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Evaluating cannabidiol-induced liver injury with and without valproate using a three-dimensional human hepatocyte spheroid model.

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Title: Evaluating cannabidiol-induced liver injury with and without valproate using a three-dimensional human hepatocyte spheroid model.
Authors: Beers JL; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; Department of Pharmaceutics, University of Washington School of Pharmacy, Seattle, WA, United States of America., Harvey SL; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America., Lanphier RM; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America., Rushing BR; Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, United States of America., McRitchie SL; Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, United States of America., Sumner SJ; Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, United States of America., Jackson KD; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America. Electronic address: klarissa.jackson@unc.edu.
Source: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2025 Dec; Vol. 109, pp. 106126. Date of Electronic Publication: 2025 Aug 05.
Publication Type: Journal Article
Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 8712158 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3177 (Electronic) Linking ISSN: 08872333 NLM ISO Abbreviation: Toxicol In Vitro Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Beers+JL%22">Beers JL</searchLink>; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; Department of Pharmaceutics, University of Washington School of Pharmacy, Seattle, WA, United States of America.<br /><searchLink fieldCode="AU" term="%22Harvey+SL%22">Harvey SL</searchLink>; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.<br /><searchLink fieldCode="AU" term="%22Lanphier+RM%22">Lanphier RM</searchLink>; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.<br /><searchLink fieldCode="AU" term="%22Rushing+BR%22">Rushing BR</searchLink>; Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, United States of America.<br /><searchLink fieldCode="AU" term="%22McRitchie+SL%22">McRitchie SL</searchLink>; Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, United States of America.<br /><searchLink fieldCode="AU" term="%22Sumner+SJ%22">Sumner SJ</searchLink>; Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, United States of America.<br /><searchLink fieldCode="AU" term="%22Jackson+KD%22">Jackson KD</searchLink>; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America. Electronic address: klarissa.jackson@unc.edu.
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