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Dual Immune Check Point Blockade in MGMT-Unmethylated Newly Diagnosed Glioblastoma: NRG Oncology BN007, a Randomized Phase II/III Clinical Trial.

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Title: Dual Immune Check Point Blockade in MGMT-Unmethylated Newly Diagnosed Glioblastoma: NRG Oncology BN007, a Randomized Phase II/III Clinical Trial.
Authors: Lassman AB; Division of Neuro-Oncology, Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY.; Herbert Irving Comprehensive Cancer Center, New York, NY.; NewYork-Presbyterian, New York, NY., Polley MC; NRG Oncology Statistics and Data Management Center, Philadelphia, PA.; Department of Public Health Sciences, University of Chicago, Chicago, IL., Iwamoto FM; Division of Neuro-Oncology, Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY.; Herbert Irving Comprehensive Cancer Center, New York, NY.; NewYork-Presbyterian, New York, NY., Sloan AE; Department of Neurosurgical Oncology, Piedmont Health, Atlanta, GA., Wang TJC; Herbert Irving Comprehensive Cancer Center, New York, NY.; NewYork-Presbyterian, New York, NY.; Deptartment of Radiation Oncology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY., Aldape KD; Laboratory of Pathology, National Cancer Institute, Bethesda, MD., Wefel JS; Department of Neuro-Oncology, Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX., Gondi V; Department of Radiation Oncology, Northwestern Medicine Cancer Center Warrenville and Proton Center, Warrenville, IL., Gutierrez AN; Department of Radiation Oncology, Miami Cancer Institute-Baptist Health South Florida, Miami, FL., Manasawala MH; Department of Radiology, WellSpan Health, York, PA., Gilbert MR; National Institutes of Health Clinical Center, Neuro-Oncology Branch, Bethesda, MD., Sulman EP; Department of Radiation Oncology, New York University (NYU) Grossman School of Medicine, New York, NY.; Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY., Wolchok JD; NewYork-Presbyterian, New York, NY.; Department of Medical Oncology, Meyer Cancer Center, Weill Cornell Medicine, New York, NY., Green RM; Department of Neurology, Kaiser Permanente-Los Angeles Medical Center, Los Angeles, CA.; Accrual for Kaiser Permanente NCI Community Oncology Research Program., Neil EC; Department of Neurology, University of Minnesota/M Health Fairview Cancer Center, Minneapolis, MN.; Accruals for Metro Minnesota Community Oncology Research Consortium., Lukas RV; Department of Neurology, Northwestern University, Chicago, IL., Goldlust SA; Department of Neuro-Oncology, Saint Luke's Hospital, Saint Luke's Cancer Institute, Kansas City, MO.; Accruals for Hackensack University Medical Center., Snuderl M; Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY.; Department of Pathology, New York University (NYU) Grossman School of Medicine, New York, NY., Galbraith K; Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY.; Department of Pathology, University of Washington, Seattle, WA., Dignam JJ; NRG Oncology Statistics and Data Management Center, Philadelphia, PA.; Department of Public Health Sciences, University of Chicago, Chicago, IL., Won M; NRG Oncology Statistics and Data Management Center, Philadelphia, PA.; Statistics Department, American College of Radiology, Philadelphia, PA., Mehta MP; Department of Radiation Oncology, Miami Cancer Institute-Baptist Health South Florida, Miami, FL.
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2025 Sep 20; Vol. 43 (27), pp. 3032-3040. Date of Electronic Publication: 2025 Aug 08.
Publication Type: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dual Immune Check Point Blockade in MGMT-Unmethylated Newly Diagnosed Glioblastoma: NRG Oncology BN007, a Randomized Phase II/III Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Lassman+AB%22">Lassman AB</searchLink>; Division of Neuro-Oncology, Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY.; Herbert Irving Comprehensive Cancer Center, New York, NY.; NewYork-Presbyterian, New York, NY.<br /><searchLink fieldCode="AU" term="%22Polley+MC%22">Polley MC</searchLink>; NRG Oncology Statistics and Data Management Center, Philadelphia, PA.; Department of Public Health Sciences, University of Chicago, Chicago, IL.<br /><searchLink fieldCode="AU" term="%22Iwamoto+FM%22">Iwamoto FM</searchLink>; Division of Neuro-Oncology, Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY.; Herbert Irving Comprehensive Cancer Center, New York, NY.; NewYork-Presbyterian, New York, NY.<br /><searchLink fieldCode="AU" term="%22Sloan+AE%22">Sloan AE</searchLink>; Department of Neurosurgical Oncology, Piedmont Health, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Wang+TJC%22">Wang TJC</searchLink>; Herbert Irving Comprehensive Cancer Center, New York, NY.; NewYork-Presbyterian, New York, NY.; Deptartment of Radiation Oncology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY.<br /><searchLink fieldCode="AU" term="%22Aldape+KD%22">Aldape KD</searchLink>; Laboratory of Pathology, National Cancer Institute, Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22Wefel+JS%22">Wefel JS</searchLink>; Department of Neuro-Oncology, Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Gondi+V%22">Gondi V</searchLink>; Department of Radiation Oncology, Northwestern Medicine Cancer Center Warrenville and Proton Center, Warrenville, IL.<br /><searchLink fieldCode="AU" term="%22Gutierrez+AN%22">Gutierrez AN</searchLink>; Department of Radiation Oncology, Miami Cancer Institute-Baptist Health South Florida, Miami, FL.<br /><searchLink fieldCode="AU" term="%22Manasawala+MH%22">Manasawala MH</searchLink>; Department of Radiology, WellSpan Health, York, PA.<br /><searchLink fieldCode="AU" term="%22Gilbert+MR%22">Gilbert MR</searchLink>; National Institutes of Health Clinical Center, Neuro-Oncology Branch, Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22Sulman+EP%22">Sulman EP</searchLink>; Department of Radiation Oncology, New York University (NYU) Grossman School of Medicine, New York, NY.; Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY.<br /><searchLink fieldCode="AU" term="%22Wolchok+JD%22">Wolchok JD</searchLink>; NewYork-Presbyterian, New York, NY.; Department of Medical Oncology, Meyer Cancer Center, Weill Cornell Medicine, New York, NY.<br /><searchLink fieldCode="AU" term="%22Green+RM%22">Green RM</searchLink>; Department of Neurology, Kaiser Permanente-Los Angeles Medical Center, Los Angeles, CA.; Accrual for Kaiser Permanente NCI Community Oncology Research Program.<br /><searchLink fieldCode="AU" term="%22Neil+EC%22">Neil EC</searchLink>; Department of Neurology, University of Minnesota/M Health Fairview Cancer Center, Minneapolis, MN.; Accruals for Metro Minnesota Community Oncology Research Consortium.<br /><searchLink fieldCode="AU" term="%22Lukas+RV%22">Lukas RV</searchLink>; Department of Neurology, Northwestern University, Chicago, IL.<br /><searchLink fieldCode="AU" term="%22Goldlust+SA%22">Goldlust SA</searchLink>; Department of Neuro-Oncology, Saint Luke's Hospital, Saint Luke's Cancer Institute, Kansas City, MO.; Accruals for Hackensack University Medical Center.<br /><searchLink fieldCode="AU" term="%22Snuderl+M%22">Snuderl M</searchLink>; Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY.; Department of Pathology, New York University (NYU) Grossman School of Medicine, New York, NY.<br /><searchLink fieldCode="AU" term="%22Galbraith+K%22">Galbraith K</searchLink>; Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY.; Department of Pathology, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Dignam+JJ%22">Dignam JJ</searchLink>; NRG Oncology Statistics and Data Management Center, Philadelphia, PA.; Department of Public Health Sciences, University of Chicago, Chicago, IL.<br /><searchLink fieldCode="AU" term="%22Won+M%22">Won M</searchLink>; NRG Oncology Statistics and Data Management Center, Philadelphia, PA.; Statistics Department, American College of Radiology, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Mehta+MP%22">Mehta MP</searchLink>; Department of Radiation Oncology, Miami Cancer Institute-Baptist Health South Florida, Miami, FL.
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  Data: <searchLink fieldCode="JN" term="%228309333%22">Journal of clinical oncology : official journal of the American Society of Clinical Oncology</searchLink> [J Clin Oncol] 2025 Sep 20; Vol. 43 (27), pp. 3032-3040. <i>Date of Electronic Publication: </i>2025 Aug 08.
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  Data: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
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