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NADPH acts as an endogenous P2X7 receptor modulator to gate neuroinflammatory responses of microglia.

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Title: NADPH acts as an endogenous P2X7 receptor modulator to gate neuroinflammatory responses of microglia.
Authors: Mou YJ; Department of Anesthesiology, the First Affiliated Hospital of Soochow University, Suzhou, 215006, China.; Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.; Institute of Anesthesiology, Soochow University, Suzhou, 215006, China., Li FM; Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China., Lou JT; Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China., Tu HY; Institutes for Translational Medicine, Suzhou Medical College of Soochow University, Suzhou, 215123, China., Zhu Y; Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.; Department of Pharmacology, School of Medicine, Northwest University, Xi-an, 710069, China., Sheng R; Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China., Zhang ZL; Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150081, China., Zhao YZ; Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China., Ji FH; Department of Anesthesiology, the First Affiliated Hospital of Soochow University, Suzhou, 215006, China.; Institute of Anesthesiology, Soochow University, Suzhou, 215006, China., Wu JC; Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. wujunchao@suda.edu.cn., Qin ZH; Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. qinzhenhong@suda.edu.cn.; Institute of Health Science and Technology, Suzhou Gaobo Vocational College, Suzhou, 215163, China. qinzhenhong@suda.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jan; Vol. 47 (1), pp. 69-85. Date of Electronic Publication: 2025 Aug 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: NADPH acts as an endogenous P2X7 receptor modulator to gate neuroinflammatory responses of microglia.
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  Data: <searchLink fieldCode="AU" term="%22Mou+YJ%22">Mou YJ</searchLink>; Department of Anesthesiology, the First Affiliated Hospital of Soochow University, Suzhou, 215006, China.; Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.; Institute of Anesthesiology, Soochow University, Suzhou, 215006, China.<br /><searchLink fieldCode="AU" term="%22Li+FM%22">Li FM</searchLink>; Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Lou+JT%22">Lou JT</searchLink>; Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Tu+HY%22">Tu HY</searchLink>; Institutes for Translational Medicine, Suzhou Medical College of Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.; Department of Pharmacology, School of Medicine, Northwest University, Xi-an, 710069, China.<br /><searchLink fieldCode="AU" term="%22Sheng+R%22">Sheng R</searchLink>; Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Zhang+ZL%22">Zhang ZL</searchLink>; Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.<br /><searchLink fieldCode="AU" term="%22Zhao+YZ%22">Zhao YZ</searchLink>; Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.<br /><searchLink fieldCode="AU" term="%22Ji+FH%22">Ji FH</searchLink>; Department of Anesthesiology, the First Affiliated Hospital of Soochow University, Suzhou, 215006, China.; Institute of Anesthesiology, Soochow University, Suzhou, 215006, China.<br /><searchLink fieldCode="AU" term="%22Wu+JC%22">Wu JC</searchLink>; Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. wujunchao@suda.edu.cn.<br /><searchLink fieldCode="AU" term="%22Qin+ZH%22">Qin ZH</searchLink>; Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. qinzhenhong@suda.edu.cn.; Institute of Health Science and Technology, Suzhou Gaobo Vocational College, Suzhou, 215163, China. qinzhenhong@suda.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2026 Jan; Vol. 47 (1), pp. 69-85. <i>Date of Electronic Publication: </i>2025 Aug 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100956087 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-7254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216714083%22">16714083 </searchLink><i>NLM ISO Abbreviation: </i>Acta Pharmacol Sin <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41401-025-01638-z
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              Text: 2026 Jan
              Type: published
              Y: 2026
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