Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age.
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| Title: | Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age. |
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| Authors: | Wells SB; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Rainbow DB; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Mark M; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., Szabo PA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Ergen C; Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, CA, USA., Caron DP; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Maceiras AR; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK., Rahmani E; Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, CA, USA., Benuck E; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., Valiollah Pour Amiri V; Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, CA, USA., Chen D; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Wagner A; Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, CA, USA., Howlett SK; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Jarvis LB; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Ellis KL; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Kubota M; Department of Surgery, Columbia University Irving Medical Center, New York, NY, USA., Matsumoto R; Department of Surgery, Columbia University Irving Medical Center, New York, NY, USA., Mahbubani K; Department of Surgery, University of Cambridge, Cambridge, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge, UK., Conde CD; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Richardson L; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Xu C; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK., Li S; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK., Mamanova L; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Bolt L; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Wilk A; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK., Teichmann SA; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK. sat1003@cam.ac.uk.; Department of Medicine, University of Cambridge, Cambridge, UK. sat1003@cam.ac.uk.; CIFAR Macmillan Multi-scale Human Programme, CIFAR, Toronto, Ontario, Canada. sat1003@cam.ac.uk., Farber DL; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA. df2396@cumc.columbia.edu.; Department of Surgery, Columbia University Irving Medical Center, New York, NY, USA. df2396@cumc.columbia.edu., Sims PA; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA. pas2182@cumc.columbia.edu.; Department of Biochemistry & Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA. pas2182@cumc.columbia.edu., Jones JL; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. jls53@medschl.cam.ac.uk., Yosef N; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel. nir.yosef@weizmann.ac.il.; Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, CA, USA. nir.yosef@weizmann.ac.il. |
| Source: | Nature immunology [Nat Immunol] 2025 Sep; Vol. 26 (9), pp. 1612-1625. Date of Electronic Publication: 2025 Aug 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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