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Implementing a context-augmented large language model to guide precision cancer medicine.

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Title: Implementing a context-augmented large language model to guide precision cancer medicine.
Authors: Jun H; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Tanaka Y; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Johri S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Harvard Medical School, Boston, MA 02115, USA., Carvalho FL; Department of Urology, Brigham and Women's Hospital, Boston, MA 02115, USA., Jordan AC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Labaki C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Nagy M; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Boston Children's Hospital, Boston, MA 02115, USA., O'Meara TA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Pappa T; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Brigham and Women's Hospital, Boston, MA 02115, USA., Pimenta EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Saad E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Yang DD; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA 02115, USA., Gillani R; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.; Boston Children's Hospital, Boston, MA 02115, USA., Tewari AK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Harvard Medical School, Boston, MA 02115, USA.; Brigham and Women's Hospital, Boston, MA 02115, USA., Reardon B; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Van Allen E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Harvard Medical School, Boston, MA 02115, USA.; Lead contact.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Jul 24. Date of Electronic Publication: 2025 Jul 24.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: <searchLink fieldCode="AU" term="%22Jun+H%22">Jun H</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Tanaka+Y%22">Tanaka Y</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Johri+S%22">Johri S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Carvalho+FL%22">Carvalho FL</searchLink>; Department of Urology, Brigham and Women's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Jordan+AC%22">Jordan AC</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Labaki+C%22">Labaki C</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Nagy+M%22">Nagy M</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22O'Meara+TA%22">O'Meara TA</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Pappa+T%22">Pappa T</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Brigham and Women's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Pimenta+EM%22">Pimenta EM</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Saad+E%22">Saad E</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Yang+DD%22">Yang DD</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Gillani+R%22">Gillani R</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.; Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Tewari+AK%22">Tewari AK</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Harvard Medical School, Boston, MA 02115, USA.; Brigham and Women's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Reardon+B%22">Reardon B</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Van+Allen+E%22">Van Allen E</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Harvard Medical School, Boston, MA 02115, USA.; Lead contact.
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        Value: 10.1101/2025.05.09.25327312
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        Text: English
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