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Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age.

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Title: Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age.
Authors: Wells SB; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Rainbow DB; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Mark M; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., Szabo PA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Ergen C; Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, CA, USA., Caron DP; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Maceiras AR; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK., Rahmani E; Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, CA, USA., Benuck E; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., Valiollah Pour Amiri V; Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, CA, USA., Chen D; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Wagner A; Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, CA, USA., Howlett SK; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Jarvis LB; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Ellis KL; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Kubota M; Department of Surgery, Columbia University Irving Medical Center, New York, NY, USA., Matsumoto R; Department of Surgery, Columbia University Irving Medical Center, New York, NY, USA., Mahbubani K; Department of Surgery, University of Cambridge, Cambridge, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge, UK., Conde CD; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Richardson L; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Xu C; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK., Li S; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK., Mamanova L; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Bolt L; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Wilk A; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK., Teichmann SA; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK. sat1003@cam.ac.uk.; Department of Medicine, University of Cambridge, Cambridge, UK. sat1003@cam.ac.uk.; CIFAR Macmillan Multi-scale Human Programme, CIFAR, Toronto, Ontario, Canada. sat1003@cam.ac.uk., Farber DL; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA. df2396@cumc.columbia.edu.; Department of Surgery, Columbia University Irving Medical Center, New York, NY, USA. df2396@cumc.columbia.edu., Sims PA; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA. pas2182@cumc.columbia.edu.; Department of Biochemistry & Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA. pas2182@cumc.columbia.edu., Jones JL; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. jls53@medschl.cam.ac.uk., Yosef N; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel. nir.yosef@weizmann.ac.il.; Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, CA, USA. nir.yosef@weizmann.ac.il.
Source: Nature immunology [Nat Immunol] 2025 Sep; Vol. 26 (9), pp. 1612-1625. Date of Electronic Publication: 2025 Aug 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Wells+SB%22">Wells SB</searchLink>; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rainbow+DB%22">Rainbow DB</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Mark+M%22">Mark M</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Szabo+PA%22">Szabo PA</searchLink>; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ergen+C%22">Ergen C</searchLink>; Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Caron+DP%22">Caron DP</searchLink>; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Maceiras+AR%22">Maceiras AR</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Rahmani+E%22">Rahmani E</searchLink>; Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Benuck+E%22">Benuck E</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Valiollah+Pour+Amiri+V%22">Valiollah Pour Amiri V</searchLink>; Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; 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Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Mamanova+L%22">Mamanova L</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bolt+L%22">Bolt L</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wilk+A%22">Wilk A</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Teichmann+SA%22">Teichmann SA</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK. sat1003@cam.ac.uk.; Department of Medicine, University of Cambridge, Cambridge, UK. sat1003@cam.ac.uk.; CIFAR Macmillan Multi-scale Human Programme, CIFAR, Toronto, Ontario, Canada. sat1003@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Farber+DL%22">Farber DL</searchLink>; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA. df2396@cumc.columbia.edu.; Department of Surgery, Columbia University Irving Medical Center, New York, NY, USA. df2396@cumc.columbia.edu.<br /><searchLink fieldCode="AU" term="%22Sims+PA%22">Sims PA</searchLink>; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA. pas2182@cumc.columbia.edu.; Department of Biochemistry & Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA. pas2182@cumc.columbia.edu.<br /><searchLink fieldCode="AU" term="%22Jones+JL%22">Jones JL</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. jls53@medschl.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Yosef+N%22">Yosef N</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel. nir.yosef@weizmann.ac.il.; Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, CA, USA. nir.yosef@weizmann.ac.il.
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  Data: <searchLink fieldCode="JN" term="%22100941354%22">Nature immunology</searchLink> [Nat Immunol] 2025 Sep; Vol. 26 (9), pp. 1612-1625. <i>Date of Electronic Publication: </i>2025 Aug 13.
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