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Titin-related familial dilated cardiomyopathy: factors associated with disease onset.

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Title: Titin-related familial dilated cardiomyopathy: factors associated with disease onset.
Authors: Johnson R; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, 405 Liverpool St, Darlinghurst, NSW 2010, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia., Fletcher RA; The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Peters S; Department of Cardiology, Royal Melbourne Hospital, Melbourne, VIC, Australia., Ohanian M; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, 405 Liverpool St, Darlinghurst, NSW 2010, Australia., Soka M; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, 405 Liverpool St, Darlinghurst, NSW 2010, Australia., Smolnikov A; School of Biotechnology and Biomolecular Sciences, Faculty of Science, UNSW Sydney, Sydney, NSW, Australia., Abihider KE; Division of Clinical Genetics, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Ackerman MJ; Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Windland Smith Rice Genetic Heart Rhythm Clinic, Mayo Clinic, Rochester, MN, USA.; Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN, USA., Ader F; Department of Cardiogenetic and Myogenetic Molecular and Cellular, Metabolic Biochemistry, AP-HP Sorbonne Université, Pitié Salpêtrière Hospital, Paris, France., Akhtar MM; Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, London, UK.; Cardiology Department, Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Amin AS; Department of Clinical Cardiology, Heart Center, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands., Ashley EA; Department of Medicine, Stanford University, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA., Atherton JJ; Department of Cardiology, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia., Austin R; Genetic Health Queensland Service, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.; Australian Genomics, Melbourne, VIC, Australia., Baas AF; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands., Bagnall RD; Bioinformatics and Molecular Genetics Group, Centenary Institute, University of Sydney, Sydney, NSW, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., Ross SB; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia., Blouin JL; Department of Diagnostics, Service of Genetic Medicine, University Hospitals of Geneva, Geneva, Switzerland., Brown EE; Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Bundgaard H; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Cannie D; Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, London, UK.; Department of Inherited Cardiovascular Diseases, Barts Heart Centre, St Bartholomew's Hospital, London, UK., Chmielewski P; Unit for Screening Studies in Inherited Cardiovascular Diseases, National Institute of Cardiology, Warsaw, Poland., Correnti G; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, Australia., Crespo-Leiro MG; Heart Failure and Heart Transplant Unit, Complexo Hospitalario Universitario a Coruña, Centro de Investigación Biomédica en Red (CIBERCV), Instituto de Investigación Biomédica de A Coruña (INIBIC), Universidade da Coruña, La Coruña, Spain., Dal Ferro M; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiothoracovascular, Azienda Sanitaria Universitaria Integrata, Trieste, Italy.; Department of Medicine, University of Trieste, Trieste, Italy., Dellefave-Castillo LM; Center for Genetic Medicine, Northwestern University, Evanston, IL, USA.; Center for Genetic Medicine, Bluhm Cardiovascular Institute, Chicago, IL, USA., Dominguez F; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Hospital Universitario Puerta de Hierro, Instituto Investigación Sanitaria Puerta de Hierro-Segovia de Arana, CIBERCV, Madrid, Spain., Dooijes D; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands., Dybro AM; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark., Ed Demri Y; Cardiology Department, AP-HP, Cochin Hospital, Paris, France., El Hachmi M; Département de Génétique, AP-HP, Hôpital Européen Georges Pompidou, Service de Médecine Génomique des Maladies Rares, Paris, France.; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Escobar-Lopez L; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Hospital Universitario Puerta de Hierro, Instituto Investigación Sanitaria Puerta de Hierro-Segovia de Arana, CIBERCV, Madrid, Spain., Foye SJ; Team Titin, Inc . Pine Brook, NJ, USA., Franaszczyk M; Department of Medical Biology, National Institute of Cardiology, Warsaw, Poland.; Department of Medical Genetics, Warsaw Medical University, Warsaw, Poland., Gigli M; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiothoracovascular, Azienda Sanitaria Universitaria Integrata, Trieste, Italy.; Department of Medicine, University of Trieste, Trieste, Italy., Lopez EG; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Hospital Universitario Puerta de Hierro, Instituto Investigación Sanitaria Puerta de Hierro-Segovia de Arana, CIBERCV, Madrid, Spain., Goudal A; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Service de Genetique Medicale, Centre Hospitalier Universitaire de Nantes, Nantes, France., Graw S; Cardiovascular Institute and Adult Medical Genetics Program, University of Colorado, Cardiovascular Institute, Aurora, CO, USA., Guipponi M; Department of Diagnostics, Service of Genetic Medicine, University Hospitals of Geneva, Geneva, Switzerland., Haan E; Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia., Haas J; Department of Cardiology, Pneumology and Angiology, Heidelberg University Hospital, Heidelberg, Germany.; Informatics for Life, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany., Hammersley DJ; Cardiology Department, Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.; National Heart and Lung Institute, Imperial College, London, UK., Hansen FG; Department of Cardiology, Odense University Hospital, Odense, Denmark., Hayward CS; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Heart Transplantation Division, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia.; Cardiology Department, St Vincent's Hospital Sydney, 390 Victoria St, Darlinghurst, NSW 2010, Australia., Hey TM; Department of Cardiology, Odense University Hospital, Odense, Denmark., Heymans S; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.; Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands., Ho CY; Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA., Houweling AC; Department of Human Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Ingles J; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Genomics and Inherited Disease Program, Garvan Institute of Medical Research, Sydney, NSW, Australia., Ingrey A; Hunter Genetics, Hunter New England Local Health District, Newcastle, NSW, Australia., Jabbour A; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Heart Transplantation Division, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia.; Cardiology Department, St Vincent's Hospital Sydney, 390 Victoria St, Darlinghurst, NSW 2010, Australia., James PA; Genomic Medicine, Royal Melbourne Hospital, Melbourne, VIC, Australia.; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia., Jansweijer JA; Department of Clinical and Experimental Cardiology, Amsterdam University Medical Centre, Amsterdam, The Netherlands.; Department of Cardiology, Haga Teaching Hospital, The Hague, The Netherlands., Jongbloed JDH; Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands., Keogh AM; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Heart Transplantation Division, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia.; Cardiology Department, St Vincent's Hospital Sydney, 390 Victoria St, Darlinghurst, NSW 2010, Australia., Larrañaga-Moreira JM; Unidad de Cardiopatías Familiares, INIBIC, Complexo Hospitalario Universitario de A Coruña, Servizo Galego de Saúde, Universidade da Coruña, A Coruña, Spain., Lekanne Deprez RH; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Human Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Macciocca I; Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Melbourne, VIC, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia., Macdonald PS; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Heart Transplantation Division, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia.; Cardiology Department, St Vincent's Hospital Sydney, 390 Victoria St, Darlinghurst, NSW 2010, Australia., Mansencal N; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Emergency Medicine, AP-HP, Hôpital Ambroise Paré, Boulogne-Billancourt, France., Mansour J; Tasmanian Clinical Genetics Service and Tasmanian Health Service, Hobart, TAS, Australia., Martinez-Veira C; Unidad de Cardiopatías Familiares, CIBERCV, Madrid, Spain., McDonough B; Department of Genetics, Harvard Medical School, Boston, MA, USA., McGaughran J; Genetic Health Queensland Service, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.; School of Medicine, The University of Queensland, Brisbane, QLD, Australia., Medo K; Cardiovascular Institute and Adult Medical Genetics Program, University of Colorado, Cardiovascular Institute, Aurora, CO, USA., Merlo M; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiothoracovascular, Azienda Sanitaria Universitaria Integrata, Trieste, Italy.; Department of Medicine, University of Trieste, Trieste, Italy., Michalak E; Unit for Screening Studies in Inherited Cardiovascular Diseases, National Institute of Cardiology, Warsaw, Poland., Monserrat L; Department of Cardiology, Health in Code, A Coruña, Spain., Mountain H; Genetic Services of Western Australia, Perth, WA, Australia.; Genetic Counselling Department, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia., Muller SA; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands., Murphy AM; Division of Pediatric Cardiology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Murray B; Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Oates EC; School of Biotechnology and Biomolecular Sciences, Faculty of Science, UNSW Sydney, Sydney, NSW, Australia.; Department of Neurology, Sydney Children's Hospital, Sydney, NSW, Australia., Ormondroyd E; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK., Pachter N; Genetic Services of Western Australia, Perth, WA, Australia.; Genetic Services Department, King Edward Memorial Hospital, Perth, WA, Australia.; School of Medicine, University of Western Australia, Perth, WA, Australia., Paldino A; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiothoracovascular, Azienda Sanitaria Universitaria Integrata, Trieste, Italy.; Department of Medicine, University of Trieste, Trieste, Italy., Palmyre A; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Genetics and Referral Center for Hereditary Cardiac Diseases, AP-HP, Hôpital Ambroise Paré, Boulogne-Billancourt, France., Pereira NL; Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Windland Smith Rice Genetic Heart Rhythm Clinic, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN, USA., Picard KC; Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA., Poplawski N; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.; Discipline of Paediatrics, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia., Prasad S; National Heart and Lung Institute, Imperial College, London, UK., Proukhnitzky J; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Genetics and Cardiology Department, Sorbonne Université, AP-HP, INSERM UMRS_1166, IHU-ICAN, Hôpital Pitié-Salpêtrière, Paris, France., Pruny JF; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Sorbonne Université, Centre de Référence pour les Maladies Cardiaques Héréditaires ou rares, AP-HP, INSERM UMRS_1166, IHU-ICAN, Hôpital Pitié-Salpêtrière, Paris, France., Reant P; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Service de Cardiologie, Centre Hospitalier Universitaire de Bordeaux, Université de Bordeaux, CIC 1401, Bordeaux, France.; French Reference Center in Inherited Cardiomyopathies, ERN GUARD-Heart, Bordeaux, France., Richard P; Department of Cardiogenetic and Myogenetic Molecular and Cellular, Metabolic Biochemistry, AP-HP Sorbonne Université, Pitié Salpêtrière Hospital, Paris, France., Ronan A; Genetics Unit, Newcastle Medical Genetics, Newcastle, NSW, Australia.; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, Australia., Sedaghat-Hamedani F; Department of Cardiology, Pneumology and Angiology, Heidelberg University Hospital, Heidelberg, Germany.; Informatics for Life, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany., Semsarian C; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Agnes Ginges Centre for Molecular Cardiology, Centenary Institute, University of Sydney, Sydney, NSW, Australia.; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia., Storm G; Cardiovascular Institute and Adult Medical Genetics Program, University of Colorado, Cardiovascular Institute, Aurora, CO, USA., Stroeks S; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands.; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands., Syrris P; Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, London, UK., Taylor MRG; Cardiovascular Institute and Adult Medical Genetics Program, University of Colorado, Cardiovascular Institute, Aurora, CO, USA., Thomson K; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford Regional Genetics Laboratories, Churchill Hospital, Oxford, UK., Thompson T; Genomic Medicine, Royal Melbourne Hospital, Melbourne, VIC, Australia.; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia., van Tintelen JP; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands., Vissing CR; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Cardiology Department, Hvidovre Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Waddell-Smith KE; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, Australia., Wallis M; Tasmanian Clinical Genetics Service and Tasmanian Health Service, Hobart, TAS, Australia.; School of Medicine and Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia., Zentner D; Department of Cardiology, Royal Melbourne Hospital, Melbourne, VIC, Australia.; Genomic Medicine, Royal Melbourne Hospital, Melbourne, VIC, Australia.; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia., Arnott C; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.; Cardiovascular Program, The George Institute for Global Health, UNSW Sydney, Sydney, NSW, Australia., Marian AJ; Center for Cardiovascular Genetic Research, Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, USA., Oh J; Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea., Fokstuen S; Department of Diagnostics, Service of Genetic Medicine, University Hospitals of Geneva, Geneva, Switzerland., James CA; Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Barriales-Villa R; Inherited Cardiovascular Disease Unit, Complexo Hospitalario Universitario A Coruña, A Coruña, Galicia, Spain., Meder B; Department of Cardiology, Pneumology and Angiology, Heidelberg University Hospital, Heidelberg, Germany.; Informatics for Life, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany., Wahbi K; Cardiology Department, AP-HP, Cochin Hospital, Paris, France.; Faculté de Médecine, Université Paris-Cité, Paris, France., Giudicessi JR; Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Windland Smith Rice Genetic Heart Rhythm Clinic, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN, USA., Parikh VN; Department of Medicine, Stanford Center for Inherited Cardiovascular Disease, Stanford, CA, USA., Ware JS; Cardiology Department, Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.; Cardiovascular and Genomic Medicine, National Heart and Lung Institute and MRC London Institute of Medical Sciences, Imperial College London, London, UK., Piriou N; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Centre de Référence Cardiomyopathies, L'institut du Thorax, Nantes Université, Nantes, France., Rooryck C; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Service de Génétique Médicale, CHU Bordeaux, Bordeaux, France.; Maladies Rares: Génétique et Métabolisme, Université de Bordeaux, INSERMU1211, Bordeaux, France., Lakdawala NK; Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Mestroni L; Cardiovascular Institute and Adult Medical Genetics Program, University of Colorado, Cardiovascular Institute, Aurora, CO, USA., Sinagra G; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiothoracovascular, Azienda Sanitaria Universitaria Integrata, Trieste, Italy.; Department of Medicine, University of Trieste, Trieste, Italy., Elliott PM; Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, London, UK.; Department of Inherited Cardiovascular Diseases, Barts Heart Centre, St Bartholomew's Hospital, London, UK., Watkins H; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., McNally EM; Center for Genetic Medicine, Northwestern University, Evanston, IL, USA.; Center for Genetic Medicine, Bluhm Cardiovascular Institute, Chicago, IL, USA., Charron P; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Genetics and Referral Center for Hereditary Cardiac Diseases, AP-HP, Hôpital Ambroise Paré, Boulogne-Billancourt, France.; Sorbonne Université, Centre de Référence pour les Maladies Cardiaques Héréditaires ou rares, AP-HP, INSERM UMRS_1166, IHU-ICAN, Hôpital Pitié-Salpêtrière, Paris, France., van Spaendonck-Zwarts KY; Genetic Health Queensland Service, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.; Department of Human Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands., Garcia-Pavia P; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Hospital Universitario Puerta de Hierro, Instituto Investigación Sanitaria Puerta de Hierro-Segovia de Arana, CIBERCV, Madrid, Spain.; Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain., Peña-Peña ML; Department of Cardiology, Virgen del Rocio University Hospital, Seville, Spain., Mogensen J; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark., Christensen AH; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Bilińska ZT; Unit for Screening Studies in Inherited Cardiovascular Diseases, National Institute of Cardiology, Warsaw, Poland., Rasmussen TB; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark., Seidman JG; Department of Genetics, Harvard Medical School, Boston, MA, USA., Seidman CE; Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Te Riele ASJM; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands., Verdonschot JAJ; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands.; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands., Pinto YM; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Clinical Cardiology and Experimental Cardiology, University of Amsterdam, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Christiaans I; Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands., Fatkin D; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, 405 Liverpool St, Darlinghurst, NSW 2010, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Cardiology Department, St Vincent's Hospital Sydney, 390 Victoria St, Darlinghurst, NSW 2010, Australia.
Corporate Authors: Australian Genomics Cardiac Flagship
Source: European heart journal [Eur Heart J] 2025 Dec 22; Vol. 46 (48), pp. 5240-5257.
Publication Type: Journal Article; Multicenter Study; Observational Study
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 8006263 Publication Model: Print Cited Medium: Internet ISSN: 1522-9645 (Electronic) Linking ISSN: 0195668X NLM ISO Abbreviation: Eur Heart J Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Titin-related familial dilated cardiomyopathy: factors associated with disease onset.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Johnson+R%22">Johnson R</searchLink>; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, 405 Liverpool St, Darlinghurst, NSW 2010, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Fletcher+RA%22">Fletcher RA</searchLink>; The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Peters+S%22">Peters S</searchLink>; Department of Cardiology, Royal Melbourne Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Ohanian+M%22">Ohanian M</searchLink>; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, 405 Liverpool St, Darlinghurst, NSW 2010, Australia.<br /><searchLink fieldCode="AU" term="%22Soka+M%22">Soka M</searchLink>; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, 405 Liverpool St, Darlinghurst, NSW 2010, Australia.<br /><searchLink fieldCode="AU" term="%22Smolnikov+A%22">Smolnikov A</searchLink>; School of Biotechnology and Biomolecular Sciences, Faculty of Science, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Abihider+KE%22">Abihider KE</searchLink>; Division of Clinical Genetics, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Ackerman+MJ%22">Ackerman MJ</searchLink>; Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Windland Smith Rice Genetic Heart Rhythm Clinic, Mayo Clinic, Rochester, MN, USA.; Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Ader+F%22">Ader F</searchLink>; Department of Cardiogenetic and Myogenetic Molecular and Cellular, Metabolic Biochemistry, AP-HP Sorbonne Université, Pitié Salpêtrière Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Akhtar+MM%22">Akhtar MM</searchLink>; Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, London, UK.; Cardiology Department, Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Amin+AS%22">Amin AS</searchLink>; Department of Clinical Cardiology, Heart Center, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ashley+EA%22">Ashley EA</searchLink>; Department of Medicine, Stanford University, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Atherton+JJ%22">Atherton JJ</searchLink>; Department of Cardiology, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Austin+R%22">Austin R</searchLink>; Genetic Health Queensland Service, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.; Australian Genomics, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Baas+AF%22">Baas AF</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bagnall+RD%22">Bagnall RD</searchLink>; Bioinformatics and Molecular Genetics Group, Centenary Institute, University of Sydney, Sydney, NSW, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Ross+SB%22">Ross SB</searchLink>; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Blouin+JL%22">Blouin JL</searchLink>; Department of Diagnostics, Service of Genetic Medicine, University Hospitals of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Brown+EE%22">Brown EE</searchLink>; Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Bundgaard+H%22">Bundgaard H</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Cannie+D%22">Cannie D</searchLink>; Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, London, UK.; Department of Inherited Cardiovascular Diseases, Barts Heart Centre, St Bartholomew's Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Chmielewski+P%22">Chmielewski P</searchLink>; Unit for Screening Studies in Inherited Cardiovascular Diseases, National Institute of Cardiology, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Correnti+G%22">Correnti G</searchLink>; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Crespo-Leiro+MG%22">Crespo-Leiro MG</searchLink>; Heart Failure and Heart Transplant Unit, Complexo Hospitalario Universitario a Coruña, Centro de Investigación Biomédica en Red (CIBERCV), Instituto de Investigación Biomédica de A Coruña (INIBIC), Universidade da Coruña, La Coruña, Spain.<br /><searchLink fieldCode="AU" term="%22Dal+Ferro+M%22">Dal Ferro M</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiothoracovascular, Azienda Sanitaria Universitaria Integrata, Trieste, Italy.; Department of Medicine, University of Trieste, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Dellefave-Castillo+LM%22">Dellefave-Castillo LM</searchLink>; Center for Genetic Medicine, Northwestern University, Evanston, IL, USA.; Center for Genetic Medicine, Bluhm Cardiovascular Institute, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Dominguez+F%22">Dominguez F</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Hospital Universitario Puerta de Hierro, Instituto Investigación Sanitaria Puerta de Hierro-Segovia de Arana, CIBERCV, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Dooijes+D%22">Dooijes D</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Dybro+AM%22">Dybro AM</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Ed+Demri+Y%22">Ed Demri Y</searchLink>; Cardiology Department, AP-HP, Cochin Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22El+Hachmi+M%22">El Hachmi M</searchLink>; Département de Génétique, AP-HP, Hôpital Européen Georges Pompidou, Service de Médecine Génomique des Maladies Rares, Paris, France.; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Escobar-Lopez+L%22">Escobar-Lopez L</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Hospital Universitario Puerta de Hierro, Instituto Investigación Sanitaria Puerta de Hierro-Segovia de Arana, CIBERCV, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Foye+SJ%22">Foye SJ</searchLink>; Team Titin, Inc . Pine Brook, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Franaszczyk+M%22">Franaszczyk M</searchLink>; Department of Medical Biology, National Institute of Cardiology, Warsaw, Poland.; Department of Medical Genetics, Warsaw Medical University, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Gigli+M%22">Gigli M</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiothoracovascular, Azienda Sanitaria Universitaria Integrata, Trieste, Italy.; Department of Medicine, University of Trieste, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Lopez+EG%22">Lopez EG</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Hospital Universitario Puerta de Hierro, Instituto Investigación Sanitaria Puerta de Hierro-Segovia de Arana, CIBERCV, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Goudal+A%22">Goudal A</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Service de Genetique Medicale, Centre Hospitalier Universitaire de Nantes, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Graw+S%22">Graw S</searchLink>; Cardiovascular Institute and Adult Medical Genetics Program, University of Colorado, Cardiovascular Institute, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Guipponi+M%22">Guipponi M</searchLink>; Department of Diagnostics, Service of Genetic Medicine, University Hospitals of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Haan+E%22">Haan E</searchLink>; Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Haas+J%22">Haas J</searchLink>; Department of Cardiology, Pneumology and Angiology, Heidelberg University Hospital, Heidelberg, Germany.; Informatics for Life, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hammersley+DJ%22">Hammersley DJ</searchLink>; Cardiology Department, Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.; National Heart and Lung Institute, Imperial College, London, UK.<br /><searchLink fieldCode="AU" term="%22Hansen+FG%22">Hansen FG</searchLink>; Department of Cardiology, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Hayward+CS%22">Hayward CS</searchLink>; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Heart Transplantation Division, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia.; Cardiology Department, St Vincent's Hospital Sydney, 390 Victoria St, Darlinghurst, NSW 2010, Australia.<br /><searchLink fieldCode="AU" term="%22Hey+TM%22">Hey TM</searchLink>; Department of Cardiology, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Heymans+S%22">Heymans S</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.; Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ho+CY%22">Ho CY</searchLink>; Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Houweling+AC%22">Houweling AC</searchLink>; Department of Human Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ingles+J%22">Ingles J</searchLink>; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Genomics and Inherited Disease Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Ingrey+A%22">Ingrey A</searchLink>; Hunter Genetics, Hunter New England Local Health District, Newcastle, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Jabbour+A%22">Jabbour A</searchLink>; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Heart Transplantation Division, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia.; Cardiology Department, St Vincent's Hospital Sydney, 390 Victoria St, Darlinghurst, NSW 2010, Australia.<br /><searchLink fieldCode="AU" term="%22James+PA%22">James PA</searchLink>; Genomic Medicine, Royal Melbourne Hospital, Melbourne, VIC, Australia.; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Jansweijer+JA%22">Jansweijer JA</searchLink>; Department of Clinical and Experimental Cardiology, Amsterdam University Medical Centre, Amsterdam, The Netherlands.; Department of Cardiology, Haga Teaching Hospital, The Hague, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Jongbloed+JDH%22">Jongbloed JDH</searchLink>; Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Keogh+AM%22">Keogh AM</searchLink>; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Heart Transplantation Division, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia.; Cardiology Department, St Vincent's Hospital Sydney, 390 Victoria St, Darlinghurst, NSW 2010, Australia.<br /><searchLink fieldCode="AU" term="%22Larrañaga-Moreira+JM%22">Larrañaga-Moreira JM</searchLink>; Unidad de Cardiopatías Familiares, INIBIC, Complexo Hospitalario Universitario de A Coruña, Servizo Galego de Saúde, Universidade da Coruña, A Coruña, Spain.<br /><searchLink fieldCode="AU" term="%22Lekanne+Deprez+RH%22">Lekanne Deprez RH</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Human Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Macciocca+I%22">Macciocca I</searchLink>; Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Melbourne, VIC, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Macdonald+PS%22">Macdonald PS</searchLink>; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Heart Transplantation Division, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia.; Cardiology Department, St Vincent's Hospital Sydney, 390 Victoria St, Darlinghurst, NSW 2010, Australia.<br /><searchLink fieldCode="AU" term="%22Mansencal+N%22">Mansencal N</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Emergency Medicine, AP-HP, Hôpital Ambroise Paré, Boulogne-Billancourt, France.<br /><searchLink fieldCode="AU" term="%22Mansour+J%22">Mansour J</searchLink>; Tasmanian Clinical Genetics Service and Tasmanian Health Service, Hobart, TAS, Australia.<br /><searchLink fieldCode="AU" term="%22Martinez-Veira+C%22">Martinez-Veira C</searchLink>; Unidad de Cardiopatías Familiares, CIBERCV, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22McDonough+B%22">McDonough B</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22McGaughran+J%22">McGaughran J</searchLink>; Genetic Health Queensland Service, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.; School of Medicine, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Medo+K%22">Medo K</searchLink>; Cardiovascular Institute and Adult Medical Genetics Program, University of Colorado, Cardiovascular Institute, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Merlo+M%22">Merlo M</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiothoracovascular, Azienda Sanitaria Universitaria Integrata, Trieste, Italy.; Department of Medicine, University of Trieste, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Michalak+E%22">Michalak E</searchLink>; Unit for Screening Studies in Inherited Cardiovascular Diseases, National Institute of Cardiology, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Monserrat+L%22">Monserrat L</searchLink>; Department of Cardiology, Health in Code, A Coruña, Spain.<br /><searchLink fieldCode="AU" term="%22Mountain+H%22">Mountain H</searchLink>; Genetic Services of Western Australia, Perth, WA, Australia.; Genetic Counselling Department, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Muller+SA%22">Muller SA</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Murphy+AM%22">Murphy AM</searchLink>; Division of Pediatric Cardiology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Murray+B%22">Murray B</searchLink>; Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Oates+EC%22">Oates EC</searchLink>; School of Biotechnology and Biomolecular Sciences, Faculty of Science, UNSW Sydney, Sydney, NSW, Australia.; Department of Neurology, Sydney Children's Hospital, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Ormondroyd+E%22">Ormondroyd E</searchLink>; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Pachter+N%22">Pachter N</searchLink>; Genetic Services of Western Australia, Perth, WA, Australia.; Genetic Services Department, King Edward Memorial Hospital, Perth, WA, Australia.; School of Medicine, University of Western Australia, Perth, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Paldino+A%22">Paldino A</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiothoracovascular, Azienda Sanitaria Universitaria Integrata, Trieste, Italy.; Department of Medicine, University of Trieste, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Palmyre+A%22">Palmyre A</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Genetics and Referral Center for Hereditary Cardiac Diseases, AP-HP, Hôpital Ambroise Paré, Boulogne-Billancourt, France.<br /><searchLink fieldCode="AU" term="%22Pereira+NL%22">Pereira NL</searchLink>; Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Windland Smith Rice Genetic Heart Rhythm Clinic, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Picard+KC%22">Picard KC</searchLink>; Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Poplawski+N%22">Poplawski N</searchLink>; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.; Discipline of Paediatrics, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Prasad+S%22">Prasad S</searchLink>; National Heart and Lung Institute, Imperial College, London, UK.<br /><searchLink fieldCode="AU" term="%22Proukhnitzky+J%22">Proukhnitzky J</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Genetics and Cardiology Department, Sorbonne Université, AP-HP, INSERM UMRS_1166, IHU-ICAN, Hôpital Pitié-Salpêtrière, Paris, France.<br /><searchLink fieldCode="AU" term="%22Pruny+JF%22">Pruny JF</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Sorbonne Université, Centre de Référence pour les Maladies Cardiaques Héréditaires ou rares, AP-HP, INSERM UMRS_1166, IHU-ICAN, Hôpital Pitié-Salpêtrière, Paris, France.<br /><searchLink fieldCode="AU" term="%22Reant+P%22">Reant P</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Service de Cardiologie, Centre Hospitalier Universitaire de Bordeaux, Université de Bordeaux, CIC 1401, Bordeaux, France.; French Reference Center in Inherited Cardiomyopathies, ERN GUARD-Heart, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Richard+P%22">Richard P</searchLink>; Department of Cardiogenetic and Myogenetic Molecular and Cellular, Metabolic Biochemistry, AP-HP Sorbonne Université, Pitié Salpêtrière Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ronan+A%22">Ronan A</searchLink>; Genetics Unit, Newcastle Medical Genetics, Newcastle, NSW, Australia.; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Sedaghat-Hamedani+F%22">Sedaghat-Hamedani F</searchLink>; Department of Cardiology, Pneumology and Angiology, Heidelberg University Hospital, Heidelberg, Germany.; Informatics for Life, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Semsarian+C%22">Semsarian C</searchLink>; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Agnes Ginges Centre for Molecular Cardiology, Centenary Institute, University of Sydney, Sydney, NSW, Australia.; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Storm+G%22">Storm G</searchLink>; Cardiovascular Institute and Adult Medical Genetics Program, University of Colorado, Cardiovascular Institute, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Stroeks+S%22">Stroeks S</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands.; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Syrris+P%22">Syrris P</searchLink>; Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Taylor+MRG%22">Taylor MRG</searchLink>; Cardiovascular Institute and Adult Medical Genetics Program, University of Colorado, Cardiovascular Institute, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Thomson+K%22">Thomson K</searchLink>; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford Regional Genetics Laboratories, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Thompson+T%22">Thompson T</searchLink>; Genomic Medicine, Royal Melbourne Hospital, Melbourne, VIC, Australia.; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22van+Tintelen+JP%22">van Tintelen JP</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vissing+CR%22">Vissing CR</searchLink>; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Cardiology Department, Hvidovre Hospital, Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Waddell-Smith+KE%22">Waddell-Smith KE</searchLink>; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Wallis+M%22">Wallis M</searchLink>; Tasmanian Clinical Genetics Service and Tasmanian Health Service, Hobart, TAS, Australia.; School of Medicine and Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.<br /><searchLink fieldCode="AU" term="%22Zentner+D%22">Zentner D</searchLink>; Department of Cardiology, Royal Melbourne Hospital, Melbourne, VIC, Australia.; Genomic Medicine, Royal Melbourne Hospital, Melbourne, VIC, Australia.; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Arnott+C%22">Arnott C</searchLink>; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.; Cardiovascular Program, The George Institute for Global Health, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Marian+AJ%22">Marian AJ</searchLink>; Center for Cardiovascular Genetic Research, Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Oh+J%22">Oh J</searchLink>; Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Fokstuen+S%22">Fokstuen S</searchLink>; Department of Diagnostics, Service of Genetic Medicine, University Hospitals of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22James+CA%22">James CA</searchLink>; Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Barriales-Villa+R%22">Barriales-Villa R</searchLink>; Inherited Cardiovascular Disease Unit, Complexo Hospitalario Universitario A Coruña, A Coruña, Galicia, Spain.<br /><searchLink fieldCode="AU" term="%22Meder+B%22">Meder B</searchLink>; Department of Cardiology, Pneumology and Angiology, Heidelberg University Hospital, Heidelberg, Germany.; Informatics for Life, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wahbi+K%22">Wahbi K</searchLink>; Cardiology Department, AP-HP, Cochin Hospital, Paris, France.; Faculté de Médecine, Université Paris-Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Giudicessi+JR%22">Giudicessi JR</searchLink>; Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Windland Smith Rice Genetic Heart Rhythm Clinic, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Parikh+VN%22">Parikh VN</searchLink>; Department of Medicine, Stanford Center for Inherited Cardiovascular Disease, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ware+JS%22">Ware JS</searchLink>; Cardiology Department, Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.; Cardiovascular and Genomic Medicine, National Heart and Lung Institute and MRC London Institute of Medical Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Piriou+N%22">Piriou N</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Centre de Référence Cardiomyopathies, L'institut du Thorax, Nantes Université, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Rooryck+C%22">Rooryck C</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Service de Génétique Médicale, CHU Bordeaux, Bordeaux, France.; Maladies Rares: Génétique et Métabolisme, Université de Bordeaux, INSERMU1211, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Lakdawala+NK%22">Lakdawala NK</searchLink>; Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mestroni+L%22">Mestroni L</searchLink>; Cardiovascular Institute and Adult Medical Genetics Program, University of Colorado, Cardiovascular Institute, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Sinagra+G%22">Sinagra G</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiothoracovascular, Azienda Sanitaria Universitaria Integrata, Trieste, Italy.; Department of Medicine, University of Trieste, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Elliott+PM%22">Elliott PM</searchLink>; Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, London, UK.; Department of Inherited Cardiovascular Diseases, Barts Heart Centre, St Bartholomew's Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Watkins+H%22">Watkins H</searchLink>; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22McNally+EM%22">McNally EM</searchLink>; Center for Genetic Medicine, Northwestern University, Evanston, IL, USA.; Center for Genetic Medicine, Bluhm Cardiovascular Institute, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Charron+P%22">Charron P</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Genetics and Referral Center for Hereditary Cardiac Diseases, AP-HP, Hôpital Ambroise Paré, Boulogne-Billancourt, France.; Sorbonne Université, Centre de Référence pour les Maladies Cardiaques Héréditaires ou rares, AP-HP, INSERM UMRS_1166, IHU-ICAN, Hôpital Pitié-Salpêtrière, Paris, France.<br /><searchLink fieldCode="AU" term="%22van+Spaendonck-Zwarts+KY%22">van Spaendonck-Zwarts KY</searchLink>; Genetic Health Queensland Service, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.; Department of Human Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Garcia-Pavia+P%22">Garcia-Pavia P</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Hospital Universitario Puerta de Hierro, Instituto Investigación Sanitaria Puerta de Hierro-Segovia de Arana, CIBERCV, Madrid, Spain.; Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Peña-Peña+ML%22">Peña-Peña ML</searchLink>; Department of Cardiology, Virgen del Rocio University Hospital, Seville, Spain.<br /><searchLink fieldCode="AU" term="%22Mogensen+J%22">Mogensen J</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Christensen+AH%22">Christensen AH</searchLink>; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bilińska+ZT%22">Bilińska ZT</searchLink>; Unit for Screening Studies in Inherited Cardiovascular Diseases, National Institute of Cardiology, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Rasmussen+TB%22">Rasmussen TB</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Seidman+JG%22">Seidman JG</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Seidman+CE%22">Seidman CE</searchLink>; Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Te+Riele+ASJM%22">Te Riele ASJM</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Verdonschot+JAJ%22">Verdonschot JAJ</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands.; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Pinto+YM%22">Pinto YM</searchLink>; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands.; Department of Clinical Cardiology and Experimental Cardiology, University of Amsterdam, Amsterdam University Medical Centers, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Christiaans+I%22">Christiaans I</searchLink>; Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Fatkin+D%22">Fatkin D</searchLink>; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, 405 Liverpool St, Darlinghurst, NSW 2010, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Cardiology Department, St Vincent's Hospital Sydney, 390 Victoria St, Darlinghurst, NSW 2010, Australia.
– Name: AuthorCorporate
  Label: Corporate Authors
  Group: Au
  Data: <searchLink fieldCode="CA" term="%22Australian+Genomics+Cardiac+Flagship%22">Australian Genomics Cardiac Flagship</searchLink>
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  Data: <searchLink fieldCode="JN" term="%228006263%22">European heart journal</searchLink> [Eur Heart J] 2025 Dec 22; Vol. 46 (48), pp. 5240-5257.
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  Data: Journal Article; Multicenter Study; Observational Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8006263 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1522-9645 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220195668X%22">0195668X </searchLink><i>NLM ISO Abbreviation: </i>Eur Heart J <i>Subsets: </i>MEDLINE
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            – D: 22
              M: 12
              Text: 2025 Dec 22
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1522-9645
          Numbering:
            – Type: volume
              Value: 46
            – Type: issue
              Value: 48
          Titles:
            – TitleFull: European heart journal
              Type: main
ResultId 1