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Uncovering hidden enhancers through unbiased in vivo testing.

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Title: Uncovering hidden enhancers through unbiased in vivo testing.
Authors: Mannion BJ; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA.; Comparative Biochemistry Program, University of California, Berkeley, CA, USA., Tran S; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Plajzer-Frick I; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Novak CS; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Afzal V; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Akiyama JA; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Sospedra-Arrufat I; Centro Andaluz de Biología del Desarrollo, Consejo Superior de Investigaciones Científicas, Universidad Pablo de Olavide, and Junta de Andalucía, Seville, Spain., Barton S; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Beckman E; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Garvin TH; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Godfrey P; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Godoy J; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Hunter RD; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Kato M; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Kosicki M; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Kronshage AN; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Lee EA; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Meky EM; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Pham QT; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., von Maydell K; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Zhu Y; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA., Lopez-Rios J; Centro Andaluz de Biología del Desarrollo, Consejo Superior de Investigaciones Científicas, Universidad Pablo de Olavide, and Junta de Andalucía, Seville, Spain.; Universidad Loyola Andalucía, School of Health Sciences, Seville Campus, 41704, Dos Hermanas, Seville, Spain., Dickel DE; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA.; Octant, Inc., Emeryville, CA, USA., Osterwalder M; Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland. marco.osterwalder@unibe.ch.; Department of Cardiology, Bern University Hospital, Bern, Switzerland. marco.osterwalder@unibe.ch., Visel A; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA. AVisel@lbl.gov.; U.S. Department of Energy Joint Genome Institute, 1 Cyclotron Road, Berkeley, CA, USA. AVisel@lbl.gov.; School of Natural Sciences, University of California, Merced, Merced, California, USA. AVisel@lbl.gov., Pennacchio LA; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA. LAPennacchio@lbl.gov.; Comparative Biochemistry Program, University of California, Berkeley, CA, USA. LAPennacchio@lbl.gov.; U.S. Department of Energy Joint Genome Institute, 1 Cyclotron Road, Berkeley, CA, USA. LAPennacchio@lbl.gov.
Source: Nature communications [Nat Commun] 2025 Aug 08; Vol. 16 (1), pp. 7313. Date of Electronic Publication: 2025 Aug 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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AVisel@lbl.gov.; U.S. Department of Energy Joint Genome Institute, 1 Cyclotron Road, Berkeley, CA, USA. AVisel@lbl.gov.; School of Natural Sciences, University of California, Merced, Merced, California, USA. AVisel@lbl.gov.<br /><searchLink fieldCode="AU" term="%22Pennacchio+LA%22">Pennacchio LA</searchLink>; Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, USA. LAPennacchio@lbl.gov.; Comparative Biochemistry Program, University of California, Berkeley, CA, USA. LAPennacchio@lbl.gov.; U.S. Department of Energy Joint Genome Institute, 1 Cyclotron Road, Berkeley, CA, USA. LAPennacchio@lbl.gov.
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