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Tecovirimat is active against various MPXV strains, while cidofovir, brincidofovir, trifluridine, and gemcitabine have no detectable MPXV-specific antiviral activity.

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Title: Tecovirimat is active against various MPXV strains, while cidofovir, brincidofovir, trifluridine, and gemcitabine have no detectable MPXV-specific antiviral activity.
Authors: Higashi-Kuwata N; Department of Refractory Viral Diseases, National Institute of Global Health and Medicine, Japan Institute for Health Security, Shinjuku-Ku, Tokyo 162-8655, Japan. Electronic address: kuwata.n@jihs.go.jp., Kato M; Department of Refractory Viral Diseases, National Institute of Global Health and Medicine, Japan Institute for Health Security, Shinjuku-Ku, Tokyo 162-8655, Japan., Hattori SI; Department of Refractory Viral Diseases, National Institute of Global Health and Medicine, Japan Institute for Health Security, Shinjuku-Ku, Tokyo 162-8655, Japan., Takamatsu Y; Department of Refractory Viral Diseases, National Institute of Global Health and Medicine, Japan Institute for Health Security, Shinjuku-Ku, Tokyo 162-8655, Japan., Mitsuya H; Department of Refractory Viral Diseases, National Institute of Global Health and Medicine, Japan Institute for Health Security, Shinjuku-Ku, Tokyo 162-8655, Japan; Kumamoto University Hospital, Kumamoto, 860-8556, Japan; Experimental Retrovirology Section, National Cancer Institute, NIH, Bethesda, MD, USA. Electronic address: hiroaki.mitsuya2@nih.gov.
Source: Virus research [Virus Res] 2025 Oct; Vol. 360, pp. 199615. Date of Electronic Publication: 2025 Aug 12.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8410979 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7492 (Electronic) Linking ISSN: 01681702 NLM ISO Abbreviation: Virus Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tecovirimat is active against various MPXV strains, while cidofovir, brincidofovir, trifluridine, and gemcitabine have no detectable MPXV-specific antiviral activity.
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  Data: <searchLink fieldCode="AU" term="%22Higashi-Kuwata+N%22">Higashi-Kuwata N</searchLink>; Department of Refractory Viral Diseases, National Institute of Global Health and Medicine, Japan Institute for Health Security, Shinjuku-Ku, Tokyo 162-8655, Japan. Electronic address: kuwata.n@jihs.go.jp.<br /><searchLink fieldCode="AU" term="%22Kato+M%22">Kato M</searchLink>; Department of Refractory Viral Diseases, National Institute of Global Health and Medicine, Japan Institute for Health Security, Shinjuku-Ku, Tokyo 162-8655, Japan.<br /><searchLink fieldCode="AU" term="%22Hattori+SI%22">Hattori SI</searchLink>; Department of Refractory Viral Diseases, National Institute of Global Health and Medicine, Japan Institute for Health Security, Shinjuku-Ku, Tokyo 162-8655, Japan.<br /><searchLink fieldCode="AU" term="%22Takamatsu+Y%22">Takamatsu Y</searchLink>; Department of Refractory Viral Diseases, National Institute of Global Health and Medicine, Japan Institute for Health Security, Shinjuku-Ku, Tokyo 162-8655, Japan.<br /><searchLink fieldCode="AU" term="%22Mitsuya+H%22">Mitsuya H</searchLink>; Department of Refractory Viral Diseases, National Institute of Global Health and Medicine, Japan Institute for Health Security, Shinjuku-Ku, Tokyo 162-8655, Japan; Kumamoto University Hospital, Kumamoto, 860-8556, Japan; Experimental Retrovirology Section, National Cancer Institute, NIH, Bethesda, MD, USA. Electronic address: hiroaki.mitsuya2@nih.gov.
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  Data: <searchLink fieldCode="JN" term="%228410979%22">Virus research</searchLink> [Virus Res] 2025 Oct; Vol. 360, pp. 199615. <i>Date of Electronic Publication: </i>2025 Aug 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8410979 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-7492 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201681702%22">01681702 </searchLink><i>NLM ISO Abbreviation: </i>Virus Res <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.virusres.2025.199615
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        Text: English
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        StartPage: 199615
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      – TitleFull: Tecovirimat is active against various MPXV strains, while cidofovir, brincidofovir, trifluridine, and gemcitabine have no detectable MPXV-specific antiviral activity.
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              Text: 2025 Oct
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