Ascending single-dose study of the safety, pharmacokinetics, and pharmacodynamics of CSTI-500, a novel monoamine triple reuptake inhibitor, first-in-human.
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| Title: | Ascending single-dose study of the safety, pharmacokinetics, and pharmacodynamics of CSTI-500, a novel monoamine triple reuptake inhibitor, first-in-human. |
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| Authors: | Appel L; Molecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden. lieuwe.appel@akademiska.se.; PET Centre, Department of Medical Imaging, Uppsala University Hospital, 75185, Uppsala, Sweden. lieuwe.appel@akademiska.se., Risinger R; BioXcel Therapeutics Inc., 555 Long Wharf Drive, New Haven, CT, 06511, USA., Wall A; Molecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.; PET Centre, Department of Medical Imaging, Uppsala University Hospital, 75185, Uppsala, Sweden., Murck H; Philipps-University Marburg, Marburg, Germany.; Murck-Neuroscience LLC Westfield, Westfield, NJ, USA., Liu S; ConSynance Therapeutics, Inc., 11 University Place, Rensselaer, NY, 12144, USA., Antoni G; PET Centre, Department of Medical Imaging, Uppsala University Hospital, 75185, Uppsala, Sweden.; Department of Medical Chemistry, Uppsala University, Uppsala, Sweden., Lane R; Ionis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, CA, 92010, USA. |
| Source: | Psychopharmacology [Psychopharmacology (Berl)] 2026 Mar; Vol. 243 (3), pp. 565-580. Date of Electronic Publication: 2025 Aug 11. |
| Publication Type: | Journal Article; Randomized Controlled Trial |
| Journal Info: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40784919 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Ascending single-dose study of the safety, pharmacokinetics, and pharmacodynamics of CSTI-500, a novel monoamine triple reuptake inhibitor, first-in-human. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Appel+L%22">Appel L</searchLink>; Molecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden. lieuwe.appel@akademiska.se.; PET Centre, Department of Medical Imaging, Uppsala University Hospital, 75185, Uppsala, Sweden. lieuwe.appel@akademiska.se.<br /><searchLink fieldCode="AU" term="%22Risinger+R%22">Risinger R</searchLink>; BioXcel Therapeutics Inc., 555 Long Wharf Drive, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Wall+A%22">Wall A</searchLink>; Molecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.; PET Centre, Department of Medical Imaging, Uppsala University Hospital, 75185, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Murck+H%22">Murck H</searchLink>; Philipps-University Marburg, Marburg, Germany.; Murck-Neuroscience LLC Westfield, Westfield, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; ConSynance Therapeutics, Inc., 11 University Place, Rensselaer, NY, 12144, USA.<br /><searchLink fieldCode="AU" term="%22Antoni+G%22">Antoni G</searchLink>; PET Centre, Department of Medical Imaging, Uppsala University Hospital, 75185, Uppsala, Sweden.; Department of Medical Chemistry, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Lane+R%22">Lane R</searchLink>; Ionis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, CA, 92010, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227608025%22">Psychopharmacology</searchLink> [Psychopharmacology (Berl)] 2026 Mar; Vol. 243 (3), pp. 565-580. <i>Date of Electronic Publication: </i>2025 Aug 11. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>7608025 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-2072 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200333158%22">00333158 </searchLink><i>NLM ISO Abbreviation: </i>Psychopharmacology (Berl) <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40784919 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-025-06861-4 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 565 Titles: – TitleFull: Ascending single-dose study of the safety, pharmacokinetics, and pharmacodynamics of CSTI-500, a novel monoamine triple reuptake inhibitor, first-in-human. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Appel L – PersonEntity: Name: NameFull: Risinger R – PersonEntity: Name: NameFull: Wall A – PersonEntity: Name: NameFull: Murck H – PersonEntity: Name: NameFull: Liu S – PersonEntity: Name: NameFull: Antoni G – PersonEntity: Name: NameFull: Lane R IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 2026 Mar Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1432-2072 Numbering: – Type: volume Value: 243 – Type: issue Value: 3 Titles: – TitleFull: Psychopharmacology Type: main |
| ResultId | 1 |
