchLink fieldCode="AU" term="%22Nagakawa+Y%22">Nagakawa Y</searchLink>; Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hayashi+H%22">Hayashi H</searchLink>; Department of Gastroenterology, Kumamoto University, Honjo, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Morimura+R%22">Morimura R</searchLink>; Department of Digestive Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Nakamura+M%22">Nakamura M</searchLink>; Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Wan+K%22">Wan K</searchLink>; School of Medicine, Wakayama Medical University, Clinical Study Support Center, Wakayama, Japan.<br /><searchLink fieldCode="AU" term="%22Shimokawa+T%22">Shimokawa T</searchLink>; School of Medicine, Wakayama Medical University, Clinical Study Support Center, Wakayama, Japan.<br /><searchLink fieldCode="AU" term="%22Nakao+A%22">Nakao A</searchLink>; Department of Gastroenterological Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Yamaue+H%22">Yamaue H</searchLink>; Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.; Department of Surgery, Division of Gastroenterological and General Surgery, School of Medicine, Showa Medical University, Shinagawa-Ku, Tokyo, Japan.
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  Data: <searchLink fieldCode="JN" term="%220372354%22">Annals of surgery</searchLink> [Ann Surg] 2026 Apr 01; Vol. 283 (4), pp. 581-592. <i>Date of Electronic Publication: </i>2025 Aug 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lippincott+Williams+%26+Wilkins%22">Lippincott Williams & Wilkins </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372354 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1528-1140 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200034932%22">00034932 </searchLink><i>NLM ISO Abbreviation: </i>Ann Surg <i>Subsets: </i>MEDLINE
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              Text: 2026 Apr 01
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