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Challenging CDKN2A assessment in BRAF-altered gliomas: lessons from a pleomorphic xanthoastrocytoma-enriched cohort.

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Title: Challenging CDKN2A assessment in BRAF-altered gliomas: lessons from a pleomorphic xanthoastrocytoma-enriched cohort.
Authors: Wolf T; Pathology Department, University Hospitals of Strasbourg, 67098, Strasbourg, France. thibaut.wolf@chru-strasbourg.fr., Reita D; Laboratory of Biochemistry and Molecular Biology, Department of Cancer Molecular Genetics, University Hospitals of Strasbourg, 67200, Strasbourg, France.; Laboratory Bioimaging and Pathologies, UMR CNRS 7021, OnKO3T Team, Faculty of Pharmacy, 67401, Illkirch, France., Deschuyter M; Laboratory Bioimaging and Pathologies, UMR CNRS 7021, OnKO3T Team, Faculty of Pharmacy, 67401, Illkirch, France.; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, University Hospitals of Strasbourg, Lille, Nancy, Strasbourg, France., Salmanli C; Laboratory Bioimaging and Pathologies, UMR CNRS 7021, OnKO3T Team, Faculty of Pharmacy, 67401, Illkirch, France.; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, University Hospitals of Strasbourg, Lille, Nancy, Strasbourg, France., Buffa J; Laboratory of Biochemistry and Molecular Biology, Department of Cancer Molecular Genetics, University Hospitals of Strasbourg, 67200, Strasbourg, France., Pencreach E; Laboratory of Biochemistry and Molecular Biology, Department of Cancer Molecular Genetics, University Hospitals of Strasbourg, 67200, Strasbourg, France., Guérin E; Laboratory of Biochemistry and Molecular Biology, Department of Cancer Molecular Genetics, University Hospitals of Strasbourg, 67200, Strasbourg, France., Jeandidier E; Cytogenetic Department, Hospital of Mulhouse, 68100, Mulhouse, France., Miguet M; Cytogenetic Department, Hospital of Mulhouse, 68100, Mulhouse, France., Chenard MP; Pathology Department, University Hospitals of Strasbourg, 67098, Strasbourg, France.; Centre de Ressources Biologiques, University Hospitals of Strasbourg, 67098, Strasbourg, France., Geyer L; Pathology Department, University Hospitals of Strasbourg, 67098, Strasbourg, France., Noel G; Radiotherapy Department, Institut de Cancérologie Strasbourg Europe, 67098, Strasbourg, France., Todeschi J; Neurosurgery Department, University Hospitals of Strasbourg, 67098, Strasbourg, France., Gauchotte G; Department of Biopathology, University Hospitals of Nancy, 54500, Vandœuvre-lès-Nancy, France., Martin S; Laboratory Bioimaging and Pathologies, UMR CNRS 7021, OnKO3T Team, Faculty of Pharmacy, 67401, Illkirch, France.; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, University Hospitals of Strasbourg, Lille, Nancy, Strasbourg, France., Entz-Werlé N; Laboratory Bioimaging and Pathologies, UMR CNRS 7021, OnKO3T Team, Faculty of Pharmacy, 67401, Illkirch, France.; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, University Hospitals of Strasbourg, Lille, Nancy, Strasbourg, France.; Pediatric Oncology Department, University Hospitals of Strasbourg, 67098, Strasbourg, France., Lhermitte B; Pathology Department, University Hospitals of Strasbourg, 67098, Strasbourg, France. benoit.lhermitte@chru-strasbourg.fr.; Laboratory Bioimaging and Pathologies, UMR CNRS 7021, OnKO3T Team, Faculty of Pharmacy, 67401, Illkirch, France. benoit.lhermitte@chru-strasbourg.fr.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2025 Aug 11; Vol. 13 (1), pp. 170. Date of Electronic Publication: 2025 Aug 11.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
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  Data: Challenging CDKN2A assessment in BRAF-altered gliomas: lessons from a pleomorphic xanthoastrocytoma-enriched cohort.
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  Data: <searchLink fieldCode="AU" term="%22Wolf+T%22">Wolf T</searchLink>; Pathology Department, University Hospitals of Strasbourg, 67098, Strasbourg, France. thibaut.wolf@chru-strasbourg.fr.<br /><searchLink fieldCode="AU" term="%22Reita+D%22">Reita D</searchLink>; Laboratory of Biochemistry and Molecular Biology, Department of Cancer Molecular Genetics, University Hospitals of Strasbourg, 67200, Strasbourg, France.; Laboratory Bioimaging and Pathologies, UMR CNRS 7021, OnKO3T Team, Faculty of Pharmacy, 67401, Illkirch, France.<br /><searchLink fieldCode="AU" term="%22Deschuyter+M%22">Deschuyter M</searchLink>; Laboratory Bioimaging and Pathologies, UMR CNRS 7021, OnKO3T Team, Faculty of Pharmacy, 67401, Illkirch, France.; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, University Hospitals of Strasbourg, Lille, Nancy, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Salmanli+C%22">Salmanli C</searchLink>; Laboratory Bioimaging and Pathologies, UMR CNRS 7021, OnKO3T Team, Faculty of Pharmacy, 67401, Illkirch, France.; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, University Hospitals of Strasbourg, Lille, Nancy, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Buffa+J%22">Buffa J</searchLink>; Laboratory of Biochemistry and Molecular Biology, Department of Cancer Molecular Genetics, University Hospitals of Strasbourg, 67200, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Pencreach+E%22">Pencreach E</searchLink>; Laboratory of Biochemistry and Molecular Biology, Department of Cancer Molecular Genetics, University Hospitals of Strasbourg, 67200, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Guérin+E%22">Guérin E</searchLink>; Laboratory of Biochemistry and Molecular Biology, Department of Cancer Molecular Genetics, University Hospitals of Strasbourg, 67200, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Jeandidier+E%22">Jeandidier E</searchLink>; Cytogenetic Department, Hospital of Mulhouse, 68100, Mulhouse, France.<br /><searchLink fieldCode="AU" term="%22Miguet+M%22">Miguet M</searchLink>; Cytogenetic Department, Hospital of Mulhouse, 68100, Mulhouse, France.<br /><searchLink fieldCode="AU" term="%22Chenard+MP%22">Chenard MP</searchLink>; Pathology Department, University Hospitals of Strasbourg, 67098, Strasbourg, France.; Centre de Ressources Biologiques, University Hospitals of Strasbourg, 67098, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Geyer+L%22">Geyer L</searchLink>; Pathology Department, University Hospitals of Strasbourg, 67098, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Noel+G%22">Noel G</searchLink>; Radiotherapy Department, Institut de Cancérologie Strasbourg Europe, 67098, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Todeschi+J%22">Todeschi J</searchLink>; Neurosurgery Department, University Hospitals of Strasbourg, 67098, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Gauchotte+G%22">Gauchotte G</searchLink>; Department of Biopathology, University Hospitals of Nancy, 54500, Vandœuvre-lès-Nancy, France.<br /><searchLink fieldCode="AU" term="%22Martin+S%22">Martin S</searchLink>; Laboratory Bioimaging and Pathologies, UMR CNRS 7021, OnKO3T Team, Faculty of Pharmacy, 67401, Illkirch, France.; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, University Hospitals of Strasbourg, Lille, Nancy, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Entz-Werlé+N%22">Entz-Werlé N</searchLink>; Laboratory Bioimaging and Pathologies, UMR CNRS 7021, OnKO3T Team, Faculty of Pharmacy, 67401, Illkirch, France.; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, University Hospitals of Strasbourg, Lille, Nancy, Strasbourg, France.; Pediatric Oncology Department, University Hospitals of Strasbourg, 67098, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Lhermitte+B%22">Lhermitte B</searchLink>; Pathology Department, University Hospitals of Strasbourg, 67098, Strasbourg, France. benoit.lhermitte@chru-strasbourg.fr.; Laboratory Bioimaging and Pathologies, UMR CNRS 7021, OnKO3T Team, Faculty of Pharmacy, 67401, Illkirch, France. benoit.lhermitte@chru-strasbourg.fr.
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